Some Toxicological Observations on Paraphenylene Diamine (Hair Dye) in Rats and Chickens

Saad, Hosam A.; ., H. M. Mousa; Ali, Bushra

doi:10.3923/pjbs.2000.953.956

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…PPD is mainly used as an element of oxidative hair coloring products and temporary tattoos to fasten the dyeing process and produce a black color [11][12][13]. It can penetrate the hair shaft and undergo oxidative reactions, causing hair discoloration [14].…”

Section: Introductionmentioning

confidence: 99%

“…While the paste form of henna can be applied directly on the skin, the powder form is mixed with water before its application. PPD is mainly used as an element of oxidative hair coloring products and temporary tattoos to fasten the dyeing process and produce a black color [ 11 - 13 ]. It can penetrate the hair shaft and undergo oxidative reactions, causing hair discoloration [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Erythematous Linear Lesion on the Course of Superficial Fibular Nerve After the Topical Application of Black Henna: A Case Report

Alkandari¹,

Alawadhi²,

Alawadhi³

et al. 2023

Cureus

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Henna is commonly used in body arts, where it produces orange-brown color. It is often mixed with chemicals such as para-phenylenediamine (PPD) to fasten the dyeing process and produce a black color. However, PPD has many allergic and toxic effects. We present a case of henna-induced cutaneous neuritis, which is not reported before. A 27-year-old female presented to our hospital, complaining of pain in her left great toe after applying black henna. Upon examination, the proximal nail fold was inflamed, and an erythematous non-palpable tender lesion was noticed on the dorsum of the foot. The lesion had an inverted-Y shape that was confined to the course of the superficial fibular nerve. Cutaneous nerve inflammation was favored after excluding all the anatomical structures in the region. Black henna should be avoided since it contains PPD, which can be absorbed through the skin and affect the underlying cutaneous nerves.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Erythematous Linear Lesion on the Course of Superficial Fibular Nerve After the Topical Application of Black Henna: A Case Report

Alkandari¹,

Alawadhi²,

Alawadhi³

et al. 2023

Cureus

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Some toxicological health hazards associated with subchronic dermal exposure to paraphenylene-diamine (PPD): An experimental study

Abd-ElZaher

Fawzy

Ahmed

et al. 2012

Egyptian Journal of Forensic Sciences

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Repeated Dermal Paraphenylenediamine Exposure Induces Systemic Biochemical and Histological Changes in Adult male Albino Rats

Elhelaly

Shaker

2014

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Paraphenylenediamine (PPD) is a synthetic compound that is widely used as a hair dye. This study investigated biochemical and histological effects after repeated PPD dermal application. 30 adult male albino rats (200± 20gms) were classified into two groups; group I, (control group) included negative and positive control subgroups, each consisted of 10 rats and group II (tested group). Tested group was subjected to repeated topical PPD application in a dose of 10mg/kg for 90 days. All groups were investigated for these laboratory biochemical parameters: Serum creatine phosphokinase CPK-MB, aspartate (AST) and alanine transferases (ALT), serum creatinine (S. Creat.), blood urea nitrogen (BUN) as well as serum potassium. All the mentioned parameters showed significant increase when compared to control group. ECG was done and revealed significant decrease of pulse rate and significant prolongation of PR, QRS and QT intervals in tested group. In-addition, to biochemical and ECG investigations; histological examination was done for; cardiac, hepatic, renal and testicular tissues. Cardiac, hepatic, renal, and testicular tissues of tested group showed evident changes. These changes were more obvious in Cardiac, renal, and testicular tissues when compared to control. Aim of the work This study aimed to investigate systemic toxicities of PPD especially after repeated dermal exposure. Materials and methods Material The tested chemical paraphenylenediamine (PPD), CAS No (106-50-3) was purchased from Sigma Chemical Company in the form of white powder then dissolved in distilled water. Animals Thirty adult male albino rats were conducting in this study and classified into two groups: I-Control group (group I) This group was sub-classified into two subgroups each consisted of 10 rats, as follows: P

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Some Toxicological Observations on Paraphenylene Diamine (Hair Dye) in Rats and Chickens

Cited by 4 publications

References 7 publications

Erythematous Linear Lesion on the Course of Superficial Fibular Nerve After the Topical Application of Black Henna: A Case Report

Erythematous Linear Lesion on the Course of Superficial Fibular Nerve After the Topical Application of Black Henna: A Case Report

Some toxicological health hazards associated with subchronic dermal exposure to paraphenylene-diamine (PPD): An experimental study

Repeated Dermal Paraphenylenediamine Exposure Induces Systemic Biochemical and Histological Changes in Adult male Albino Rats

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