“Sonoelasticity” images derived from ultrasound signals in mechanically vibrated tissues

Lerner, Robert M.; Huang, Sung‐Rung; Parker, Kevin J.

doi:10.1016/0301-5629(90)90002-t

Cited by 425 publications

(204 citation statements)

References 12 publications

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“…65,66 The complexity of strain distribution within the insertions may facilitate the transfer of tensile strain from the ligament to bone through this interfacial fibrocartilage tissue. 37 In addition, collagen fibers extending from ligament into bone at the insertions may transmit tensile, shear and compressive stresses through the fibrocartilage zones. 8 Our findings and the developed methods will be used in future studies to elucidate the structurefunction relationship at the ligament-bone interface.…”

Section: Discussionmentioning

confidence: 99%

“…Elastography or elasticity imaging has been used to map mechanical responses and calculate material properties by comparing ultrasound or MR images acquired before and after mechanical loading. This technique, developed in the early 1990s as an alternative tool for early tumor detection and diagnosis based on the principle of palpation, 37,38 has been extensively validated and utilized in intravascular and cardiovascular applications in vivo, 39,40 as well as in the guidance of thermal therapy procedures. 41 Elastography has been used to determine both elastic and mechanical properties of tissues.…”

Section: Introductionmentioning

confidence: 99%

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Elastographic imaging of strain distribution in the anterior cruciate ligament and at the ligament–bone insertions

Spalazzi

Gallina

Fung-Kee-Fung

et al. 2006

Journal Orthopaedic Research

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ABSTRACT:The anterior cruciate ligament (ACL) functions as a mechanical stabilizer in the tibiofemoral joint, and is the most commonly injured knee ligament. To improve the clinical outcome of tendon grafts used for ACL reconstructions, our long-term goal is to promote graft-bone integration via the regeneration of the native ligament-bone interface. An understanding of strain distribution at this interface is crucial for functional scaffold design and clinical evaluation. Experimental determination, however, has been difficult due to the small length scale of the insertion sites. This study utilizes ultrasound elastography to characterize the response of the ACL and ACL-bone interface under tension. Specifically, bovine tibiofemoral joints were mounted on a material testing system and loaded in tension while radiofrequency (RF) data were acquired at 5 MHz. Axial strain elastograms between RF frames and a reference frame were generated using crosscorrelation and recorrelation techniques. Elastographic analyses revealed that when the joint was loaded in tension, complex strains with both compressive and tensile components occurred at the tibial insertion, with higher strains found at the insertion sites. In addition, the displacement was greatest at the ACL proper and decreased in value gradually from ligament to bone, likely a reflection of the matrix organization at the ligament-bone interface. Our results indicate that elastography is a novel method that can be readily used to characterize the mechanical properties of the ACL and its insertions into bone. ß

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Elastographic imaging of strain distribution in the anterior cruciate ligament and at the ligament–bone insertions

Spalazzi

Gallina

Fung-Kee-Fung

et al. 2006

Journal Orthopaedic Research

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“…Elastography is a newly developed dynamic technique that uses US to provide an estimation of tissue stiffness by measuring the degree of distortion under the application of an external force. US elastography has been applied to study the hardness/elasticity of nodules to differentiate malignant from benign lesions [14]- [17]. The thyroid gland is well positioned for elastographic examination: It is easily assessable and can be efficiently compressed against underlying anatomic structures by using a US probe [18].…”

Section: Introductionmentioning

confidence: 99%

Real Time Ultrasound Elastography for the Differentiation of Benign and Malignant Thyroid Nodules

Eltyib¹,

Awad²,

Elsayed³

et al. 2014

OJMI

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The purpose of this study was to evaluate the predictive value of real-time ultrasound elastography (RUE) in differentiating benign from malignant thyroid nodules, with fine needle aspiration cytology analysis as the reference standard. A total of 78 consecutive patients with thyroid nodules who were selected for fine needle aspiration biopsies were examined in this prospective study. 78 nodules in these patients were examined by conventional ultrasound, and ultrasound elastography. The final diagnosis was obtained from cytological findings. Tissue stiffness on ultrasound elastography was scored from 1 (low stiffness over the entire nodule) to 5 (high stiffness over the entire nodule and surrounding tissue). On real-time ultrasound elastography, 47 of 62 benign nodules (76%) had a score of 1 or 2, whereas 15 of 16 malignant nodules had a score of 3 to 5, with sensitivity of 93.7%, specificity of 90%, a positive predictive value of 71%, and a negative predictive value of 98%. Real-time ultrasound elastography is a promising imaging technique that is useful in the differential diagnosis of thyroid cancer. Utilization of ultrasound elastography could reduce the rate of thyroid biopsies because of its high elasticity being highly associated with benign cytology.

