Some Systemic Effects of Deuterium Depleted Water on Presenile Female Rats

Джимак, С. С.; Шихлярова, А. И.; Zhukova, Galina V.; Басов, А. А.; Fedulova, Liliya; Куркина, Т. А.; Shirnina, Elena Alekseevna; Protasova, Tatiana P.; Барышев, М. Г.; Тимаков, А. А.

doi:10.5812/jjnpp.83494

Cited by 3 publications

(4 citation statements)

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“…Therefore, in clinical practice, DDW usage in the acute period of the development of pathology requires caution in connection with the risk of a synergistic negative effect on the body’s defense systems (both from the DDW side and from the pathological process [76,93]). Based on the foregoing, it is possible to recommend that people consume DDW during a period of remission of some chronic diseases, or when preparing the organism for extreme impacts (for example, high sports activities), and using it as a geroprotective nutritional factor of holistic geriatric care in presenile period [89]. The DDW also can be used as synergistic anti-inflammatory agent against sepsis with modulated oxidative stress/antioxidant parameters [120], as adjuvant to conventional anticancer treatment [52,105,111], moreover, DDW drinking is effective against hypoxia of the central nervous system and for the prevention of individuals with depression [83,84,85,86,87].…”

Section: Resultsmentioning

confidence: 99%

“…The deuterium substitution by protium in active and allosteric centers of enzymes can alter the speed of catalytic reactions as a result of decrease in activation energy of transition states of the “enzyme-substrate” complex, which can serve as a basis for development of the organism’s metabolic adaptation and lead to occurrence of anti-stress reactions at the system level. In case of substitution of deuterium by protium, not only energy of covalent chemical bonds changes, but there are also differences in the intermolecular interaction forces (for example, due to change in hydrogen bonds energy) between some singular molecules [89]. The noted systemic changes, indicating the restoration of neuroendocrine regulation impaired in animals of pre-senile age, are apparently caused by a decrease of deuterium in blood and visceral organs (liver, kidney, heart), and also by the ease of DDW use as a nutritional factor, which allows us to consider it as a promising solution for holistic geriatric care in a presenile period of ontogenesis.…”

Section: Biological Effects Of Deuterium-depleted Water (Ddw)mentioning

confidence: 99%

“…Changes in the direction and level of expression of isotopic gradients in a body can affect various periods of ontogenesis, including its morphofunctional parameters and activity of biochemical processes, providing short-term and long-term adaptation [78]. These body reactions can increase survival and life functions longevity [89]. The geroprotective influence of DDW was also confirmed on organisms with different levels of organization, including Caenorhabditis elegans ( C. elegans ), which were placed into the liquid medium with δ 2 H = −422‰ and δ 2 H = −229‰.…”

Section: Biological Effects Of Deuterium-depleted Water (Ddw)mentioning

confidence: 99%

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Deuterium-Depleted Water Influence on the Isotope 2H/1H Regulation in Body and Individual Adaptation

et al. 2019

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This review article presents data about the influence of deuterium-depleted water (DDW) on biological systems. It is known that the isotope abundances of natural and bottled waters are variable worldwide. That is why different drinking rations lead to changes of stable isotopes content in body water fluxes in human and animal organisms. Also, intracellular water isotope ratios in living systems depends on metabolic activity and food consumption. We found the 2H/1H gradient in human fluids (δ2H saliva >> δ2H blood plasma > δ2Hbreast milk), which decreases significantly during DDW intake. Moreover, DDW induces several important biological effects in organism (antioxidant, metabolic detoxification, anticancer, rejuvenation, behavior, etc.). Changing the isotope 2H/1H gradient from “2H blood plasma > δ2H visceral organs” to “δ2H blood plasma << δ2H visceral organs” via DDW drinking increases individual adaptation by isotopic shock. The other possible mechanisms of long-term adaptation is DDW influence on the growth rate of cells, enzyme activity and cellular energetics (e.g., stimulation of the mitochondrion activity). In addition, DDW reduces the number of single-stranded DNA breaks and modifies the miRNA profile.

