Some critical points in the interaction between homogeneous non-ionic surfactants and poly(acrylic acid)

Anghel, Dan F.; Saito, Setsuo; Iovescu, Alina; Băran, Adriana

doi:10.1016/0927-7757(94)02891-5

Cited by 36 publications

(38 citation statements)

References 15 publications

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“…For PAA-nonionic surfactant systems, the T 1 determination by surface tension measurements was confirmed from fluorescence spectral change, with pyrene as probe [38,39]. However, this method was not successful for the PMA mixed systems because the polymer environment solubilizing the probe is semi-nonpolar [29].…”

Section: Surface Tensionmentioning

confidence: 98%

Counterion Effect of Cationic Surfactants Upon the Interaction with Poly(methacrylic acid)

Anghel¹,

Saito²,

Iovescu

et al. 2010

J Surfact & Detergents

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This work investigates decylammonium salts, with inorganic (chloride and thiocyanate) and organic (acetate and butyrate) counterions, in interaction with poly(methacrylic acid) (PMA). The study is conducted by means of surface tension, relative viscosity and pH measurements. The role of the methyl group in PMA appears by comparison with analogous mixtures of poly(acrylic acid) (PAA). In aqueous solution, a non-cooperative interaction between the surfactant and the hydrophobic microdomains (HMD) of PMA starts first. With surfactant addition, micellar aggregates bound onto the polymer chain appear at a concentration T 1 , which is higher than for the analogous PAA systems, but lower than the respective CMC. T 1 is lower for chloride than for thiocyanate and lower for acetate than for butyrate. Depending on the counterion, the HMD conceal or expose carboxyl groups, with influence upon the interaction strength and the bulk and surface behavior. Stronger interactions and maxima of surface tension and relative viscosity appear for the systems with organic counterions. An estimation of the interaction strength shows weaker surfactant interactions with PMA than with PAA, and that acetate induces the strongest interaction while thiocyanate the weakest.

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Section: Surface Tensionmentioning

confidence: 98%

Counterion Effect of Cationic Surfactants Upon the Interaction with Poly(methacrylic acid)

Anghel¹,

Saito²,

Iovescu

et al. 2010

J Surfact & Detergents

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“…The results put in evidence that C 8 E 5 interacts with low-molecular-weight PAA, leading to the formation of surfactant clusters bound to the polymer chain. However, as will be discussed in the following sections, a comparative analysis of the experimental evidence shows that the interaction behavior of this system is quite different with respect to that of systems containing polymers with higher molecular weight [11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 95%

“…The mixtures of nonionic surfactants and weakly dissociated polyelectrolytes, such as poly(acrylic acid), have been widely studied by Saito and his collaborators [11][12][13][14] and by other researchers [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Interaction between pentaethylene glycol n-octyl ether and low-molecular-weight poly(acrylic acid)

D’Errico¹,

Ciccarelli²,

Ortona³

et al. 2004

Journal of Colloid and Interface Science

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“…The association of poly(acrylic acid)s with ethoxylated surfactants is extraordinarily intense [3,15,16]. In previous work [40], we observed using IR spectroscopy and differential scanning calorimetry of films, that carbopol interaction with Pluronic F-127 and Tween 80 in water depends markedly on their weight ratio and that, in fact, hydrogen bonding occurs between the carbopol carboxylic groups and the oxygen of the ethylene oxide chains of the surfactants.…”

Section: Carbopol-nonionic Surfactant Aggregationmentioning

confidence: 96%

“…Polymers and surfactants are commonly formulated together to improve the solubility and bioavailability of the drug, or the stability and rheological properties of the dosage form itself [3,14]. Although the information regarding the interactions of linear poly(acrylic acid)s with nonionic [15,16,17] and ionic [18,19,20,21] surfactants is extensive, much less attention has been paid to cross-linked networks [10,12,22,23]. In addition, most studies were carried out in pure water and may not reflect the microgel-surfactant interactions in the presence of ions under physiological conditions.…”

mentioning

confidence: 99%

Microcalorimetric evidence and rheological consequences of the salt effect on carbopol-surfactant interactions

Barreiro-Iglesias

Álvarez-Lorenzo

Aqueous Polymer — Cosolute Systems

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IntroductionSlightly cross-linked polymer networks that can absorb a large amount of solvent and can undergo sharp conformational transitions in response to changes in temperature, pH or chemical composition of the medium find a wide range of applications [1]. Smart microgel systems are particularly useful as platforms for gelling in situ drug dosage forms, which are easily administered (ocularly, orally, parenterally) in the liquid state [2,3,4,5]. In contact with the physiological environment, the viscosity and elasticity of the system rise strongly, increasing the residence time on the application area and allowing optimum control of the drug release process. Carbopol microgels, constituted by poly(acrylic acid) cross-linked with allylsucrose, are the most Progr Colloid Polym Sci (2003) Abstract The aggregation process of Carbopol 934NF, a Food and Drug Administration approved cross-linked poly(acrylic acid) commonly used in pharmaceutical technology, with nonionic and ionic surfactants in 0.9% NaCl dispersions and artificial lacrimal fluid was analyzed using titration microcalorimetry and rheometry. Titration microcalorimetry experiments indicated that the interaction processes in 0.9% NaCl are thermodynamically similar to those in water, although slightly less intense. In contrast, in artificial lacrimal fluid the carbopol-surfactant interactions were hindered. Carbopol association with Tween 80 (exothermic) or Pluronic F-127 (endothermic) occurs through hydrogen-bonding interactions, which are scarcely debilitated in 0.9% NaCl but strongly impeded in artificial lacrimal fluid. In this medium, the higher pH causes more carboxylic acid groups to become ionized, and the presence of calcium ions blocks them partially. In 0.9% NaCl, there is a shielding effect of the ionic groups of the polymer that promotes the hydrophobic association with sodium dodecyl sulfate and makes the complex formation with benzalkonium chloride more difficult. In both cases, the processes were exothermic. In artificial lacrimal fluid, the interaction with sodium dodecyl sulfate disappears while an endothermic association with benzalkonium chloride takes place. The ion-induced changes in the intensity of the carbopol-surfactant association are reflected in the rheological behavior of the 0.25% acrylic polymer dispersions. The results show that the nature and concentration of ions may have a strong influence on the design and on the physiological behavior of drug delivery systems based on carbopol gels.

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Some critical points in the interaction between homogeneous non-ionic surfactants and poly(acrylic acid)

Cited by 36 publications

References 15 publications

Counterion Effect of Cationic Surfactants Upon the Interaction with Poly(methacrylic acid)

Counterion Effect of Cationic Surfactants Upon the Interaction with Poly(methacrylic acid)

Interaction between pentaethylene glycol n-octyl ether and low-molecular-weight poly(acrylic acid)

Microcalorimetric evidence and rheological consequences of the salt effect on carbopol-surfactant interactions

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