Sonographic and Pathologic Image Analysis of Pure Mucinous Carcinoma of the Breast

Kaoku, Setsuko; Konishi, Eiichi; Fujimoto, Yasuhisa; Tohno, Eriko; Shiina, Tsuyoshi; Kondo, Kengo; Yamazaki, Sanae; Kajihara, Mariko; Shinkura, Nobuhiko; Yanagisawa, Akio

doi:10.1016/j.ultrasmedbio.2013.02.014

Cited by 20 publications

(30 citation statements)

References 11 publications

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“…In terms of US features, it has been reported that US features do not help to differentiate between benign and malignant MLLs [ 15 ]. However, certain findings were predominant in the benign lesions considered in our study.…”

Section: Discussionmentioning

confidence: 99%

A pure mucocele-like lesion of the breast diagnosed on ultrasonography-guided core-needle biopsy: is imaging follow-up sufficient?

Park

Kim

2014

Ultrasonography

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Purpose:To evaluate the upgrade rate of ultrasonography (US)-guided core-needle biopsy (CNB) of the breast for a pure mucocele-like lesion (MLL), to evaluate the clinical and radiologic features, and to correlate the image-pathologic features further on to guide the management of MLL.Methods:Between January 2003 and February 2013, 14-gauge US-guided CNB was performed in 18,111 cases. Thirty-two cases associated with MLL were identified, and five cases of MLLs associated with breast carcinoma or with other high-risk breast lesions (i.e., atypical ductal hyperplasia [ADH], papillary lesions, lobular carcinoma in situ, and radial scar complex) were excluded. Among these 27 pure MLLs, 21 cases with surgical or vacuum-assisted excision (VAE) pathology were included in our study. Medical records, mammograms, and ultrasonograms were reviewed for the clinical and radiologic features of the cases.Results:Among the 21 cases with pure MLLs at CNB, the final pathology showed a 0% proportion of cases upgraded to malignancy. All the 21 cases with either surgical or VAE pathology were benign MLLs including three cases of focal involvement of ADH (14.3%). The common features were mammographic features of microcalcifications that were round in shape and had a grouped distribution. The US features included oval shape, circumscribed margin, parallel orientation, complex solid and cystic echo pattern, no posterior feature, and complex solid and cystic echoic masses. The predominant Breast Imaging Reporting and Data System (BIRADS) category was 4A. All the lesions showed image-pathologic concordance.Conclusion:For pure MLL on US-guided CNB with image-pathologic concordance, close imaging follow-up might be considered instead of surgical excision.

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Section: Discussionmentioning

confidence: 99%

A pure mucocele-like lesion of the breast diagnosed on ultrasonography-guided core-needle biopsy: is imaging follow-up sufficient?

Park

Kim

2014

Ultrasonography

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“…PMBCs comprise less than 2% of all breast cancers [3], and they tend to have less involvement of axillary lymph nodes and a better prognosis than MMBCs [4].FAs, which contain both fibrous and epithelial components, are the most common benign neoplasm of the female breast [5]. About 40% of FAs have myxoid or edematous changes histopathologically [6].…”

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confidence: 99%

Differentiation between Pure Mucinous Breast Carcinomas and Fibroadenomas with Strong High-Signal Intensity on T2-Weighted Images from Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Luo

et al. 2017

Breast Care

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Objective: This study aimed to identify characteristics that can differentiate between pure mucinous breast carcinomas (PMBCs) and fibroadenomas (FAs) with strong high-signal intensity on T2-weighted images (T2-SHi) from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Methods: The DCE-MRI tumor characteristics were compared and analyzed between 35 PMBCs and 70 FAs with T2-SHi. Results: Multivariate analysis revealed that delayed enhancement pattern was the only significant independent predictor (p = 0.007). Conclusion: A delayed enhancement pattern is the most reliable characteristic for differentiating PMBCs from FAs with T2-SHi from DCE-MRI.

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“…In the present study, it was identified in 82.4% (14/17) of MUMPC and 67.4% (29/43) of cPMBC. In a different study conducted by Kaoku, irregular shape was found in 90.9% (10/11) of PMBC [ 15 ]. Lam et al [ 16 ] have suggested that the irregular shape on sonography is associated with MBC having a less favorable histologic grade.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that microlobulation, one of the diagnostic features, could be seen in more MBCs [ 15 , 16 ]. According to Lam et al [ 16 ], the presence of cystic and solid components (37.5%, 12/32) and distal enhancement (43.8%, 14/32) in MBC are important sonographic features for diagnosis.…”

Section: Discussionmentioning

confidence: 99%

The sonographic findings of micropapillary pattern in pure mucinous carcinoma of the breast

2018

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BackgroundThe aim of this study was to describe the sonographic features of pure mucinous carcinoma with micropapillary pattern (MUMPC) and compare them with conventional pure mucinous breast carcinoma without micropapillary architecture (cPMBC) and mixed mucinous breast carcinoma (MMBC).MethodsEighty-eight patients (17 MUMPCs, 43 cPMBCs, and 28 MMBCs) were included in the study. Sonographic features according to the Breast Imaging Reporting and Data System (BI-RADS) lexicon for ultrasound (US) were recorded and analyzed for each patient. The age, sonographic lesion size, menstrual status, mass location, palpation, tenderness, and axillary lymph node metastasis (LNM) were also analyzed.ResultsMost of the MUMPCs showed an irregular shape (82.4%, 14/17), a parallel orientation (94.1%, 16/17), a non-circumscribed margin (88.2%, 15/17), and distal acoustic enhancement (88.2%, 15/17). Furthermore, MUMPC had mixed cystic and solid components (35.3%, 6/17) and hypoechoic (29.4%, 5/17) and isoechoic (35.3%, 6/17) structures, with calcification (29.4%, 5/17) and blood flow (41.2%, 7/17) within the tumor. The differences in sonographic features were not found between the MUMPC and cPMBC and between the MUMPC and MMBC. Moreover, there was no significant difference between the three groups based on age, menstrual status, mass location, palpation, and tenderness (p > 0.05). Similar axillary LNMs were observed between MUMPC and cPMBC (p > 0.05), but both MUMPC and cPMBC were statistically different from MMBC (p < 0.05), so as the lesion size.ConclusionsAt this particular stage, it is challenging to distinguish MUMPC from cPMBC and MMBC on ultrasound according to the BI-RADS-US lexicon.

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Sonographic and Pathologic Image Analysis of Pure Mucinous Carcinoma of the Breast

Cited by 20 publications

References 11 publications

A pure mucocele-like lesion of the breast diagnosed on ultrasonography-guided core-needle biopsy: is imaging follow-up sufficient?

A pure mucocele-like lesion of the breast diagnosed on ultrasonography-guided core-needle biopsy: is imaging follow-up sufficient?

Differentiation between Pure Mucinous Breast Carcinomas and Fibroadenomas with Strong High-Signal Intensity on T2-Weighted Images from Dynamic Contrast-Enhanced Magnetic Resonance Imaging

The sonographic findings of micropapillary pattern in pure mucinous carcinoma of the breast

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