Something “hairy” in juvenile hormone signaling for mosquito reproduction

Jindra, Marek

doi:10.1073/pnas.1524895113

Cited by 5 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It also has been demonstrated that rising hemolymph JH titers stimulate other behavioral traits, including host-seeking in newly-eclosed mosquitoes. For instance, it has been reported that JH activates Met protein in the formation of a transcription repressor complex with proteins Hairy and Groucho; the interactions between these proteins is essential for female maturation (Jindra, 2016), and consequently influences the mating behavior. In our RNA-Seq data, we detected a Drosophila homolog to protein Groucho, which was downregulated, albeit at low level (log2FC = −0.5).…”

Section: Discussionmentioning

confidence: 99%

Responses of the Housefly, Musca domestica, to the Hytrosavirus Replication: Impacts on Host's Vitellogenesis and Immunity

Kariithi

et al. 2017

Front. Microbiol.

View full text Add to dashboard Cite

Hytrosaviridae family members replicate in the salivary glands (SGs) of their adult dipteran hosts and are transmitted to uninfected hosts via saliva during feeding. Despite inducing similar gross symptoms (SG hypertrophy; SGH), hytrosaviruses (SGHVs) have distinct pathobiologies, including sex-ratio distortions in tsetse flies and refusal of infected housefly females to copulate. Via unknown mechanism(s), SGHV replication in other tissues results in reduced fecundity in tsetse flies and total shutdown of vitellogenesis and sterility in housefly females. We hypothesized that vitellogenesis shutdown was caused by virus-induced modulation of hormonal titers. Here, we used RNA-Seq to investigate virus-induced modulation of host genes/pathways in healthy and virus-infected houseflies, and we validated expression of modulated genes (n = 23) by RT-qPCR. We also evaluated the levels and activities of hemolymph AMPs, levels of endogenous sesquiterpenoids, and impacts of exogenous hormones on ovarian development in viremic females. Of the 973 housefly unigenes that were significantly modulated (padj ≤ 0.01, log2FC ≤ −2.0 or ≥ 2.0), 446 and 527 genes were downregulated and upregulated, respectively. While the most downregulated genes were related to reproduction (embryogenesis/oogenesis), the repertoire of upregulated genes was overrepresented by genes related to non-self recognition, ubiquitin-protease system, cytoskeletal traffic, cellular proliferation, development and movement, and snRNA processing. Overall, the virus, Musca domestica salivary gland hytrosavirus (MdSGHV), induced the upregulation of various components of the siRNA, innate antimicrobial immune, and autophagy pathways. We show that MdSGHV undergo limited morphogenesis in the corpora allata/corpora cardiaca (CA/CC) complex of M. domestica. MdSGHV replication in CA/CC potentially explains the significant reduction of hemolymph sesquiterpenoids levels, the refusal to mate, and the complete shutdown of egg development in viremic females. Notably, hormonal rescue of vitellogenesis did not result in egg production. The mechanism underlying MdSGHV-induced sterility has yet to be resolved.

show abstract

Section: Discussionmentioning

confidence: 99%

Responses of the Housefly, Musca domestica, to the Hytrosavirus Replication: Impacts on Host's Vitellogenesis and Immunity

Kariithi

et al. 2017

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Juvenile hormone (JH) plays critical roles in development, metamorphosis, reproduction, migration and pheromone production in insects [ 1 , 2 , 3 ]. In migratory insects, the onset of migratory behaviour usually occurs in the pre-reproduction period, which is initiated by sexually immature adults.…”

Section: Introductionmentioning

confidence: 99%

Effects of Juvenile Hormone Analog and Days after Emergence on the Reproduction of Oriental Armyworm, Mythimna separata (Lepidoptera: Noctuidae) Populations

