Some Morphological Findings on the Heart of Adult Wistar Rats Following Experimental Artesunate Administration

Ajibade, A. J.; Fakunle, P.B.; Adewusi, MO; Oyewo, O.O.

doi:10.3923/crcpaj.2012.1.9

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…A reduction in the heart/body weight ratio in rats administered ciprofloxacin was also reported by Obaleye et al [52]. However, cardiac weight was reported to increase following the administration of artesunate, a monotherapy for malaria [53]. The observed reduction in the weight of the heart in this study may be as a result of interaction by the two drugs and possible generation of free radicals.…”

Section: Discussionsupporting

confidence: 84%

“…The observed reduction in the weight of the heart in this study may be as a result of interaction by the two drugs and possible generation of free radicals. Metabolism of drugs are known to generate free radicals and the abundance of free radicals leads to oxidative stress which may cause death of cardiac muscles [53]. The reduction in heart weight coupled with increase concentration of troponin in this study suggest that concomitant administration of artemether-lumefantrine and ciprofloxacin may be cardiotoxic.…”

Section: Discussionmentioning

confidence: 64%

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Assessing the effect of concomitant administration of artemether-lumefantrine and ciprofloxacin on some cardiac parameters in Wistar rats: “The remedial role of vitamin E”

Ndem¹,

Sylvanus²,

Bassey³

et al. 2021

GSC Biol. and Pharm. Sci.

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The effect of Vitamin E on some cardiac parameters following concomitant administration of artemether-lumefantrine (AL) and ciprofloxacin in male Wistar rats was investigated. Thirty-five male Wistar rats weighing between 190 – 220 g, used for the study were randomly divided into seven groups of five animals each. Group I served as the control. Group II - VII were administered; 8 mg/kg body weight (bw) of AL; 7.14 mg/kg bw of Ciprofloxacin; 8 mg/kg bw of AL + 7.14 mg/kg bw of Ciprofloxacin; 8 mg/kg bw of AL + 8.57 IU of Vitamin E; 7.14 mg/kg bw of Ciprofloxacin + 8.57 IU of Vitamin E; and 8 mg/kg bw of AL + 7.14 mg/kg bw of Ciprofloxacin + 8.57 IU of Vitamin E respectively. All the drugs were administered at their therapeutic regimen. Some cardiac parameters investigated include lipid profile, Troponin I, Troponin T, Creatine kinase, Lactate dehydrogenase and aspartate aminotransferase. The result showed significant (p < 0.05) increase in all the parameters of cardiac function when treatment groups were compared with control. The observed increase in cardiac indices were however significantly (p < 0.05) ameliorated in Groups V, VII and VII which were co-administered with Vitamin E compared with Groups II, III and IV which received the test drugs independently. The weights of the heart tissues showed the same trend with the parameters of cardiac function assessed and upon administration of vitamin E. The results obtained suggest the antioxidative role of vitamin E in alleviating the negative effects induced by artemether-lumefantrine and ciprofloxacin combination treatment, which may be from the impact of free radicals that may have been generated by the combined drugs.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 64%

Assessing the effect of concomitant administration of artemether-lumefantrine and ciprofloxacin on some cardiac parameters in Wistar rats: “The remedial role of vitamin E”

Ndem¹,

Sylvanus²,

Bassey³

et al. 2021

GSC Biol. and Pharm. Sci.

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Adverse effects of Croton urucurana B. exposure during rat pregnancy

Moraes-Souza

Soares

Carmo

et al. 2017

Journal of Ethnopharmacology

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Protective Effect ofAdansonia digitataagainst Isoproterenol-Induced Myocardial Injury in Rats

Ghoneim

Hassan

Mahmoud

et al. 2016

Animal Biotechnology

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The baobab fruit (Adansonia digitata) was analyzed for proximate composition, amino acids, and minerals. The fruit pulp was found to be a good source of carbohydrates, proteins, phenols, and substantial quantities of K, Ca, and Mg. Amino acid analyses revealed high glutamic and aspartic acid, but the sulfur amino acids were the most limited. The present study was designed to investigate the role of Adansonia digitata (Baobab fruit pulp) against isoproterenol induced myocardial oxidative stress in experimental rats by demonstrating the changes in tissue cardiac markers, some antioxidant enzymes, interleukin-1 β (IL-1 β), monocyte chemoattractant protein-1(MCP-1), myeloperoxidase (MPO), Collagen-1, galectin-3, and serum corticosterone. The activities of enzymatic antioxidant glutathione peroxidase (GPX) and non-enzymatic antioxidant reduced glutathione (GSH) in the heart tissue; additionally, histopathological examination of the heart was estimated. Male albino rats were randomly divided into four groups of ten animals each. Group I served as normal control animal. Group II animals received isoproterenol (ISP) (85 mg/kg body weight intraperitonealy (i.p.) to develop myocardial injury. Group III were myocardial oxidative animals treated with Baobab fruit pulp (200 µg/rats/day) for 4 weeks. Group IV received Baobab fruit pulp only. The data suggested an isoproterenol increase in levels of cardiac marker enzymes [creatine kinase MB (CK- MB), lactate dehydrogenase (LDH), and aspartate aminotransferase (AST)], IL-1ß, MCP-1, MPO, Collagen, and galectin-3, with concomitant decrease in the activities GPX and GSH in heart tissue as well as corticosterone in serum. Baobab fruit pulp brings all the parameters to near normal level in ISP-induced myocardial infarction in rats. Histopathological examination of heart tissue of ISP-administered model rat showed infiltration of inflammatory cells and congestion in the blood vessels. However, treatment with Baobab fruit pulp (200 µg/rats/day) showed predominantly normal myocardial structure and no inflammatory cell infiltration. It has been concluded that Baobab fruit pulp has cardio protective effect against ISP-induced oxidative stress in rats.

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Some Morphological Findings on the Heart of Adult Wistar Rats Following Experimental Artesunate Administration

Cited by 4 publications

References 15 publications

Assessing the effect of concomitant administration of artemether-lumefantrine and ciprofloxacin on some cardiac parameters in Wistar rats: “The remedial role of vitamin E”

Assessing the effect of concomitant administration of artemether-lumefantrine and ciprofloxacin on some cardiac parameters in Wistar rats: “The remedial role of vitamin E”

Adverse effects of Croton urucurana B. exposure during rat pregnancy

Protective Effect ofAdansonia digitataagainst Isoproterenol-Induced Myocardial Injury in Rats

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