Some Current Concepts of the Chemical Nature of Antigens and Antibodies

Campbell, Dan H.; Bulman, Norman

doi:10.1007/978-3-7091-7169-1_10

Cited by 2 publications

(1 citation statement)

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“…Although the antibody combining site was thought to occupy only 1% of the surface of immunoglobulins [1], this axiom made it hard for many research workers during the 1960' to believe that a microbial structure could react with antibodies ir-respective of the specificity of the Fab part. We now know that substances which interact with the Fc part of IgG are widespread among microorganisms.…”

Section: Introductionmentioning

confidence: 99%

Possible role of microbial IgG Fc-binding proteins in rheumatoid arthritis

Christensen

Schröder

1990

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IgG Fc binding substances (receptors) are widespread among pathogenic microorganisms. The receptors from Staphylococcus aureus, streptococci of group A, C and G as well as Herpes-infected cells bind to the interface between the CH2 and CH3 domains i.e. to His 435, Tyr 436 and possibly also His 433 and/or 310. Most rheumatoid factors (RF) from patients with rheumatoid arthritis show a similar binding pattern. Hence, it has been shown that antibodies to microbial IgG Fc receptors (S. aureus and group A streptococci type M15) and RF are idiotypic-anti-idiotypic antibody "partners" i.e. that RF are the "internal images" of microbial IgG Fc binding proteins. Group A streptococci possessing IgG Fc receptors elicit higher titres of RF when injected in rabbits as compared to group A streptococci without IgG Fc receptors. The streptococcal IgG Fc receptors exhibit a diversity of preferences for subclasses of human IgG, some of them showing allotype preferences. Such allotypes are also recognized by certain RF. IgG RF are able to self-associate thereby forming immune complexes which can activate the complement cascade as well as stimulate release of prostaglandins and (probably) interleukin-1. Since these factors have been assigned an important pathogenic role in rheumatoid arthritis, self-aggregating IgG RF, proposed to be induced by microbial IgG Fc receptors might be an important pathogenic factor in rheumatoid arthritis because rheumatoid arthritis is the only known condition where synthesis of RF takes place in the synovia.

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Section: Introductionmentioning

confidence: 99%