Zeng

Zhang

et al. 2022

Insects

View full text Add to dashboard Cite

Mythimna separata (Walker) is a main cereal crop pest that causes extensive damage to the world grain production. The effects of juvenile hormone on M. separata populations remain poorly understood. Here, we explored how JH analog (JHA) affected reproductive traits of both migrant and resident populations in this pest. Our results showed that the influence of JHA treatment on reproduction depended on adult age (days after emergence) of exposure to JHA and populations. Exposure of M. separata residents to JHA (methoprene) on day 1 and day 2 after adult emergence significantly shortened the pre-oviposition period, but increased the lifetime fecundity, mating frequency and grade of ovarian development compared to the controls. However, M. separata migrants exposed to JHA only on day 1 facilitated their reproduction, resulting in a reduction in the pre-oviposition period but an increase in lifetime fecundity, mating frequency and grade of ovarian development. In addition, exposure to JHA from day 2 to day 4 did not significantly affect the ovarian and reproductive development in both migrant and resident populations. These results indicated that the first two days after adult emergence were the sensitive period for residents. In contrast, only the first day after adult emergence was the sensitive stage for migrants. Our findings will contribute to a better understanding of JHA function on M. separata populations.

show abstract

“…The molting and metamorphosis of insects are mainly regulated by juvenile hormone (JH) and molting hormone (MH), which not only regulate growth and development, but also play a role in reproduction (Flatt et al., 2008), especially JH (Coviella et al., 2002; Dubrovsky, 2005; Jindra et al., 2013). The signal transduction of these two hormones is regulated by both neuropeptides and environmental signals (Jindra, 2016; Yamanaka et al., 2013). JH is also a gonadotropin, which can regulate and promote egg yolk production in insects (Robinson & Vargo, 1997).…”

Section: Introductionmentioning

confidence: 99%

Influence of an elevated CO₂level on life history parameters and hormone pathway or vitellogenin metabolism of the brown planthopper

Wang

Liu

Wang

et al. 2021

J Applied Entomology

View full text Add to dashboard Cite

The growth, development and reproduction of herbivorous insects could be altered due to changes in quality and quantity of their host plants under elevated CO2. The brown planthopper, Nilaparvata lugens, is one of the most serious and destructive economic pests in rice growing areas in Asia. In this study, we investigated the effect of elevated CO2 on the growth, development and reproduction of N. lugens and, in particular, on the hormonal regulation of the transcription factors in N. lugens. The results indicated that compared with ambient CO2, elevated CO2 significantly shortened the duration of egg and nymph, longevity of female adults and total adults, and significantly decreased the weight of adults; besides, elevated CO2 significantly improved the fecundity of female adults, egg hatching rata and the transcription levels of Vg. The relative expression levels of JHMAT‐ and FAMeT‐regulated synthesis of JH were first down‐regulated and then up‐regulated with the development of the 5th instar nymph of N. lugens under elevated CO2. In addition, the relative expression level of cyp314a1 played an important role in synthesis of ecdysone was up‐regulated in the 5th instar nymph of N. lugens under elevated CO2. We have demonstrated that elevated CO2 could accelerate the development and improve the reproduction of N. lugens, which is related to the transcription levels of JH, MH and Vg.

show abstract

Something “hairy” in juvenile hormone signaling for mosquito reproduction

Cited by 5 publications

References 15 publications

Responses of the Housefly, Musca domestica, to the Hytrosavirus Replication: Impacts on Host's Vitellogenesis and Immunity

Responses of the Housefly, Musca domestica, to the Hytrosavirus Replication: Impacts on Host's Vitellogenesis and Immunity

Effects of Juvenile Hormone Analog and Days after Emergence on the Reproduction of Oriental Armyworm, Mythimna separata (Lepidoptera: Noctuidae) Populations

Influence of an elevated CO₂level on life history parameters and hormone pathway or vitellogenin metabolism of the brown planthopper

Contact Info

Product

Resources

About

Something “hairy” in juvenile hormone signaling for mosquito reproduction

Cited by 5 publications

References 15 publications

Responses of the Housefly, Musca domestica, to the Hytrosavirus Replication: Impacts on Host's Vitellogenesis and Immunity

Responses of the Housefly, Musca domestica, to the Hytrosavirus Replication: Impacts on Host's Vitellogenesis and Immunity

Effects of Juvenile Hormone Analog and Days after Emergence on the Reproduction of Oriental Armyworm, Mythimna separata (Lepidoptera: Noctuidae) Populations

Influence of an elevated CO2level on life history parameters and hormone pathway or vitellogenin metabolism of the brown planthopper

Contact Info

Product

Resources

About

Influence of an elevated CO₂level on life history parameters and hormone pathway or vitellogenin metabolism of the brown planthopper