Some Effects of Non‐Surgical Therapy on Gingival Inflammatory Cell Subsets in Patients With Adult and Early‐Onset Periodontitis

Kleinfelder, Jörg W.; Lange, Dieter; Böcker, W.

doi:10.1902/jop.2000.71.10.1561

Cited by 9 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With respect to T lymphocyte density in chronic gingivitis, the present results do not agree with the literature, as most studies implicate T lymphocyte as the main cell type found in the inflammatory infiltrate during the initial stages of gingivitis (8,9). A labeling intensity score of 1 for CD4+ cells was exclusively observed in CP specimens, corroborating the studies of Kleinfelder et al (10). The fact that this experiment was restricted to the investigation of CD4+ T lymphocytes also seems to explain the reduced density of positive T cells observed in this sample because, even in small numbers, CD8+ T lymphocytes are also present in CP, as reported by Séguier et al (11).…”

Section: Discussioncontrasting

confidence: 77%

Immunohistochemical evaluation of the inflammatory response in periodontal disease

et al. 2008

View full text Add to dashboard Cite

In order to contribute to the knowledge of the pathogenesis of periodontal disease, an immunohistochemical analysis of the density of inflammatory mononucleated cells and the number of dendritic cells was performed using anti-CD4, anti-CD20, anti-CD25, anti-CD68 and anti-protein S-100 antibodies in 17 cases of chronic gingivitis (CG) and 25 of chronic periodontitis (CP). The CD4+ and CD68+ cells exhibited a diffuse distribution in the connective tissue. CD20+ cell distribution was predominantly in groups and the CD25+ cells exhibited a diffuse or focal distribution. The S-100+ cells were identified in the epithelium and the lamina propria, exhibiting distinct morphology and number. The statistical analysis showed no significant differences (p>0.05) between CG and CP regarding the density of the CD4+ and CD20+ cells and the number of S-100+ cells. However, significant differences (p<0.05) were found between the groups in the density of CD25+ and CD68+ cells . The density of macrophages was greater in CG and the level of cellular activation of the lymphocyte infiltrate was greater in CP. No differences were detected between the aforementioned conditions regarding the density of the T and B lymphocytes and to the number of the dendritic cells.

show abstract

Section: Discussioncontrasting

confidence: 77%

Immunohistochemical evaluation of the inflammatory response in periodontal disease

et al. 2008

View full text Add to dashboard Cite

show abstract

“…This clinical procedure might have contributed to decreased gingival inflammation and hence to an underestimation of APRIL and BLyS expression, although this is not certain. In this regard, it has been reported that scaling and root planing does not significantly affect the inflammatory infiltrate (B cells, plasma cells, and memory T cells) associated with chronic periodontitis (51). …”

Section: Discussionmentioning

confidence: 99%

The B Cell–Stimulatory Cytokines BLyS and APRIL Are Elevated in Human Periodontitis and Are Required for B Cell–Dependent Bone Loss in Experimental Murine Periodontitis

Abe

AlSarhan

Benakanakere

et al. 2015

The Journal of Immunology

View full text Add to dashboard Cite

B-lineage cells (B lymphocytes and plasma cells) predominate in the inflammatory infiltrate of human chronic periodontitis. However, their role in disease pathogenesis and the factors responsible for their persistence in chronic lesions are poorly understood. In this regard, two cytokines of the TNF ligand superfamily, namely a proliferation-inducing ligand (APRIL) and B-lymphocyte stimulator (BLyS), are important for the survival, proliferation, and maturation of B cells. We thus hypothesized that APRIL and/or BLyS are upregulated in periodontitis and contribute to induction of periodontal bone loss. This hypothesis was addressed in both human and mouse experimental systems. We show that, relative to healthy controls, the expression of APRIL and BLyS mRNA and protein was upregulated in natural and experimental periodontitis in humans and mice, respectively. The elevated expression of these cytokines correlated with increased numbers of B cells/plasma cells in both species. Moreover, APRIL and BLyS partially colocalized with kappa light chain-expressing B lineage cells at the epithelial-connective tissue interface. Ligature-induced periodontitis resulted in significantly less bone loss in B cell-deficient mice compared to wild-type controls. Ab-mediated neutralization of APRIL or BLyS diminished the number of B cells in the gingival tissue and inhibited bone loss in wild-type but not in B cell-deficient mice. In conclusion, B cells and specific cytokines involved in their growth and differentiation contribute to periodontal bone loss. Moreover, APRIL and BLyS have been identified as potential therapeutic targets in periodontitis.

show abstract

“…Successful periodontal therapy results clinically in shallow PDs and a low tendency towards BOP and microbiologically, in a low detection level of periodontal pathogens (Haffajee et al 1997). In addition, it reduces the size of the inflamed lesion and causes a decrease in the periodontal tissues of inflammatory cell subsets, like B cells, T cells and plasma cells (Jully et al 1986, Berglundh et al 1999, Kleinfelder et al 2000). As in the present study, these clinical and microbiological outcomes of the therapy have been accomplished, it may be suggested that the number of inflammatory cells in the lesions also decreased.…”

Section: Discussionmentioning

confidence: 99%

Increased release of IL‐12p70 by monocytes after periodontal therapy

Fokkema

Loos

Slegte

et al. 2003

J Clinic Periodontology

View full text Add to dashboard Cite

show abstract

Some Effects of Non‐Surgical Therapy on Gingival Inflammatory Cell Subsets in Patients With Adult and Early‐Onset Periodontitis

Cited by 9 publications

References 25 publications

Immunohistochemical evaluation of the inflammatory response in periodontal disease

Immunohistochemical evaluation of the inflammatory response in periodontal disease

The B Cell–Stimulatory Cytokines BLyS and APRIL Are Elevated in Human Periodontitis and Are Required for B Cell–Dependent Bone Loss in Experimental Murine Periodontitis

Increased release of IL‐12p70 by monocytes after periodontal therapy

Contact Info

Product

Resources

About