Some Observations on Keratohyalin in Warts

Meirowsky, E.; Behr, G.; Keys, Sandra

doi:10.1111/j.1365-2133.1948.tb11301.x

Cited by 5 publications

(2 citation statements)

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“…Keratohyalin Granules (Table I) The most conspicuous structure within the granular cell is the keratohyalin granule (KHG), named by Waldeyer in 1882 and described by light microscopists as "round specks, coarse irregular lumps, drops or rods" [3]. Some thought they were formed in the granular cell at the expense of mitochondria; others suggested they originated from the Golgi, the ground substance, or from tonofibrils by "fibrillorhexis," as reviewed in [4].…”

Section: -D Reconstructionmentioning

confidence: 98%

Biologic Structure and Function: Perspectives on Morphologic Approaches to the Study of the Granular Layer Keratinocyte.

Holbrook¹

1989

J Invest Dermatol

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S tephen Rothman [1] wrote: "Modern dermatology has been built on the solid pillars of precise macro-and microscopic observation, accurate recording and meaningful interpretation ofthe findings. No natural science can exist without direct observation of natural phenomena, and dermatology has become a great discipline because we have had so many good observers." He went on to state further that "... whereas the immense knowledge acquired by the classical descriptive methods is still rapidly increasing, the application of experimental methods to dermatologic problems is a relatively young and undeveloped approach." These statements acknowledge the importance of observation and description (usually thought of as features of morphology) in clinical dermatology and in descriptive dermatologic research, but were made before he could recognize the value of morphology to experimental studies as well. Unfortunately, Dr. Rothman did not see the remarkable expansion in dermatologic research that has taken place within even the last 20 years, an eta in which descriptive biology and experimental biology are not necessarily separate entities or even parallel concepts. Morphology is simply one of many approaches --sets of tools -that can be used to solve problems in biology.Morphology is often the starting point of an investigation. Understanding the structure of a cell or tissue provides a framework on which other kinds of data can be applied. A morphologic study, however, need not be synonomous with description and qualitative investigation. Many ofthe techniques used by morphologists provide compositional information (presence/absence of a chemical compound) on a structural substrate (location within the cell or tissue) which, in turn, permits interpretation of function. For example, electron microscopic autoradiography can be used to identify the site of incorporation of a radiolabeled amino acid within the tissue and the specific cell and organelle in which it is utilized, or x-ray microanalysis can reveal the elemental composition of parts of cells or different cells within a tissue. Through the use of techniques like morphometry and stereology, morphologic studies can also be quantitative. To continue the example from above, the volume density ofthe radiolabeled organelte can he determined for a cell or tissue by means of selective sampling and prescribed methods of counting, thus allowing for quantitation and statistical analysis when comparing experimental data. Morphology should not have the limited connotation of providing purely descriptive information.The structure and composition of a tissue can provide insight into its function. As stated by Braverman and Braverman [2], "a major aim of biological work is to correlate structure with function in order to understand how tissues work." The goal in the present paper, as indicated by its title, is to support this statement as we review the use of morphologic approaches to understand skin hiology, selecting as an illustration the progress that has been made in understan...

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Section: -D Reconstructionmentioning

confidence: 98%

Biologic Structure and Function: Perspectives on Morphologic Approaches to the Study of the Granular Layer Keratinocyte.

Holbrook¹

1989

J Invest Dermatol

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“…Percival et al (1947) illustrated the bodies, but regarded them as a degeneration preceding involution of the warts. Meirowsky et al (1948) discussed the bodies as inclusions, but their account was MEDICAL JOURNAL DICBOrnSL 915 MEDICAL JOUWML confused by the introduction of the process of " Hornmarkbildung " into the argument. We believe -that the process of " Hornmarkbildung " is quite distinct from the inclusion bodies of type I warts, and occurs in both type I and type B warts.…”

Section: Discussionmentioning

confidence: 99%