Sonochemical synthesis of highly luminescent silver complexes: Photophysical properties and preliminary in vitro antitumor and antibacterial assays

Synthesis, Structural Characterization and Antimicrobial Evaluation of Ruthenium Complexes with Heteroaromatic Carboxylic Acids

“…Biologically active metal complexes have gained special significance due to the need for the prevention of resistance of bacterial strains. Recently, several Cu(II), Ga(III), Zn(II), Mn(II), Ag(I), Au(III) and Ru(II) complexes with bioactive ligands have been tested as potential antibiofilm and antimicrobial agents . Among above mentioned metal complexes, ruthenium compounds are promising for medicinal and biotechnological applications as they present unique properties: (i) multiple oxidation states (II, III and IV), which are accessible in physiological conditions; (ii) favorable ligand‐exchange kinetics; (iii) multiple cytotoxic routes involving the competing processes of extracellular protein binding (active transport), due to the ability to mimic iron and cellular uptake (passive diffusion); (iv) different molecular pathways involving the concurrent intercalation and covalent binding with DNA and binding to extracellular sites inducing conformational modifications; (v) numerous synthetic opportunities for modifying the biological activity which depends on both the oxidation state of the metal center and the associated ligands surrounding it.…”

Synthesis and antimicrobial evaluation of a pyrazoline-pyridine silver(I) complex: DNA-interaction and anti-biofilm activity

“…Among the tested pathogens, higher activity was observed against the Gram-negative species compared to the Gram-positive, a result that is not entirely unusual, as higher activity for Gramnegative has been reported before (Nawaz et al 2011;Njogu, et al 2017). This is, however, the exact opposite to the results reported by Favarin et al (2019) which indicates the significance of the ligand nature in the specific antimicrobial activity of the silver complexes. Moreover, it exhibits outstanding antifungal activity.…”

“…Furthermore, recent work on silver(I) derivatives of several thioligands showed significant antimicrobial activity and low cellular toxicity with a high percent of cell viability (Aulakh, et al 2018(Aulakh, et al , 2020. Additionally, Favarin et al (2019) recently described the synthesis of novel mononuclear silver(I) complexes based on thiocarbamoyl-pyrazoline ligands which were proved selective for Gram-positive bacteria, after being tested against two standard bacterial strains: S. aureus ATCC 25,923 and E. coli ATCC 25,922. The MICs of free ligands were in the range of 125-375 lg/mL, whereas the values from 1.95 to 15.6 lg/mL obtained for silver complexes are indicative of good activity, evidencing that metalation potentiated the antimicrobial activity.…”

Comparative Antibacterial Activity of Some Selected Seaweed Extracts from Agadir Coastal Regions in Morocco

“…To quantify the antibacterial activity, MIC and MBC were determined using a broth micro dilution method and tetrazolium salt, 2,3,5-Triphenyltetrazolium Chloride (TTC) (Favarin et al, 2019). Mother solutions obtained for each seaweed extract tested were dissolved in methanol and then serially diluted in 96-well microtiter plates to obtain concentrations ranging from 0.05 to 30 mg/ml.…”