“…The obtained DoxyNPs were purified by repeated washing and centrifugation steps ( Figure 1 A). The mechanism of DoxyNP formation was previously elucidated [ 28 ]. Briefly, the OH radicals generated by the acoustic cavitation induce structural changes in the doxycycline aromatic molecules.…”
Section: Resultsmentioning
confidence: 99%
“…The radical-mediated oxidation of doxycycline results in the cleavage of amine/amide moieties and hydroxylation and dimerization processes ( Figure 1 B). The obtained amphiphilic molecules ultimately self-assemble into nanoparticles during cavitation bubble collapse due to intermolecular interactions, i.e., H-bonding and π – π interactions [ 28 ].…”
Section: Resultsmentioning
confidence: 99%
“…We recently reported that the transformation of the non-selective anthracycline doxorubicin into a tumor-selective nanodrug could be achieved by the reaction between OH radicals and biomolecules on the surface of cavitation bubbles generated using high-frequency ultrasound [ 27 ]. We have also shown that the antibiotic doxycycline is responsive to high-frequency ultrasound (490 kHz), and a carrier-free nano-antibiotic with good antimicrobial and antioxidant activity was obtained using this innovative ultrasonic strategy [ 28 ].…”
Ultrasound-based engineering of carrier-free nanodrugs by supramolecular self-assembly has recently emerged as an innovative and environmentally friendly synthetic approach. By applying high-frequency sound waves (490 kHz) in aqueous solutions, the transformation of small chemotherapeutic and antibiotic drug molecules into carrier-free nanodrugs with anticancer and antimicrobial activities was recently achieved. The transformation of the antibiotic drug molecules, i.e., doxycycline, into stable nanodrugs (~130 nm) with selective anticancer activity was achieved without requiring organic solvents, chemical agents, or surfactants. The obtained nanodrug exhibited reactive oxygen species (ROS)-mediated cytotoxicity on human breast cancer (MDA-MB 231 cells) but a negligible antiproliferative effect on healthy fibroblast cells. Imaging by super-resolution microscopy (STORM) provided insights into the intracellular trafficking and endosomal escape of the nanodrugs. Overall, these findings suggest that small antibiotic drugs can be transformed into chemotherapeutic nanodrugs with high selectivity against cancer cells.
“…The obtained DoxyNPs were purified by repeated washing and centrifugation steps ( Figure 1 A). The mechanism of DoxyNP formation was previously elucidated [ 28 ]. Briefly, the OH radicals generated by the acoustic cavitation induce structural changes in the doxycycline aromatic molecules.…”
Section: Resultsmentioning
confidence: 99%
“…The radical-mediated oxidation of doxycycline results in the cleavage of amine/amide moieties and hydroxylation and dimerization processes ( Figure 1 B). The obtained amphiphilic molecules ultimately self-assemble into nanoparticles during cavitation bubble collapse due to intermolecular interactions, i.e., H-bonding and π – π interactions [ 28 ].…”
Section: Resultsmentioning
confidence: 99%
“…We recently reported that the transformation of the non-selective anthracycline doxorubicin into a tumor-selective nanodrug could be achieved by the reaction between OH radicals and biomolecules on the surface of cavitation bubbles generated using high-frequency ultrasound [ 27 ]. We have also shown that the antibiotic doxycycline is responsive to high-frequency ultrasound (490 kHz), and a carrier-free nano-antibiotic with good antimicrobial and antioxidant activity was obtained using this innovative ultrasonic strategy [ 28 ].…”
Ultrasound-based engineering of carrier-free nanodrugs by supramolecular self-assembly has recently emerged as an innovative and environmentally friendly synthetic approach. By applying high-frequency sound waves (490 kHz) in aqueous solutions, the transformation of small chemotherapeutic and antibiotic drug molecules into carrier-free nanodrugs with anticancer and antimicrobial activities was recently achieved. The transformation of the antibiotic drug molecules, i.e., doxycycline, into stable nanodrugs (~130 nm) with selective anticancer activity was achieved without requiring organic solvents, chemical agents, or surfactants. The obtained nanodrug exhibited reactive oxygen species (ROS)-mediated cytotoxicity on human breast cancer (MDA-MB 231 cells) but a negligible antiproliferative effect on healthy fibroblast cells. Imaging by super-resolution microscopy (STORM) provided insights into the intracellular trafficking and endosomal escape of the nanodrugs. Overall, these findings suggest that small antibiotic drugs can be transformed into chemotherapeutic nanodrugs with high selectivity against cancer cells.
“… Fig. 2 Schematic diagram showing the sonochemically modified flavonoid compound mechanisms and its activity (Adapted from [57] , [58] and modified). Fig.…”
Section: Antimicrobial Benefits Of Usae Bioactives From Various Food ...mentioning
“…Transforming small-molecule antibiotics into carrier-free nanoantibiotics represents an opportunity for developing new multifunctional therapeutic agents. Zhu et al [4] introduced a strategy for fabricating carrier-free doxycycline nanodrugs using high frequency ultrasound. The morphology of obtained particles could be finely controlled by tuning the applied ultrasonic powers.…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
