2011
DOI: 10.1089/hum.2011.076
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Sonoporation Delivery of Interleukin-27 Gene Therapy Efficiently Reduces Prostate Tumor Cell Growth In Vivo

Abstract: We have examined the potential of a novel cytokine, interleukin-27 (IL-27), for gene therapy of prostate cancer. IL-27 is the most recently characterized member of the family of heterodimeric IL-12-related cytokines and has shown promise in halting tumor growth and mediating tumor regression in several cancer models. In the present study, we examined the efficacy of a new mode of gene delivery to prostate tumors: low-frequency ultrasound irradiation or "sonoporation." We also examined the potential of IL-27 ge… Show more

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Cited by 65 publications
(68 citation statements)
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“…In light of this activity, exciting results have been reported against melanoma and breast cancer using IL-12 and IL-27 sequential gene therapy through intramuscular electroporation (75). More recently, the efficacy of IL-27 as an antitumor agent against prostate cancer using sonoporation, a new mode of gene delivery that involves low-frequency ultrasound irradiation, has been reported (76). Investigators used 3 models of immune-competent prostate adenocarcinoma, and detailed characterizations of tumor growth reduction, gene profile expression, and effector cellular profiles were reported.…”
Section: Cytokines Of the Il-12 Family: Potential Clinical Implicationsmentioning
confidence: 99%
“…In light of this activity, exciting results have been reported against melanoma and breast cancer using IL-12 and IL-27 sequential gene therapy through intramuscular electroporation (75). More recently, the efficacy of IL-27 as an antitumor agent against prostate cancer using sonoporation, a new mode of gene delivery that involves low-frequency ultrasound irradiation, has been reported (76). Investigators used 3 models of immune-competent prostate adenocarcinoma, and detailed characterizations of tumor growth reduction, gene profile expression, and effector cellular profiles were reported.…”
Section: Cytokines Of the Il-12 Family: Potential Clinical Implicationsmentioning
confidence: 99%
“…This motif is therefore likely to be a factor in the potent antitumor activities of IL-27, which are known to involve CD8 T cells (11)(12)(13)(14)(15)(16)(17)(18)(19)60). As bone marrow niches are also preferred sites for the metastasis of several solid tumors and for blood cell malignancies (61,62), the conjunction of potent antitumoral activities and of bone binding properties of IL-27 could be beneficial therapeutically (11)(12)(13)(14)(15)(16)(17)(18)(19). This could be particularly relevant for multiple myeloma treatment as the IL-27 therapeutic activity on this neoplasia is accompanied by a capacity to inhibit osteoclastogenesis (17,20,63) and IL-17 production, which is known to promote myeloma growth (64).…”
Section: Discussionmentioning
confidence: 99%
“…IL-27 plays an important role in the resolution of inflammation in different models of infection and has marked beneficial effects in the experimental autoimmune encephalitis model of multiple sclerosis (5)(6)(7)(8)(9)(10). IL-27 has also been shown to have potent beneficial antitumor effects in leukemia and solid cancer models in mice (11)(12)(13)(14)(15)(16)(17)(18)(19). Moreover, IL-27 has been described to inhibit osteoclastogenesis and to protect against bone destructive disorders (20).…”
mentioning
confidence: 99%
“…Sonoporation is an emerging and promising physical method for cancer gene therapy that typically operates at a frequency of 1-35 MHz, and has several advantages over other nonphysical methods of nucleic acid delivery; for example, sonoporation also has the ability to deliver drugs or small molecules (19). However, the transfer efficiency depends on ultrasound frequency, intensity (20) and the number of microbubbles (21).…”
Section: Introductionmentioning
confidence: 99%