Sonication-assisted preparation of CaO nanoparticles for antibacterial agents

Tang, Zhen‐Xing; Yu, Zeping; Zhang, Zhiliang; Zhang, Xinyi; Pan, Qinghua; Shi, Lu-E

doi:10.1590/s0100-40422013000700002

Cited by 33 publications

(17 citation statements)

References 13 publications

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“…CaO nanoparticle synthesis (SNp) was reported by Tang et al [ 32 ]. The Ca(NO 3 ) 2 ·4H 2 O (2M) was dissolved in ethylene glycol (25 mL), and then NaOH (4.2 M) was added to the solution under sonication.…”

Section: Methodsmentioning

confidence: 99%

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Mechanical and Antimicrobial Polyethylene Composites with CaO Nanoparticles

et al. 2020

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Low-density polyethylene composites containing different sizes of calcium oxide (CaO) nanoparticles were obtained by melt mixing. The CaO nanoparticles were synthesized by either the sol-gel or sonication methods, obtaining two different sizes: ca. 55 nm and 25 nm. These nanoparticles were used either as-synthesized or were modified organically on the surface with oleic acid (Mod-CaO), at concentrations of 3, 5, and 10 wt% in the polymer. The Mod-CaO nanoparticles of 25 nm can act as nucleating agents, increasing the polymer’s crystallinity. The Young’s Modulus increased with the Mod-CaO nanoparticles, rendering higher reinforcement effects with an increase as high as 36%. The reduction in Escherichia coli bacteria in the nanocomposites increased with the amount of CaO nanoparticles, the size reduction, and the surface modification. The highest antimicrobial behavior was found in the composites with a Mod-CaO of 25 nm, presenting a reduction of 99.99%. This strong antimicrobial effect can be associated with the release of the Ca2+ from the composites, as studied for the composite with 10 wt% nanoparticles. The ion release was dependent on the size of the nanoparticles and their surface modification. These findings show that CaO nanoparticles are an excellent alternative as an antimicrobial filler in polymer nanocomposites to be applied for food packaging or medical devices.

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Section: Methodsmentioning

confidence: 99%

“…There are some studies of the effect of the incorporation of CaCO 3 in a polyethylene (PE) matrix on the mechanical and rheological properties [ 29 , 30 , 31 ]. The addition of 10 vol% of nano-sized calcium carbonate increased both the yield stress and Young’s modulus of PE [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanical and Antimicrobial Polyethylene Composites with CaO Nanoparticles

et al. 2020

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“…Different studies were discussed on the preparation methods for Ca(OH) 2 nanoparticles including sonochemical technique [4,21], hydrogen plasma-metal reaction [5], sol-gel method [22][23][24], hydrothermal method [25], homogeneous and heterogeneous phase syntheses [26][27][28][29] and precipitation method [30,31]. However, these techniques come with its own limitations which are high cost of organic solvents and chemical reagents that required as CaO starting precursor.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of clamshell derived Ca(OH)2 nano-particles via simple surfactant-hydration treatment

Asikin-Mijan

Taufiq‐Yap

Lee

2015

Chemical Engineering Journal

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“…Although it may be difficult to explain these findings, there are some important aspects related to the characteristics and processing conditions of nanoparticles that could have influenced this outcome. First, it has been revealed that the size of nanoparticles may affect their antibacterial potential, with the smaller the size, the greater the activity [44]; second, calcination (i.e., a thermal treating process) of CaO nanoparticles was revealed to improve bacterial killing when compared to untreated nanoparticles [45]. The nanoparticles used in the present study were situated in the nano-size range (Figure 3a), showing an average size of 67 nm, which, in fact, was considerably higher than the 18 nm-sized nanoparticles used in the study by Roy et al [24].…”

Section: Discussionmentioning

confidence: 99%

“…This difference in size of nanoparticles may, perhaps, explain the negative antibacterial activity obtained in our study; however, it does not elucidate why an inhibition halo could be seen for the gelatin-based matrix during the first experiment. However, in the third experiment, CaO nanoparticles were calcined as previously described [45] and then used for preparation of new CaO suspensions and tested against S. aureus . Once again, no antibacterial effect was observed.…”

Section: Discussionmentioning

confidence: 99%

Synthesis and characterization of CaO-loaded electrospun matrices for bone tissue engineering

et al. 2015

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Objectives To synthesize and characterize biodegradable polymer-based matrices loaded with CaO-nanoparticles for osteomyelitis treatment and bone tissue engineering. Materials and methods Poly(ε-caprolactone) (PCL) and PCL/gelatin (1:1, w/w) solutions containing CaO nanoparticles were electrospun into fibrous matrices. Scanning (SEM) and transmission (TEM) electron microscopy, Fourier Transformed Infrared (FTIR), Energy Dispersive X-ray Spectroscopy (EDS), contact angle (CA), tensile testing, and antibacterial activity (agar diffusion assay) against Staphylococcus aureus (S. aureus) were performed. Osteoprecursor cell (MC3T3-E1) response (i.e., viability and alkaline phosphatase expression/ALP) and infiltration into the matrices were evaluated. Results CaO nanoparticles were successfully incorporated into the fibers, with the median fiber diameter decreasing after CaO incorporation. The CA decreased with the 0addition of CaO, and the presence of gelatin made the matrix very hydrophilic (CA = 0°). Increasing CaO concentrations progressively reduced the mechanical properties (p≤0.030). CaO-loaded matrices did not display consistent antibacterial activity. MC3T3-E1 cell viability demonstrated the highest levels for CaO-loaded matrices containing gelatin after 7 days in culture. An increased ALP expression was consistently seen for PCL/CaO matrices when compared to PCL and gelatin-containing counterparts. Conclusions Despite inconsistent antibacterial activity, CaO nanoparticles can be effectively loaded into PCL or PCL/gelatin fibers without negatively affecting the overall performance of the matrices. More importantly, CaO incorporation enhanced cell viability as well as differentiation capacity, as demonstrated by an increased ALP expression. Clinical significance CaO-loaded electrospun matrices show potential for applications in bone tissue engineering.

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Sonication-assisted preparation of CaO nanoparticles for antibacterial agents

Cited by 33 publications

References 13 publications

Mechanical and Antimicrobial Polyethylene Composites with CaO Nanoparticles

Mechanical and Antimicrobial Polyethylene Composites with CaO Nanoparticles

Synthesis of clamshell derived Ca(OH)2 nano-particles via simple surfactant-hydration treatment

Synthesis and characterization of CaO-loaded electrospun matrices for bone tissue engineering

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