Some risk factors for reproductive failures and contribution of Toxoplasma gondii infection in sheep and goats of Central Ethiopia: A cross-sectional study

Gebremedhin, Endrias Zewdu; Agonafir, Abebe; Tessema, Tesfaye Sisay; Tilahun, Getachew; Medhin, Girmay; Vitale, María; Marco, V. Di

doi:10.1016/j.rvsc.2013.08.007

Cited by 48 publications

(47 citation statements)

References 14 publications

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“…As a result, further work is required to assess whether the soil and water on goat farms or in other regions in tropical China are also contaminated by T. gondii oocysts [ 2 ]. In addition, toxoplasmosis can lead to abortion, stillbirth, and mummification in pregnant goats [ 1 , 4 ]. However, the present dataset could not determine whether or not T. gondii infection can significantly increase the risk of abortion in goats in tropical China.…”

Section: Resultsmentioning

confidence: 99%

“…In goats, the main clinical signs of toxoplasmosis are abortion and perinatal death, causing huge economic losses to the goat industry worldwide [ 1 , 4 ]. In spite of the high seroprevalence of T. gondii reported in goats around the world [ 3 , 6 , 10 ], little information is available on the seroprevalence of T. gondii in goats in China [ 9 , 18 , 19 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence ofToxoplasma gondiiin goats in Hunan province, China

Li¹,

Wang

et al. 2016

Parasite

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Toxoplasma gondii infections are prevalent in animals and humans worldwide. In the present investigation, the seroprevalence of T. gondii in goats was investigated in Hunan province, subtropical China between March 2014 and December 2015. A total of 1,028 serum samples collected from 14 administrative regions of Hunan province were evaluated by the indirect hemagglutination test (IHAT) for the detection of specific antibodies. Antibodies to T. gondii were detected in 124 serum samples (12%). The T. gondii seroprevalence ranged from 1.7% to 19% among different regions in subtropical China, and the differences were statistically significant (p < 0.01). The results of the present survey indicated that T. gondii infection is prevalent in goats in Hunan, which poses a potential risk for human infection with T. gondii in this province.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Seroprevalence ofToxoplasma gondiiin goats in Hunan province, China

Li¹,

Wang

et al. 2016

Parasite

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“…Reported risk factors associated with T. gondii infection in goats are age, presence of cats, management systems (i.e. extensive/intensive), source of drinking water and abortion history (Cavalcante et al, 2008;Gebremedhin et al, 2013;Tzanidakis et al, 2012;van Engelen et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Experimental studies on Toxoplasma gondii in the main livestock species (GP/EFSA/BIOHAZ/2013/01) Final report

Opsteegh

Schares

Blaga

et al. 2016

EFS3

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After extensive review of the literature, experimental studies were performed in the main livestock species (cattle, small ruminants, pigs, horses and poultry) to address the main knowledge gaps considering (1) the relationship between detection of antibodies and presence of T. gondii, (2) the anatomical distribution of tissue cysts, and (3) on-farm risk factors for infection. In slaughterhouse studies in cattle and horses, a lack of concordance between detection of antibodies by MAT and detection of T. gondii in tissues by mouse bioassay or MC-PCR was demonstrated. Positive mouse bioassay results were obtained in cattle and horses, indicating a potential infection risk for consumers. DISCLAIMERThe present document has been produced and adopted by the bodies identified above as author(s). In accordance with Article 36 of Regulation (EC) No 178/2002, this task has been carried out exclusively by the author(s) in the context of a grant agreement between the European Food Safety Authority and the author(s). The present document is published complying with the transparency principle to which the Authority is subject. It cannot be considered as an output adopted by the Authority. The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors. The present document has been produced and adopted by the bodies identified above as author(s). In accordance with Article 36 of Regulation (EC) No 178/2002, this task has been carried out exclusively by the author(s) in the context of a grant agreement between the European Food Safety Authority and the author(s). The present document is published complying with the transparency principle to which the Authority is subject. It cannot be considered as an output adopted by the Authority. The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors. 2In naturally infected pigs and chickens the agreement depended on assays and matrices/analytes used, but was considered fair to substantial. Calves, sheep, pigs, chickens and turkeys were experimentally infected with T. gondii. In calves various tissues were tested and T. gondii was recovered, but no clear predilection sites were identified. There was also little variation in parasite load between the different edible tissues (i.e. skeletal muscles) from pigs and sheep. Brain and heart were clearly identified as predilection sites in chickens and turkeys, with higher parasite loads compared to breast, thigh and drumstick muscle. The observation that drumstick, an edible tissue, tested positive in 25% (8/32) of the bioassay positive organic laying hens, indicated a potential risk for consumers. The seroprevalence of T. gondii in Dutch indoor-housed dairy goats appears to be relatively low and was associated with the presence of cats at the farm. I...

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“…In addition, mothers who acquire the infection during pregnancy can transmit T. gondii to the foetus, which may lead to serious consequences such as miscarriage, malformations, blindness and mental alteration . Sheep and goats are the animals in which Toxoplasma causes a higher economic impact, but the infection is as common as in other species, for example humans . The route of transmission to humans is either through consumption of meat containing tissue cysts or ingestion of oocysts released in the faeces of infected cats .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of immune responses induced by rhoptry protein 5 and rhoptry protein 7 DNA vaccines against Toxoplasma gondii

Wang

Lü

Zhou

et al. 2016

Parasite Immunology

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Infection with the protozoan parasite Toxoplasma gondii is widespread, and the organism can cause congenital infections in humans. The horizontal transmission of Toxoplasma is even more common than congenital. An effective vaccine strategy brings the prospect of improving Toxoplasma disease control. Rhoptry protein 5 (ROP5) and ROP7 are potential stimulators of humoral and cellular immune responses. In this study, we constructed a multi-antigenic DNA vaccine expressing ROP5 and ROP7 of T. gondii and compared the protective efficacy to single-gene vaccines and control groups. BALB/c mice were immunized intramuscularly three times. The levels of IgG antibodies and cytokines in mice immunized with the multi-antigenic DNA vaccine (pROP5/ROP7) were significantly higher than those in the control mice. Mice vaccinated with pROP5/ROP7 showed a longer survival time (16 days) than single-gene-immunized mice (11 and 12 days, respectively) or control mice (8 days) after a challenge with 1 × 10(4) tachyzoites of RH strain of T. gondii. Furthermore, after intragastric infection with 20 cysts of PRU strain of T. gondii, the number of brain cysts in mice immunized with pROP5/ROP7 was only 25% of the number in control mice. Our results showed that a DNA vaccine encoding ROP5 and ROP7 significantly enhanced protection against T. gondii challenge.

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Some risk factors for reproductive failures and contribution of Toxoplasma gondii infection in sheep and goats of Central Ethiopia: A cross-sectional study

Cited by 48 publications

References 14 publications

Seroprevalence ofToxoplasma gondiiin goats in Hunan province, China

Seroprevalence ofToxoplasma gondiiin goats in Hunan province, China

Experimental studies on Toxoplasma gondii in the main livestock species (GP/EFSA/BIOHAZ/2013/01) Final report

Evaluation of immune responses induced by rhoptry protein 5 and rhoptry protein 7 DNA vaccines against Toxoplasma gondii

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