Some Experimental Models for the Study of Inflammation and Anti-Inflammatory Drugs

Rj, Gryglewski

doi:10.1007/978-3-0348-7290-4_2

Cited by 5 publications

(6 citation statements)

References 14 publications

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“…In this study we orally administered glucosamine to rats and evaluated its effect on adjuvant arthritis, a well-known model of rheumatoid arthritis, which is frequently used to assess the anti-inflammatory properties of drugs [16,18]. In the past, the effects of glucosamine on rat adjuvant arthritis were examined macroscopically, and glucosamine was reported to suppress the arthritis; e. g., the incidence of arthritis (i. e. the percentage of animals with nodules), the volume of hind paws, and the body weight-change [22].…”

Section: Discussionmentioning

confidence: 99%

“…In the time-course of rat adjuvant arthritis, two phases are distinguished: 1) the local inflammation (acute phase) reaching a peak 4 -5 days after adjuvant injection and characterized by the swelling of the injected paw, and 2) the systemic disease (chronic phase) starting 7 -14 days after adjuvant injection and the chronic arthritis propagates to the other paws [16,18]. Glucosamine significantly suppressed the increase in the swelling of both adjuvant-injected and -uninjected hind paws in chronic phase (from day 18 to day 22) (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Adjuvant arthritis was induced in 8 week-old rats by a single intradermal injection of 0.1 ml Freund's complete adjuvant (FCA) containing 0.6 mg heat-killed M. tuberculosis H37Ra emulsified in liquid paraffin (Wako Pure Chemical Industries, Osaka, Japan) into the footpad of the right hind paw [18,19]. Swelling of hind paws was monitored by using a plethysmometer (MK-101P, Muromachi Kikai Co., Ltd., Tokyo, Japan) before (day 0), and 4, 10, 14, 18 and 22 days after the FCA injection.…”

Section: Induction Of Adjuvant Arthritismentioning

confidence: 99%

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Preventive actions of a high dose of glucosamine on adjuvant arthritis in rats

Hua

Suguro

Hirano³

et al. 2005

Inflamm. res.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Induction Of Adjuvant Arthritismentioning

confidence: 99%

See 1 more Smart Citation

Preventive actions of a high dose of glucosamine on adjuvant arthritis in rats

Hua

Suguro

Hirano³

et al. 2005

Inflamm. res.

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“…20,21) In addition, it is well known that NSAIDs suppress the acute and chronic phases in inflammation, 22) while DMARDs selectively suppress the chronic At the end of the experiment (day 22), blood samples were taken from each rat through cardiac puncture with sodium heparin. The blood was centrifuged, and then the supernatant was stored as blood plasma.…”

Section: Discussionmentioning

confidence: 99%

Effects of a Casein Hydrolysate Prepared fromAspergillus oryzaeProtease on Adjuvant Arthritis in Rats

Hatori¹,

Ohki²,

Hirano³

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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“…Adjuvant arthritis was induced in 8-week-old rats by a single intradermal injection of 0.1 ml FCA containing 0.5 mg heat-killed M. tuberculosis H37Ra emulsified in liquid paraffin (Wako Pure Chemical Industries, Osaka, Japan) into the footpad of the right hind paw (20,21). …”

Section: Methodsmentioning

confidence: 99%

Evaluation of the effect of methionine and glucosamine on adjuvant arthritis in rats

Yamagishi¹,

Igarashi

Suzuki³

et al. 2012

Experimental and Therapeutic Medicine

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In the present study, we evaluated the effects of individual administration of methionine or glucosamine (GlcN) and compared with the combined administration of methionine and GlcN on the adjuvant arthritis model of rheumatoid arthritis in rats. Adjuvant arthritis was induced in female Lewis rats by injecting Freund’s complete adjuvant (FCA) into the right hind paws, and methionine (200 mg/kg body weight/day) and/or GlcN (400 mg/kg/day) were orally administered for 21 days. The progression of the adjuvant arthritis was clinically evaluated for characteristic signs and symptoms by employing an arthritis score. The administration of methionine combined with GlcN suppressed the swelling of FCA-uninjected left hind paws and the arthritis score. Additionally, histopathological examination revealed that the combined administration of methionine and GlcN markedly suppressed synovial hyperplasia and the destruction of the cartilage surface and articular meniscus of the knee joints of FCA-injected right hind paws. Furthermore, combined methionine and GlcN administration suppressed the increase in the levels of nitric oxide, prostaglandin E2 and hyaluronic acid in the plasma of rats with adjuvant arthritis. By contrast, individual administration of methionine or GlcN suppressed arthritis only slightly. These observations suggest that the combined administration of methionine and GlcN is more effective compared with individual administrations of methionine or GlcN in suppressing the progression of adjuvant arthritis (identified as swelling of joints and arthritis score), possibly by synergistically inhibiting synovial inflammation (identified as synovial hyperplasia and the destruction of the cartilage surface and articular meniscus) and the production of inflammatory mediators.

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Some Experimental Models for the Study of Inflammation and Anti-Inflammatory Drugs

Cited by 5 publications

References 14 publications

Preventive actions of a high dose of glucosamine on adjuvant arthritis in rats

Preventive actions of a high dose of glucosamine on adjuvant arthritis in rats

Effects of a Casein Hydrolysate Prepared fromAspergillus oryzaeProtease on Adjuvant Arthritis in Rats

Evaluation of the effect of methionine and glucosamine on adjuvant arthritis in rats

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