Water quality has long been an important part of the operation of nuclear power plants. Water is used as a working and cooling fluid in power plants. The quality of source waters to be used in the power plants after treatment should conform to the prescribed values of Physicochemical properties like pH, EC, TDS, alkalinity, hardness, presence of chloride content, silica, and heavy metals as recommended by technical guidelines. The Physicochemical properties of water must be recovered the recommended values of the World Health Organization (WHO), United States of Public Health (USPH), and power plant water chemistry guidelines. But the values of raw water are very far from the recommended values of Nuclear Power Plants operation. So, it needs to treat to use in the boilers. Gravitation, Carbon filtration, Ion exchange method, and Reverse Osmosis (RO) are good ways to treat the water before use in power plants. The aim of this chapter is to explore the water chemistry of the source water quality parameters values and those of the recommended values of technical guidelines.