Some Measurements on the Slowing Down of π Mesons in Tissue-equivalent Material

Sullivan, A.H.; Baarli, J.

doi:10.1088/0031-9155/13/3/310

Cited by 11 publications

(7 citation statements)

References 3 publications

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“…Particle track analysis from emulsion [1] and bubble chamber [2] experiments in antiproton beams have been interpreted to imply that a relatively large amount of energy could be dissipated by way of charged fragments of the nucleus on which the annihilation occurred. This local energy deposition has been estimated to be in the range 100-200 MeV [3], which can be compared with the 20 MeV or so left behind in a negative pion annihilation [4]. Hence there has been some speculation on the possibility of the use of antiproton beams as a therapeutic radiation in the future.…”

Section: Introductionmentioning

confidence: 99%

A measurement of the local energy deposition by antiprotons coming to rest in tissue-like material

Sullivan

1985

Phys. Med. Biol.

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A B S T R A C TThe measurement of the energy deposited in tissue-like plastic as a beam of low-energy antiprotons slows down is described. The resulting depth-dose curve is presented and compared to that of protons measured under similar conditions. The size of the stopping peak relative to the dose in the plateau is about twice that for protons which indicates that relatively small amounts of energy are deposited locally in an antiproton annihilation. Analysis of the data shows that out of the 2000 MeV available in an antiproton annihilation, on average less than 33 MeV is deposited close to the site of the interaction. This leads to the conclusion that antiprotons are unlikely to offer any marked advantage over other radiations for radiotherapeutic applications of the future.

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Section: Introductionmentioning

confidence: 99%

A measurement of the local energy deposition by antiprotons coming to rest in tissue-like material

Sullivan

1985

Phys. Med. Biol.

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“…The shape of the beam, assumed parallel, and the relative intensity of particles over its cross section are shown in figure 2 . The absorbed dose from beam contamination (muons and electrons) is, in practice, only -10 per cent of the total dose in the peak region (Sullivan et al 1968) . (1972) .…”

Section: Mathematical Formulationmentioning

confidence: 99%

“…values were established experimentally byTodd (1967) for cell survival after exposure to various types of ions having LET values over the range shown . for 50, 10 and 1 per cent survival of T-1 human kidney cells .…”

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confidence: 99%

Estimations of the R.B.E. for π⁻and π⁺from Survival Data of T-1 Human Kidney Cells

Dutrannois

Wright

Turner

et al. 1973

International Journal of Radiation Biology and Related Studies

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A Monte Carlo programme has been written for computing depth-dose distributions in water phantoms irradiated by positive and negative pion beams . Contributions to the dose from the primary pions and various secondary particles are tabulated . Their contributions have been weighted by a set of r .b .e . values obtained from biological experiments . In particular, estimates of the average r .b .e . for survival of T-1 human kidney cells (at approximately the 10 per cent level) have been carried out as functions of depth along the centre line for typical 7r -and Tr+ beams . Isodose curves are plotted for v beam. Examples of the variations in average r .b .e . with changes in the mean momentum and momentum spread of the beam are also calculated . Comparisons are made with some observed effects produced by pions on biological systems . R .B . 2 G Int J Radiat Biol Downloaded from informahealthcare.com by Osaka University on 12/01/14 For personal use only. Int J Radiat Biol Downloaded from informahealthcare.com by Osaka University on 12/01/14 For personal use only. Int J Radiat Biol Downloaded from informahealthcare.com by Osaka University on 12/01/14 For personal use only. Int J Radiat Biol Downloaded from informahealthcare.com by Osaka University on 12/01/14For personal use only.

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“…The depth-dose distribution for a pure pion beam was previously estimated by subtracting the dose contribution due to contaminants (Richman et d . 1966, Sullivan and Baarli 1968). The peak-to-plateau ratio and the width of the peak of a pion beam are very sensitive functions of its energy and energy spread and of the detector dimensions relative to the beam size ; hence, it is difficult to make a strict comparison of the present results with those previously published.…”

Section: Dose and Number Of Particles As A Function Of Depth In Watermentioning

confidence: 99%

“…Bcet'o and Richman 1965 Raju, Amer, Gnanapurani and Richman 1970). Some physical measurements were also made at CERN, Switzerland, and at Brookhaven National Laboratory (Fowler and Mayes 1967, Goebel 1966, Baarli 1967, Sullivan and Baarli 1968, Tisljar-Lentulis 1966.…”

Section: Introductionmentioning

confidence: 99%

Dosimetry of π^--mesons using silicon detectors and plastic scintillators

Raju¹,

Lampo²,

Curtis³

et al. 1971

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The dosimetry of both x+ and x--beams, by use of semiconductor detectors and plastic scintillators, is described. Depth-dose distributions, isodose distributions and integral and differential range curves are present'ed. By use of a time-of-flight system, the dosimetric information for a pure pion beam is obtained. The muon and electron contamination reduce the peak-to-plateau rat'io. Pion beams of low energy give better depth-dose distributions. Nearly 507; of the dose a t the peak of the depth-dose dist'ribution of a x--beam is found to be due to nuclear events. Depth-dose distributions measured by semiconductor detector and tissue-equivalent ionization chamber, are in close agreement with each other.* Machines that will produce pion intensities nearly two or three orders of magnitude higher than the one presently available are under construction at Los Alamos Scientific Laboratory ; Vancouver, Canada ; and Zurich, Switzerland.

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Some Measurements on the Slowing Down of π Mesons in Tissue-equivalent Material

Cited by 11 publications

References 3 publications

A measurement of the local energy deposition by antiprotons coming to rest in tissue-like material

A measurement of the local energy deposition by antiprotons coming to rest in tissue-like material

Estimations of the R.B.E. for π⁻and π⁺from Survival Data of T-1 Human Kidney Cells

Dosimetry of π^--mesons using silicon detectors and plastic scintillators

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Some Measurements on the Slowing Down of π Mesons in Tissue-equivalent Material

Cited by 11 publications

References 3 publications

A measurement of the local energy deposition by antiprotons coming to rest in tissue-like material

A measurement of the local energy deposition by antiprotons coming to rest in tissue-like material

Estimations of the R.B.E. for π−and π+from Survival Data of T-1 Human Kidney Cells

Dosimetry of π--mesons using silicon detectors and plastic scintillators

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Estimations of the R.B.E. for π⁻and π⁺from Survival Data of T-1 Human Kidney Cells

Dosimetry of π^--mesons using silicon detectors and plastic scintillators