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“…Ultrasoundelastography (USE) is a technique that allows improved characterization of tissues/nodules, based on their elasticity and firmness [8,9]. USE was first used to characterize breast lumps and later thyroid nodules [10].…”

Section: Introductionmentioning

confidence: 99%

Ultrasoundelastography: Can it provide valid information for differentiation of benign and malignant thyroid nodules?

Raggiunti

Capone²,

Franchi

et al. 2011

Journal of Ultrasound

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KEYWORDSThyroid; Thyroid sonography; Thyroid nodules; Sonoelastography; FNAC.Abstract Ultrasoundelastography (USE) is a new imaging technique that is performed with a normal ultrasound transducer. It provides improved characterization of a tissue or nodule based on the latter's elasticity and stiffness. The aim of the present, prospective study was to assess the validity of USE in characterizing thyroid nodules. USE patterns were analyzed in light of nodule cytology (British Thyroid Association classification) to determine whether these patterns can be used to decide whether or not fine-needle aspiration cytology (FNAC) is indicated. We examined a consecutive series of 617 thyroid nodules in patients referred for the first time to the Endocrinology Unit of Atri Hospital (Atri, [TE]). Patients underwent ultrasonographic and USE examinations of their thyroid nodules, which were then subjected to FNAC. All nodules with Thy 1 cytology were excluded, leaving 567 nodules for analysis. USE findings were classified on the basis of the degree and distribution of elasticity within the lesion: four patterns were identified (1, 2, 3a, 3b, or 4).None of the nodules with Thy 4 cytology (malignant) had USE pattern 1 or 2; patterns 3 and 4 were associated with higher cytologic grades. In conclusion, USE provides additional information on thyroid nodules, which can be used with ultrasound features of the nodules, to decide whether FNAC is indicated. In fact, patterns 1 and 2 do not seem to be associated with Thy 4 cytology.Sommario L'Elastosonografia (ESG) è una nuova tecnica d'immagine che, utilizzando una normale sonda ecografica, consente una migliore caratterizzazione tissutale, fornendo informazioni su elasticità e durezza di un tessuto o di un nodulo.L'obiettivo di questo studio prospettico è quello di valutare l'effettiva validità della ESG nel caratterizzare i noduli tiroidei, associando il pattern elastosonografico al grading citologico e, * Corresponding author.E-mail address: raggibruno@virgilio.it (B. Raggiunti). quindi, valutare se eseguire o meno l'agoaspirazione del nodulo tiroideo, in base al pattern ESG. Sono stati studiati, in serie successiva, 617 noduli tiroidei di pazienti afferiti per la prima volta presso la nostra UO di Endocrinologia del P.O. di Atri (TE), sottoposti ad esame ecografico, elastosonografico e ad agoaspirato con ago sottile (FNAC), per lo studio citologico. Tutti i noduli che al referto citologico presentavano un grado Thy 1 sono stati esclusi dallo studio, pertanto sono stati esaminati 567 noduli. Lo score elastosonografico utilizzato prevede 5 patterns cromatografici (1; 2; 3a; 3b e 4) a seconda della distribuzione di tessuto più o meno elastico all'interno del nodulo. I risultati dell'ESG hanno evidenziato che nessun nodulo con citologico Thy 4 presenta un grado elastosonografico 1 o 2; passando ai patterns elastosonografici 3 e 4 si assiste ad una crescita concomitante del grading citologico. In conclusione l'ESG può essere considerata un ulteriore parametro, in associazione alle caratt...

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“Sonoelasticity” images derived from ultrasound signals in mechanically vibrated tissues

Cited by 425 publications

References 12 publications

Elastographic imaging of strain distribution in the anterior cruciate ligament and at the ligament–bone insertions

Elastographic imaging of strain distribution in the anterior cruciate ligament and at the ligament–bone insertions

Real Time Ultrasound Elastography for the Differentiation of Benign and Malignant Thyroid Nodules

Ultrasoundelastography: Can it provide valid information for differentiation of benign and malignant thyroid nodules?

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