Sonographic Prevalence of Liver Steatosis and Biliary Tract Stones in Patients with Inflammatory Bowel Disease: Study of 511 Subjects at a Single Center

Bargiggia, S.; Maconi, Giovanni; Elli, Marco; Molteni, Paola; Ardizzone, Sandro; Parente, F.; Todaro, Ivan; Greco, Salvatore; Manzionna, G.; Porro, G. Bianchi

doi:10.1097/00004836-200305000-00012

Cited by 139 publications

(149 citation statements)

References 15 publications

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“…A incidência de manifestações hepáticas em pacientes com DII varia de 5-95% (7,29,35,46,47,48,49). Em nossa casuística encontramos uma incidência de 14,9%, sendo 13,2% para RCU e 16,9% para DC.…”

Section: Rcu + Crohnunclassified

“…Broomé et al (1990) observaram que 50% dos pacientes com RCU e que não apresentavam alterações bioquímicas hepáticas, apresentavam algum tipo de alteração histológica (49). Bargiggia et al(2003) evidenciaram anormalidades ultra-sonográficas em 55,1% dos pacientes com DII investigados sistematicamente(DC-54,3% e RCU-55,9%) (48).…”

Section: Rcu + Crohnunclassified

“…Bargiggia et al(2003) evidenciaram anormalidades ultra-sonográficas em 55,1% dos pacientes com DII investigados sistematicamente(DC-54,3% e RCU-55,9%) (48).…”

Section: Rcu + Crohnunclassified

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Manifestações extra-intestinais em doença de Crohn e retocolite ulcerativa: prevalência e correlação com o diagnóstico, extensão, atividade, tempo de evolução da doença

Mota

Kiss

Teixeira

et al. 2007

Rev bras. colo-proctol.

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Section: Rcu + Crohnunclassified

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Manifestações extra-intestinais em doença de Crohn e retocolite ulcerativa: prevalência e correlação com o diagnóstico, extensão, atividade, tempo de evolução da doença

Mota

Kiss

Teixeira

et al. 2007

Rev bras. colo-proctol.

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“…They are characterized by heavy course, frequent development of extraintestinal complications, and involvement of different organs and systems in pathological process including liver injury (Loftus, 1997;Danese, 2005;Navaneethan, 2010). Steatosis and steatohepatitis (SH) are considered the most common liver diseases, that appear in 15-88% of patients suffering from IBD, according to literature resources, and have favorable course (Dutt, 1983;Aitola, 1994;Broome, 1990;Bargiggia, 2003;Adamopoulos, 2006;Gaitini, 2011).…”

Section: Introductionmentioning

confidence: 99%

Steatohepatitis in patients with inflammatory bowel diseases in Karelia

Dudanova¹,

Larina²,

Prokapovich³

et al. 2014

Journal of Biomedical Technologies

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Abstract. Background. Inflammatory bowel diseases (IBD) may be accompanied by the development of steatohepatitis (SH), but its frequency and the dependence of liver damage on the form and severity of IBD can vary considerably according to observations of different researchers. The aim of the study was to evaluate the incidence and severity of SH in patients with ulcerative colitis (UC) and Crohn's disease (CD) in the Republic of Karelia.Materials and methods. Sixty six patients with IBD (48 with UC and 18 with CD) were examined before administration of an anti-inflammatory therapy in order to exclude possible druginduced liver damage. There were 35 males (53.0%) and 31 females (47.0%), the mean age was 45.3±5.2. IBD was diagnosed on the basis of clinical, laboratory and instrumental data (colonoscopy, upper gastrointestinal endoscopy with biopsies of tissue/lesions, computed tomography enterography, hydromagnetic resonance imaging of intestine, barium double-contrast enema radiographic studies). SH was diagnosed relying on laboratory tests such as ALT / AST (alanine/aspartate amino transferase), bilirubin, alkaline phosphatase and others, ultrasonography data and histological studies of liver biopsies or autopsies, and after the exclusion of hepatitis of viral and autoimmune origin.Results. SH was revealed in 19 (28.8%) patients with IBD: in 10 (55.6%) CD patients and in 9 (18.8%) UC patients. SH in IBD was characterized by mild (in 90.0% of patients) and moderate (in 10.0%) inflammatory activity. Direct relationship between the development of SH and the activity of IBD (r=0.60, p<0.05) or extent of IBD (r=0.69, p<0.5) was observed. SH in CD patients was affected mainly by malabsorption, malnutrition and deterioration of enterohepatic circulation of bile acids, while SH in UC patients was affected predominantly by alteration in the intestinal microflora. Steatohepatitis activity decreased significantly in 4-8 weeks as a result of antiinflammatory treatment of bowel diseases without special hepatoprotective therapy.Conclusion. Steatohepatitis, which aroused in 30.5% of patients with inflammatory bowel diseases, was characterized by mild activity and related to the extent of intestinal damage and inflammatory activity.

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“…The estimated prevalence of NAFLD is as high as 40% in patients with inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD) [2]. Although multiple etiologies have been proposed to explain this increased NAFLD prevalence, including the presence of the metabolic syndrome (MetS), intestinal inflammation and dysbiosis, and the medications used to treat IBD [3], the underlying cause(s) have yet to be determined.…”

mentioning

confidence: 99%

Increased Prevalence of NAFLD in IBD Patients

Gaidos

Fuchs

2017

Dig Dis Sci

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Sonographic Prevalence of Liver Steatosis and Biliary Tract Stones in Patients with Inflammatory Bowel Disease: Study of 511 Subjects at a Single Center

Abstract: The prevalence of liver enlargement and liver steatosis was higher among IBD patients. The prevalence of gallstones was increased in CD patients only. This risk was related to age, female sex, and previous surgery.

Cited by 139 publications

References 15 publications

Manifestações extra-intestinais em doença de Crohn e retocolite ulcerativa: prevalência e correlação com o diagnóstico, extensão, atividade, tempo de evolução da doença

Manifestações extra-intestinais em doença de Crohn e retocolite ulcerativa: prevalência e correlação com o diagnóstico, extensão, atividade, tempo de evolução da doença

Steatohepatitis in patients with inflammatory bowel diseases in Karelia

Increased Prevalence of NAFLD in IBD Patients

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