Sonographic Assessment of Spleen Size in Turkish Migrants With Familial Mediterranean Fever in Germany

Örnek, Ahmet; Kurucay, Mustafa; Henning, B. F.; Pagonas, Nikolaos; Schlottmann, Renate; Schmidt, Wolfgang E.; Giese, Arnd

doi:10.7863/ultra.33.11.1991

Cited by 3 publications

(3 citation statements)

References 38 publications

(60 reference statements)

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“…A recent study performed on Turkish migrants with FMF in Germany showed a larger splenic volume, in patients with FMF compared to healthy controls using sonography. 22 Due to clinical phenotype among some patients who are heterozygous for FMF, it can potentially be missed or stay undiagnosed. Further studies should highlight FMF as a potential cause of moderate splenomegaly in our Mediterranean population.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic assessment of splenic volume and its correlation with body parameters in a Jordanian population

Badran

Kalbouneh

Al-Hadidi

et al. 2015

SMJ

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Objectives:To estimate normal linear dimensions and volume of spleen in Jordanians using ultrasonography, and to correlate splenic volume with age and body parameters: height, weight, body surface area (BSA), and body mass index (BMI).Methods:A prospective pilot study was conducted on 205 volunteers (115 males and 90 females) not known to have any conditions likely to be associated with splenomegaly. The study was performed at the Radiology Department, Jordanian University Hospital, Amman, Jordan, between December 2013 and August 2014. All linear dimensions of spleen were measured, and splenic volume (index) was calculated using the standard prolate ellipsoid formula (length × width × depth × 0.523). The splenic volume was then analyzed with age and body parameters using the Pearson’s correlation coefficient.Results:The mean (± SD) splenic dimensions were 10.72±1.37 cm in length, 7.40±1.52 cm in width, 4.40±1.47 cm in depth, and 184.15±79.56 cm3 in volume. Men had larger spleens than women (p<0.0001). Age had no significant effect on spleen volume (r=0.11, p=0.12). There was a significant moderate positive correlation (p<0.0001), using Pearson’s correlation coefficient, between the spleen volume, and other parameters (height, weight, BSA, and BMI), with correlation coefficients exceeding 0.3.Conclusion:A local reference of spleen dimensions was established with a different range of values reported previously.

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Section: Discussionmentioning

confidence: 99%

Ultrasonographic assessment of splenic volume and its correlation with body parameters in a Jordanian population

Badran

Kalbouneh

Al-Hadidi

et al. 2015

SMJ

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“…Amyloid A accumulates mainly in the kidney, as well as the heart, spleen, thyroid and gastrointestinal tract. Mild splenomegaly is a finding in younger adults (83). In one half of the children with FMF splenomegaly is detectable by ultrasound (84).…”

Section: (V) Congestionmentioning

confidence: 99%

Splenomegaly in Children and Adolescents

Suttorp

Classen²

2021

Front. Pediatr.

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In contrast to other lymphoid tissues making up the immune system, the spleen as its biggest organ is directly linked into the blood circulation. Beside its main task to filter out microorganism, proteins, and overaged or pathologically altered blood cells, also humoral and cellular immune responses are initiated in this organ. The spleen is not palpable during a physical examination in most but not all healthy patients. A correct diagnosis of splenomegaly in children and adolescents must take into account age-dependent size reference values. Ultrasound examination is nowadays used to measure the spleen size and to judge on reasons for morphological alterations in associated with an increase in organ size. An enormous amount of possible causes has to be put in consideration if splenomegaly is diagnosed. Among these are infectious agents, hematologic disorders, infiltrative diseases, hyperplasia of the white pulp, congestion, and changes in the composition and structure of the white pulp by immunologically mediated diseases. This review attempts to discuss a comprehensive list of differential diagnoses to be considered clinically in children and young adolescents.

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“…Некоторые авторы даже выделяют характерные черты, позволяющие дифференцировать ОАБ при ССЛ от острого аппендицита, при котором наблюдаются более высокие уровни микроальбуминурии и β2-микроглобулина в моче, а также прокальцитонина [13,27,28]. В диагностике ССЛ помогает УЗИ, при котором определяется значительное увеличение селезенки (>11 см), имеющее высокую специфичность для острой атаки ССЛ [13,29], как и лимфоаденит и перитонит в острый период. В исследовании S. Masatlioglu и соавт.…”

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Abdominal syndrome in monogenic autoinflammatory disease – is it just a familial Mediterranean fever?

Олеговна¹,

Федоров²,

Volf

2020

Sovremennaâ revmatologiâ

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Gastrointestinal (GI) manifestations, such as abdominal pain, nausea, vomiting, and diarrhea, are common autoinflammatory disease (AID) symptoms. The abdominal symptomatology reflecting serositis is one of the most important classification and diagnostic criteria for the classic monogenic AID (MAID) – familial Mediterranean fever (FMF). Failure to timely diagnose FMF frequently leads to unjustified surgical interventions. Other periodic fevers may also present as abdominal symptoms; however, the latter are outside their diagnostic features. These diseases include, first of all, tumor necrosis factor receptor-associated periodic syndrome (TRAPS). Interleukin 1 (IL1) inhibitors serve as the major targeted drugs for the treatment of TRAPS. Russia has registered the IL1 inhibitor canakinumab that prevents the development of organ damages, including those in the GI tract. The paper describes a clinical case of the classic manifestations of TRAPS (fever, rash, periorbital edema, arthritis, and elevated levels of acutephase inflammatory markers) concurrent with severe abdominalgia during attacks and with the development of severe peritoneal adhesions, which led to bowel perforation and emergency surgical intervention. The prolonged persistence of inflammatory attacks before the initiation of therapy, as well as violation of the IL1 inhibitor administration regimen facilitated the development of an urgent exacerbation. Thus, TRAPS should be included in the differential diagnostic circle for patients with severe gastrointestinal manifestations characterized by an attack-like course. These patients need timely prescription of targeted therapy, strict adherence to the dosing and intervals between drug administrations, and careful monitoring to prevent serious complications with the visceral organs, including the gastrointestinal tract, and their immediate correction.

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Sonographic Assessment of Spleen Size in Turkish Migrants With Familial Mediterranean Fever in Germany

Cited by 3 publications

References 38 publications

Ultrasonographic assessment of splenic volume and its correlation with body parameters in a Jordanian population

Ultrasonographic assessment of splenic volume and its correlation with body parameters in a Jordanian population

Splenomegaly in Children and Adolescents

Abdominal syndrome in monogenic autoinflammatory disease – is it just a familial Mediterranean fever?

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