Sonographic and pathological features of metaplastic squamous cell carcinoma of the breast: a case series

Abstract

Objective The aim of this study was to evaluate the sonographic features and to compare the sonographic findings with the pathologic features. Methods The sonographic and pathological features of all patients were retrospectively reviewed. Results All these 9 patients presented with a palpable breast mass first found by the patient before presentation. The median diameters were 3.67 cm. On two-dimensional imaging, 8 masses showed mixed echogenicity with both solid and cystic components, and only 1 mass showed hypoechoic. All the masses had irregular shapes. 1 mass had indistinct margin and 8 masses had microlobulated margins. Calcifications was seen in 1 mass. On color Doppler flow imaging, 8 masses had high vascularity with high resistance index; 5 masses had grade III blood flow signal; 3 masses had grade II blood flow signal. On histopathological examination, 5 masses were adenocarcinoma with squamous metaplasia, and 4 masses were pure SCC. On immunohistochemical staining, estrogen receptors (ER), progesterone receptors (PR) and human epidermal growth factor receptor (HER2) were negative in 5 masses. There were 2 patients with lymph node metastasis. Conclusions Most of the sonographic features of MSCC were mixed echogenicity with central cystic components, posterior echo enhancement, abundant vascularity with high resistance.

Sonographic and clinicopathologic features of metaplastic breast carcinoma and infiltrating ductal carcinoma: a comparative single-center cohort study

“…Upon sonographic examination, the most distinctive indications of MBC have been reported to be the presence of masses exhibiting a complex cystic and solid echo pattern, as well as posterior acoustic enhancement ( 31 - 35 ). Our research revealed that 50.0% of MBC lesions exhibited complex cystic and solid components, while 95.0% of MBCs were characterized by posterior acoustic enhancement, which aligns with prior research ( 33 ). The cystic areas might be caused by necrosis, hemorrhage, or cystic degeneration ( 13 ).…”

Primary squamous cell carcinoma of the breast: a case report

“…SCC of the breast is a histological subtype of metaplastic carcinoma with similar clinical features to non-specific ER-negative invasive breast cancer [ 1 ], despite reports of HER2 overexpression [ 10 , 11 ]. Most cases present as palpable masses and are identified as mass lesions on ultrasonography or mammography [ 12 ]. Additional symptoms besides breast lumps, such as skin ulcers and fungal infections can affect the chest wall [ 4 ].…”

Breast Metaplastic Carcinoma With Osteosarcomatous Differentiation: A Case Report and literature Review

“…We described different presentations of immunohistochemistry in different component, to expect helping therapy. 7 , 8 SATB2 is a marker of osteoblastic differentiation in bone tumors. 9 So the positive of SATB2 confirmed osseous differentiation of the tumor.…”