Some Effects of a Topical Collagen-Based Matrix on the Microcirculation and Wound Healing in Patients With Chronic Venous Leg Ulcers: Preliminary Observations

Wollina, Uwe; Schmidt, W.; Krönert, Claudia; Nelskamp, Cornelia; Scheibe, Armin; Faßler, D.

doi:10.1177/1534734605283001

Cited by 37 publications

(22 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This has limited the utility of testing chronic wounds for excessive proteases in clinical practice despite the acknowledged potential that such diagnostic tests might have in selecting treatment plans . For example, a nonhealing wound with EPA could be treated with protease‐modulating agents such as doxycycline, or collagen/oxidized regenerated cellulose dressings …”

Section: Discussionmentioning

confidence: 99%

Defining a new diagnostic assessment parameter for wound care: Elevated protease activity, an indicator of nonhealing, for targeted protease‐modulating treatment

Serena

Cullen²,

Bayliff

et al. 2016

Wound Repair Regeneration

View full text Add to dashboard Cite

It is widely accepted that elevated protease activity (EPA) in chronic wounds impedes healing. However, little progress has occurred in quantifying the level of protease activity that is detrimental for healing. The aim of this study was to determine the relationship between inflammatory protease activity and wound healing status, and to establish the level of EPA above which human neutrophil-derived elastase (HNE) and matrix metalloproteases (MMP) activities correlate with nonhealing wounds. Chronic wound swab samples (n = 290) were collected from four wound centers across the USA to measure HNE and MMP activity. Healing status was determined according to percentage reduction in wound area over the previous 2-4 weeks; this was available for 211 wounds. Association between protease activity and nonhealing wounds was determined by receiver operating characteristic analysis (ROC), a statistical technique used for visualizing and analyzing the performance of diagnostic tests. ROC analysis showed that area under the curve (AUC) for HNE were 0.69 for all wounds and 0.78 for wounds with the most reliable wound trajectory information, respectively. For MMP, the corresponding AUC values were 0.70 and 0.82. Analysis suggested that chronic wounds having values of HNE >5 and/or MMP ≥13, should be considered wound healing impaired. EPA is indicative of nonhealing wounds. Use of a diagnostic test to detect EPA in clinical practice could enable clinicians to identify wounds that are nonhealing, thus enabling targeted treatment with protease modulating therapies.

show abstract

Section: Discussionmentioning

confidence: 99%

Defining a new diagnostic assessment parameter for wound care: Elevated protease activity, an indicator of nonhealing, for targeted protease‐modulating treatment

Serena

Cullen²,

Bayliff

et al. 2016

Wound Repair Regeneration

View full text Add to dashboard Cite

show abstract

“…33 In this study, 37% of ulcers healed within 12 weeks of ORC/collagen treatment compared with 28% treated with moist gauze control (there was not a significant difference, as P = .12). In a case-cohort observational study for the treatment of venous ulcers, ORC significantly improved ulcer area compared with polyurethane or hydrocolloid dressings (P G .05), 34 although the study design is not as rigorous as a randomized trial. A modified ORC product that contains 55% collagen, 44% ORC, and 1% silver-ORC (Prisma; Ethicon, Inc, a Johnson & Johnson Company, Somerville, NJ) has not been evaluated in clinical trials, but it is sometimes advocated as a substitute for ORC in infected wounds.…”

Section: Discussionmentioning

confidence: 99%

Bioactivity of Small Intestinal Submucosa and Oxidized Regenerated Cellulose/Collagen

Nihsen

Johnson²,

Hiles³

2008

Advances in Skin &Amp; Wound Care

View full text Add to dashboard Cite

show abstract

“…Leg ulcers are associated with disabling pain and chronicity (36), have a major impact on quality of life (37) and for patients with previously unsuccessful wound treatment, the condition can persist for years. ECM treatment of hard-toheal wounds has been associated with greater pain reduction compared to control treatments (35,(38)(39)(40)(41), albeit that the instruments for measuring pain greatly vary. Nevertheless, the important pain reduction following treatment with the synthetic ECM protein compares favourably with that published for an animal-derived protein, amelogenin (Xelma ® , Mölnlycke, Sweden) in a reported 12 week study where pain reduction was significantly greater in the amelogenin treatment group compared to the control group (35,40).…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of an acellular synthetic matrix in the treatment of hard‐to‐heal leg ulcers

Harding

Aldons

Edwards

et al. 2013

International Wound Journal

View full text Add to dashboard Cite

Hard-to-heal leg ulcers are a major cause of morbidity in the elderly population. Despite improvements in wound care, some wounds will not heal and they present a significant challenge for patients and health care providers. A multi-centre cohort study was conducted to evaluate the effectiveness and safety of a synthetic, extracellular matrix protein as an adjunct to standard care in the treatment of hard-to-heal venous or mixed leg ulcers. Primary effectiveness criteria were (i) reduction in wound size evaluated by percentage change in wound area and (ii) healing assessed by number of patients healed by end of the 12 week study. Pain reduction was assessed as a secondary effectiveness criteria using VAS. A total of 45 patients completed the study and no difference was observed between cohorts for treatment frequency. Healing was achieved in 35·6% and wound size decreased in 93·3% of patients. Median wound area percentage reduction was 70·8%. Over 50% of patients reported pain on first visit and 87·0% of these reported no pain at the end of the study. Median time to first reporting of no pain was 14 days after treatment initiation. The authors consider the extracellular synthetic matrix protein an effective and safe adjunct to standard care in the treatment of hard-to-heal leg ulcers.

show abstract

Some Effects of a Topical Collagen-Based Matrix on the Microcirculation and Wound Healing in Patients With Chronic Venous Leg Ulcers: Preliminary Observations

Cited by 37 publications

References 35 publications

Defining a new diagnostic assessment parameter for wound care: Elevated protease activity, an indicator of nonhealing, for targeted protease‐modulating treatment

Defining a new diagnostic assessment parameter for wound care: Elevated protease activity, an indicator of nonhealing, for targeted protease‐modulating treatment

Bioactivity of Small Intestinal Submucosa and Oxidized Regenerated Cellulose/Collagen

Effectiveness of an acellular synthetic matrix in the treatment of hard‐to‐heal leg ulcers

Contact Info

Product

Resources

About