Some Chemical Aspects of 1,2,4-triazine derivatives

Abstract

Condensation of 3a,b with some aromatic aldehydes afforded the Schiff bases (4a-f). Reaction of 3a,b with aromatic aldehydes and alkyl phosphites gave the corresponding amino phosphonates (5a-d). Heating 3a,b with 6a-f in POCl3 at 85 °C furnished the amino sulphonamides (7a-l). Acid hydrolysis of compounds 7a,b and 7k) furnished the amines (8a-c). Condensation of 3a, b with 9a,b afforded the cyclized product (10a,b). Reaction of 3a with halo esters afforded 12 and 13. Heating 3a,b with 14a-c afforded 15a-f. Hydrolysis of 15a,b afforded 16a,b. Fusion of 3a,b with 1,4-butane sultone gave sultams (18a,b). The antimicrobial activity o9f some products was tried