Some Observations on the Use of Transplanted Tumors in Radiobiological Research

Scott, O. C. A.

doi:10.2307/3570904

Cited by 24 publications

(7 citation statements)

References 21 publications

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Section: Survival Curve By Td50 Assay Iit Rioti-irradiated or Irradiasupporting

confidence: 71%

“…With more strongly antigenic tumors a much larger apparent shoulder, and much steeper terminal inactivation curve would be expected. The configuration of the survival curve is similar to that reported by Scott (1961) for the Ehrlich tumor. In Figure 3 are presented the results from the present and earlier investigations (Maruyama, 1967) in the study of indirect host contribution to radiosensitivity.…”

Section: Survival Curve By Td50 Assay Iit Rioti-irradiated or Irradiamentioning

confidence: 96%

“…is dose-dependent, has now been shown for this isogeneic tumor. Scott (1961) has observed a similar phenomenon for Ehrlich ascites tumor where an allogeneic rejection mechanism was present, and challenge immunization could easily be produced by pre-treatment. It is, therefore, apparent that either syngeneic preference or allogeneic rejection produce the same net effect upon the radiation cell-survival curve.…”

Section: Survival Curve By Td50 Assay Iit Rioti-irradiated or Irradiamentioning

confidence: 99%

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Dose‐dependent recognition of irradiated isogeneic mouse lymphoma cells: Study by terminal dilution assay

Maruyama¹

1968

Intl Journal of Cancer

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Quantitative dose-response survival curves for mouse leukemic tumor cells in vivo became possible by means of the end-point dilution assay of Hewitt and Wilson (1959), whose results were later confirmed and extended by Berry and Andrews (1961). The loss of reproductive integrity with ionizing radiations thus determined provided quantitative evidence that mammalian tumor cell radiation response in vivo was similar to that of cells irradiated and assayed in vitro by colony-forming ability (Puck and Marcus, 1956). Additional evidence supporting the in vivo survival curves determined by the TD50 method, was provided by the fact that the regrowth of surviving leukemic cells irradiated in vitro could be predicted by cell survival based on the TD50 method and upon the length of life (survival time) of isologous animals receiving transplants of irradiated leukemic cells (Maruyama et al., 1967). In addition, the radiation dose required to render known numbers of leukemic cell nonviable (" sterilizing " dose or SD50 assay) correlated with the TD50 survival curve, provided the recipients were immunologically suppressed by prior whole-body irradiation before they were challenged with the irradiated tumor cells (Maruyama, 1967). In the latter studies it was found that intact animals which were not immunologically suppressed developed a smaller proportion of tumor takes than the pre-irradiated animals.In these experiments, a systematic study of the effect of recipient whole-body X-irradiation before challenge by tumor cells a t the end point of terminal dilution (TD50) assay was investigated. The purpose was to determine the effect and the contribution of weak host-resistance to the overall TD50 survival curve, and the relative effect upon the assay of cells sub-lethally injured by small and large doses of X-irradiation. These results are the subject of this report. MATERIAL AND METHODS AnimalsInbred C57BL/Ka mice about 8-12 weeks of age were used. In each experiment, all recipients were matched for age, sex and size. All animals are descendants of a brother-sister, single-line

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Section: Survival Curve By Td50 Assay Iit Rioti-irradiated or Irradiasupporting

confidence: 71%

Section: Survival Curve By Td50 Assay Iit Rioti-irradiated or Irradiamentioning

confidence: 96%

Section: Survival Curve By Td50 Assay Iit Rioti-irradiated or Irradiamentioning

confidence: 99%

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Dose‐dependent recognition of irradiated isogeneic mouse lymphoma cells: Study by terminal dilution assay

Maruyama¹

1968

Intl Journal of Cancer

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“…We emphasize that at present, limited available experimental data do not permit a critical selection of curve shape for Process 2. However, the proposed approach does fit the data of Scott (1961) and Maruyama (1967Maruyama ( , 1968.…”

Section: Figurementioning

confidence: 99%

“…It does not require a detectable pretreatmentinduced resistance (Maruyama, 1968), although, if resistance can be actively produced (Scott, 1961) it may contribute to the survival curve.…”

mentioning

confidence: 99%

Inactivation of an x‐irradiated tumor by independent processes in in vivo

Maruyama

Ackerman

Khan

1969

Intl Journal of Cancer

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An inactivation model is postulated for tumor-cell radiation response in vivo based upon the response to multiple independent processes. These are intrinsic cell radiation response (Process I), and immunological host resistance (Process 2 ) . A composite dose-efect relationship which arises is described. Experimental data found with the LSA mouse lymphoma are analyzed and show agreement with the model proposed.

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Inhibition and enhancement of the landschütz ascites tumour with lymphoid cells

Hassan

Stuart

1966

J. Pathol.

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Some Observations on the Use of Transplanted Tumors in Radiobiological Research

Cited by 24 publications

References 21 publications

Dose‐dependent recognition of irradiated isogeneic mouse lymphoma cells: Study by terminal dilution assay

Dose‐dependent recognition of irradiated isogeneic mouse lymphoma cells: Study by terminal dilution assay

Inactivation of an x‐irradiated tumor by independent processes in in vivo

Inhibition and enhancement of the landschütz ascites tumour with lymphoid cells

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