A family of fuzzy mappings is called higher-order strongly preinvex fuzzy mappings (HOS-preinvex fuzzy mappings), which take the place of generalization of the notion of nonconvexity is introduced through the "fuzzy-max" order among fuzzy numbers. This family properly includes the family of preinvex fuzzy mappings and is included in the family of quasi preinvex fuzzy mappings. With the support of examples, we have discussed some special cases. Some properties are derived and relations among the HOS-preinvex fuzzy mappings, HOS-invex fuzzy mappings, and fuzzy HOS-monotonicity are obtained under some mild conditions. Then, we have shown that optimality conditions of generalized differentiable HOS-preinvex fuzzy mappings and for the sum of generalized differentiable (briefly, G-differentiable) preinvex fuzzy mappings and nongeneralized differentiable HOSpreinvex fuzzy mappings can be distinguished by HOS-fuzzy variational-like inequalities and HOS-fuzzy mixed variational-like inequalities, respectively which can be viewed as novel applications. These inequalities are very interesting outcome of our main results and appear to be new ones. Several exceptional cases are debated. Presented results in this paper can be considered and development of previously established results.