The main objective of this paper was to study the global stability of the positive solutions and the periodic character of the difference equation
xn+1=axn−l+bxn−k+cxn−sdxn−s−e,n=0,1,...,
where the parameters a, b, c, d, and e are positive real numbers and the initial conditions x−t,x−t + 1,...,x−1, x0 are positive real numbers where t = max{l,k,s}. Some numerical examples will be given to explicate our results. Copyright © 2016 John Wiley & Sons, Ltd.