Sonodynamic and chemodynamic therapy based on organic/organometallic sensitizers

Stanene‐Based Nanosheets for β‐Elemene Delivery and Ultrasound‐Mediated Combination Cancer Therapy

“…Thea dvantageous US-triggered generation of ROSf or SDT was originally showcased with organic small molecule sonosensitizers,s uch as porphyrins,t heir derivatives,a nd others. [5,9,10] However,t heir long-lasting skin sensitivity,l ow chemical stability,p oor tumor accumulation, and high dosedependent toxicity have hindered their further applications in clinical settings.Additionally,the hydrophobic nature of most of these small molecules makes them easily aggregate in the physiological environment, thereby reducing their bioavailability and ROSg eneration efficiency. [7] To solve the unmet needs the past years have seen af ocus on the synthesis of biocompatible inorganic nanomaterial-based sonosensitizers such as titanium dioxide (TiO 2 ), zinc oxide (ZnO) nanomaterials,a nd their nanocomposites.…”

Photoactivatable nanogenerators of reactive species for cancer therapy

“…ROS can destroy tumor cells through multifactorial mechanisms, including oxidizing the biological macromolecules, destroying angiogenesis to cut off the supply of nutrients to tumor cells [ 36 , 37 ]. Typically, five therapeutic strategies including radiation therapy [ [38] , [39] , [40] , [41] ], chemodynamic therapy [ [42] , [43] , [44] , [45] , [46] ], sonodynamic therapy [ [47] , [48] , [49] , [50] ], bioreductive chemotherapeutics (e.g., tirapazamine, TPZ) [ [51] , [52] , [53] , [54] ], and photodynamic therapy (PDT) [ [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] ] can generate ROS. Among all these approaches, PDT-based cancer therapies have been extensively exploited.…”

The chemodynamic antibacterial effect of MnOX nanosheet decorated silicon nanowire arrays

“…ROS can be produced through the catalysis of metals and metal oxides 20,21 , electron transfer in redox reactions, and normal mitochondrial metabolism 22 , etc. Excitation conditions include chemodynamics 23,24 , photodynamics 25,26 and acoustic dynamics 27,28 . The generation of ROS by metal oxide nanosheets often requires external energy stimulation 29,30 .…”