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Section: Resultsmentioning

confidence: 99%

Section: Biological Effects Of Deuterium-depleted Water (Ddw)mentioning

confidence: 99%

Section: Biological Effects Of Deuterium-depleted Water (Ddw)mentioning

confidence: 99%

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Deuterium-Depleted Water Influence on the Isotope 2H/1H Regulation in Body and Individual Adaptation

et al. 2019

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“…The positive biological effects of DDW are quite diverse. Currently, the geroprotective effect of DDW in female rats [ 11 ] and its hepatoprotective effect in rats’ acetaminophen intoxication [ 12 ] has been ascertained. The positive effects of DDW consumption for a range of body protective systems were discovered [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Electrophysiological Activity and Survival Rate of Rats Nervous Tissue Cells Depends on D/H Isotopic Composition of Medium

et al. 2021

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The deuterium content modification in an organism has a neuroprotective effect during the hypoxia model, affecting anxiety, memory and stress resistance. The aim of this work was to elucidate the possible mechanisms of the medium D/H composition modification on nerve cells. We studied the effect of an incubation medium with a 50 ppm deuterium content compared to a medium with 150 ppm on: (1) the activity of Wistar rats’ hippocampus CA1 field neurons, (2) the level of cultured cerebellar neuron death during glucose deprivation and temperature stress, (3) mitochondrial membrane potential (MMP) and the generation of reactive oxygen species in cultures of cerebellar neurons. The results of the analysis showed that the incubation of hippocampal sections in a medium with a 50 ppm deuterium reduced the amplitude of the pop-spike. The restoration of neuron activity was observed when sections were returned to the incubation medium with a 150 ppm deuterium content. An environment with a 50 ppm deuterium did not significantly affect the level of reactive oxygen species in neuron cultures, while MMP decreased by 16–20%. In experiments with glucose deprivation and temperature stress, the medium with 50 ppm increased the death of neurons. Thus, a short exposure of nerve cells in the medium with 50 ppm deuterium acts as an additional stressful factor, which is possibly associated with the violation of the cell energy balance. The decrease in the mitochondrial membrane potential, which is known to be associated with ATP synthesis, indicates that this effect may be associated with the cell energy imbalance. The decrease in the activity of the CA1 field hippocampal neurons may reflect reversible adaptive changes in the operation of fast-reacting ion channels.

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The biological impact of deuterium and therapeutic potential of deuterium-depleted water

Qu,

Xu,

Zhao

et al. 2024

Front. Pharmacol.

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Since its discovery by Harold Urey in 1932, deuterium has attracted increased amounts of attention from the scientific community, with many previous works aimed to uncover its biological effects on living organisms. Existing studies indicate that deuterium, as a relatively rare isotope, is indispensable for maintaining normal cellular function, while its enrichment and depletion can affect living systems at multiple levels, including but not limited to molecules, organelles, cells, organs, and organisms. As an important compound of deuterium, deuterium-depleted water (DDW) possess various special effects, including but not limited to altering cellular metabolism and potentially inhibiting the growth of cancer cells, demonstrating anxiolytic-like behavior, enhancing long-term memory in rats, reducing free radical oxidation, regulating lipid metabolism, harmonizing indices related to diabetes and metabolic syndrome, and alleviating toxic effects caused by cadmium, manganese, and other harmful substances, implying its tremendous potential in anticancer, neuroprotective, antiaging, antioxidant, obesity alleviation, diabetes and metabolic syndrome treatment, anti-inflammatory, and detoxification, thereby drawing extensive attention from researchers. This review comprehensively summarizes the latest progress in deuterium acting on living organisms. We start by providing a snapshot of the distribution of deuterium in nature and the tolerance of various organisms to it. Then, we discussed the impact of deuterium excess and deprivation, in the form of deuterium-enriched water (DEW) and deuterium-depleted water (DDW), on living organisms at different levels. Finally, we focused on the potential of DDW as an adjuvant therapeutic agent for various diseases and disorders.

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Some Systemic Effects of Deuterium Depleted Water on Presenile Female Rats

Cited by 3 publications

References 23 publications

Deuterium-Depleted Water Influence on the Isotope 2H/1H Regulation in Body and Individual Adaptation

Deuterium-Depleted Water Influence on the Isotope 2H/1H Regulation in Body and Individual Adaptation

Electrophysiological Activity and Survival Rate of Rats Nervous Tissue Cells Depends on D/H Isotopic Composition of Medium

The biological impact of deuterium and therapeutic potential of deuterium-depleted water

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