Sophora flavescens Ait.: Traditional usage, phytochemistry and pharmacology of an important traditional Chinese medicine

He, Xirui; Fang, Jugao; Huang, Libei; Wang, Jinhui; Huang, Xiaoqiang

doi:10.1016/j.jep.2015.06.010

Cited by 269 publications

(175 citation statements)

References 108 publications

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“…(Gan-Cao), and Angelica oil. Ku-Shen is a commonly used TCM, used mainly in combination with other medicinal plants in prescriptions to treat fever, dysentery, jaundice, eczema, asthma, and inflammatory disorders [7]. Recent studies have revealed that the extract of Ku-Shen suppresses both helper T cell 2 (Th2) and tumor necrosis factor-α (TNF-α) associated inflammation in murine asthma models [8].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations

Meng

Jia

et al. 2017

IJMS

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Asthma is a chronic inflammatory disorder of the airway and is characterized by airway remodeling, hyperresponsiveness, and shortness of breath. Modified Kushen Gancao Formula (mKG), derived from traditional Chinese herbal medicines (TCM), has been demonstrated to have good therapeutic effects on experimental allergic asthma. However, its anti-asthma mechanism remains currently unknown. In the present work, metabolomics studies of biochemical changes in the lung tissue and plasma of ovalbumin (OVA)-induced allergic asthma mice with mKG treatment were performed using ultra high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS). Partial least squares-discriminate analysis (PLS−DA) indicated that the metabolic perturbation induced by OVA was reduced after mKG treatment. A total of twenty-four metabolites involved in seven metabolic pathways were identified as potential biomarkers in the development of allergic asthma. Among them, myristic acid (L3 or P2), sphinganine (L6 or P4), and lysoPC(15:0) (L12 or P16) were detected both in lung tissue and plasma. Additionally, L-acetylcarnitine (L1), thromboxane B2 (L2), 10-HDoHE (L10), and 5-HETE (L11) were first reported to be potential biomarkers associated with allergic asthma. The treatment of mKG mediated all of those potential biomarkers except lysoPC(15:0) (P16). The anti-asthma mechanism of mKG can be achieved through the comprehensive regulation of multiple perturbed biomarkers and metabolic pathways.

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Section: Introductionmentioning

confidence: 99%

The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations

Meng

Jia

et al. 2017

IJMS

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“…Sophora flavescens , the dried root of S. flavescens Aiton, has been used widely as an herbal remedy in traditional Chinese medicine for various diseases including fever, dysentery, jaundice, abscesses, carbuncles, enteritis, leucorrhoea, pyogenic infections, scabies, and solid tumours (He, Fang, Huang, Wang, & Huang, ; K. Y. Lee, Cha, Choi, & Cha, ). The primary chemical components of S. flavescens include alkaloids (3.3%), flavonoids (1.5%), alkylxanthones, quinones, triterpene glycosides, fatty acids, and essential oils (H. F. Zhang et al, ).…”

Section: Introductionmentioning

confidence: 99%

Effects of alkaloids from Sophora flavescens on osteoblasts infected with Staphylococcus aureus and osteoclasts

Wang¹,

Zheng

Huang³

et al. 2018

Phytotherapy Research

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Chronic osteomyelitis is primarily caused by infection with Staphylococcus aureus (S. aureus). Antibiotics are commonly administered; however, it is a challenge to promote bone healing. The aim of this study was to investigate the in vitro effects of alkaloids from the herbal remedy Sophora flavescens (ASF) on rat calvarial osteoblasts (ROBs) infected with S. aureus and healthy osteoclasts. Cell proliferation and alkaline phosphatase, interleukin-6, and tumour necrosis factor-α activity was measured in infected ROBs; tartrate-resistant acid phosphatase was evaluated in osteoclasts via enzyme-linked immunosorbent assay. The mRNA and protein expression levels of bone morphogenetic protein 2, runt-related transcription factor 2, osteoprotegerin, and receptor activator of nuclear factor kappa-B ligand were assessed in infected ROBs through reverse transcription-polymerase chain reaction and western blotting analysis, respectively. Results indicated that ASF increased the viability of uninfected ROBs and infected ROBs treated with vancomycin via regulation of bone morphogenetic protein 2, runt-related transcription factor, osteoprotegerin, and receptor activator of nuclear factor kappa-B ligand mRNA and protein expression levels. In addition, the secretion of the inflammatory factor tumour necrosis factor-α was decreased and alkaline phosphatase activity was increased, inhibiting the viability of osteoclasts and tartrate-resistant acid phosphatase activity. Therefore, the herbal remedy ASF has potential as a new treatment for chronic osteomyelitis.

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“…Ju et al [13] demonstrated that Xanthium sibiricum has an anti-inflammatory property in LPS-stimulated RAW 264.7 macrophages, and the activity is exerted by the regulation of NF- κ B and STAT3 signaling pathways. Recent studies indicated that a minimum of 50 pure compounds and crude extracts from Sophora flavescens possess wide-ranging antitumor, antimicrobial, and anti-inflammatory pharmacological abilities [14]. Other studies have reported that IL-33 is involved in the inflammatory response of AD [6, 15].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Anti‐Inflammatory Activities of Qingre‐Qushi Recipe (QRQS) against Atopic Dermatitis: Potential Mechanism of Inhibition of IL‐33/ST2 Signal Transduction

Chen

Ding

Yang

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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To evaluate the anti-inflammatory activities of QRQS against AD and the inhibitory molecular mechanisms of IL-33/ST2 signal transduction, BALB/c mice were divided into six groups (normal control, OVA control, low-dose of QRQS, middle-dose of QRQS, high-dose of QRQS, and cetirizine) and epicutaneously exposed to ovalbumin or PBS for 3 weeks and treated with QRQS for 2 weeks. Skin biopsies and blood samples were obtained for histological study, antibody analysis, and RNA isolation. HaCaT cells, stimulated by TNF-α and IFN-γ, were treated with QRQS to evaluate mRNA and protein expression by RT-PCR and ELISA. QRQS decreased both epidermal and dermal thickness, alleviated dermatitis, and reduced IL-33 and ST2 positive cell numbers. The concentration of specific IgE, IgG, IgG1, and IgG2a antibodies in serum and the expression of IL-33, ST2, IL-1RAcP, IL-4, and IL-13 mRNA in the skin were suppressed. No significant difference exists in TNF-α or IFN-γ. QRQS decreased IL-33 mRNA and protein secretion in HaCaT cells exposed to TNF-α and IFN-γ in a time- and concentration-dependent manner. QRQS regulates related molecule expression of ovalbumin-induced dermatitis involved in the IL-33/ST2 signaling axis in the treatment of acute AD.

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Sophora flavescens Ait.: Traditional usage, phytochemistry and pharmacology of an important traditional Chinese medicine

Cited by 269 publications

References 108 publications

The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations

The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations

Effects of alkaloids from Sophora flavescens on osteoblasts infected with Staphylococcus aureus and osteoclasts

Evaluation of Anti‐Inflammatory Activities of Qingre‐Qushi Recipe (QRQS) against Atopic Dermatitis: Potential Mechanism of Inhibition of IL‐33/ST2 Signal Transduction

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