Sonographic assessment of infectious diseases of the gastrointestinal tract: from scanning to diagnosis

Revzin, Margarita V.; Moshiri, Mariam; Bokhari, Jamal; Pellerito, John S.; Menias, Christine O.

doi:10.1007/s00261-019-02358-9

Cited by 10 publications

(4 citation statements)

References 84 publications

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“…Ultrasound has great potential for the treatment of infectious diseases, especially when limited resources are available [ 145 ]. Abdominal [ 146 ], gastrointestinal [ 147 ], lung [ 148 ], and intrauterine ultrasound imaging [ 149 ] are widely used for the screening of clinical infectious diseases. Additionally, with the development of nanotechnology-based drug delivery systems, ultrasound-induced drug delivery has shown much potential against bacteria, biofilms, pathogenic viruses, and other microbial diseases [ 150 , 151 ].…”

Section: Various Biomedical Application Of Ultrasound-responsive Polymentioning

confidence: 99%

Ultrasound-responsive polymer-based drug delivery systems

Wei

Cornel

2021

Drug Deliv. and Transl. Res.

108

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Ultrasound-responsive polymeric materials have received a tremendous amount of attention from scientists for several decades. Compared to other stimuli-responsive materials (such as UV-, thermal-, and pH-responsive materials), these smart materials are more applicable since they allow more efficient drug delivery and targeted treatment by fairly non-invasive means. This review describes the recent advances of such ultrasound-responsive polymer-based drug delivery systems and illustrates various applications. More specifically, the mechanism of ultrasound-induced drug delivery, typical formulations, and biomedical applications (tumor therapy, disruption of blood-brain barrier, fighting infectious diseases, transdermal drug delivery, and enhanced thrombolysis) are summarized. Finally, a perspective on the future research directions for the development of ultrasound-responsive polymeric materials to facilitate a clinical translation is given.

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Section: Various Biomedical Application Of Ultrasound-responsive Polymentioning

confidence: 99%

Ultrasound-responsive polymer-based drug delivery systems

Wei

Cornel

2021

Drug Deliv. and Transl. Res.

108

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“…Importantly, all these IUS features may overlap with IBD, and IUS alone cannot diagnose GI infections. Therefore, an ultrasound control can be performed in these patients to exclude IBD [ 10 ].…”

Section: Screening and Diagnosis Of Ibdmentioning

confidence: 99%

Intestinal Ultrasound in Inflammatory Bowel Disease: A Valuable and Increasingly Important Tool

Frias-Gomes¹,

Torres²,

Palmela³

2021

GE Port J Gastroenterol

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Background: Intestinal ultrasound is emerging as a non-invasive tool for monitoring disease activity in inflammatory bowel disease patients due to its low cost, excellent safety profile, and availability. Herein, we comprehensively review the role of intestinal ultrasound in the management of these patients. Summary: Intestinal ultrasound has a good accuracy in the diagnosis of Crohn’s disease, as well as in the assessment of disease activity, extent, and evaluating disease-related complications, namely strictures, fistulae, and abscesses. Even though not fully validated, several scores have been developed to assess disease activity using ultrasound. Importantly, intestinal ultrasound can also be used to assess response to treatment. Changes in ultrasonographic parameters are observed as early as 4 weeks after treatment initiation and persist during short- and long-term follow-up. Additionally, Crohn’s disease patients with no ultrasound improvement seem to be at a higher risk of therapy intensification, need for steroids, hospitalisation, or even surgery. Similarly to Crohn’s disease, intestinal ultrasound has a good performance in the diagnosis, activity, and disease extent assessment in ulcerative colitis patients. In fact, in patients with severe acute colitis, higher bowel wall thickness at admission is associated with the need for salvage therapy and the absence of a significant decrease in this parameter may predict the need for colectomy. Short-term data also evidence the role of intestinal ultrasound in evaluating therapy response, with ultrasound changes observed after 2 weeks of treatment and significant improvement after 12 weeks of follow-up in ulcerative colitis. Key Messages: Intestinal ultrasound is a valuable tool to assess disease activity and complications, and to monitor response to therapy. Even though longer prospective data are warranted, intestinal ultrasound may lead to a change in the paradigm of inflammatory bowel disease management as it can be used in a point-of-care setting, enabling earlier intervention if needed.

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Section: Introductionmentioning

confidence: 99%

“…Ultrasonography (US) is widely used as an initial screening modality for acute abdominal pain due to its noninvasiveness and easy accessibility [ 26 , 27 , 28 ]. Recent technological advances in US machines have led to dramatic improvements in contrast, spatial, and temporal resolutions for bowel imaging [ 26 , 27 , 28 , 29 ]. Ileal diverticula are commonly seen near the ileocecal valve, possibly due to increased intraluminal pressure and reversion of the blood vessels to an arcade system with larger vasa recta [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Acute Ileal Diverticulitis: Computed Tomography and Ultrasound Findings

et al. 2023

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Background: Acute ileal diverticulitis is a rare disease mimicking acute appendicitis. Inaccurate diagnosis with a low prevalence and nonspecific symptoms leads to delayed or improper management. Methods: This retrospective study aimed to investigate the characteristic sonographic (US) and computed tomography (CT) findings with clinical features in seventeen patients with acute ileal diverticulitis diagnosed between March 2002 and August 2017. Results: The most common symptom was abdominal pain (82.3%, 14/17) localized to the right lower quadrant (RLQ) in 14 patients. The characteristic CT findings of acute ileal diverticulitis were ileal wall thickening (100%, 17/17), identification of inflamed diverticulum at the mesenteric side (94.1%, 16/17), and surrounding mesenteric fat infiltration (100%, 17/17). The typical US findings were outpouching diverticular sac connecting to the ileum (100%, 17/17), peridiverticular inflamed fat (100%, 17/17), ileal wall thickening with preserved layering pattern (94.1%, 16/17), and increased color flow to the diverticulum and surrounding inflamed fat on color Doppler imaging (100%, 17/17). The perforation group had a significantly longer hospital stay than non-perforation group (p = 0.002). In conclusion, acute ileal diverticulitis has characteristic CT and US findings that allow radiologists to accurately diagnose the disease.

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Sonographic assessment of infectious diseases of the gastrointestinal tract: from scanning to diagnosis

Cited by 10 publications

References 84 publications

Ultrasound-responsive polymer-based drug delivery systems

Ultrasound-responsive polymer-based drug delivery systems

Intestinal Ultrasound in Inflammatory Bowel Disease: A Valuable and Increasingly Important Tool

Acute Ileal Diverticulitis: Computed Tomography and Ultrasound Findings

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