Sophoraflavanone G from Sophora flavescens Ameliorates Allergic Airway Inflammation by Suppressing Th2 Response and Oxidative Stress in a Murine Asthma Model

Abstract

Sophoraflavanone G (SG), isolated from Sophora flavescens, has anti-inflammatory and anti-tumor bioactive properties. We previously showed that SG promotes apoptosis in human breast cancer cells and leukemia cells and reduces the inflammatory response in lipopolysaccharide-stimulated macrophages. We investigated whether SG attenuates airway hyper-responsiveness (AHR) and airway inflammation in asthmatic mice. We also assessed its effects on the anti-inflammatory response in human tracheal epithelial cells. Female BALB/c mice were sensitized with ovalbumin, and asthmatic mice were treated with SG by intraperitoneal injection. We also exposed human bronchial epithelial BEAS-2B cells to different concentrations of SG to evaluate its effects on inflammatory cytokine levels. SG treatment significantly reduced AHR, eosinophil infiltration, goblet cell hyperplasia, and airway inflammation in the lungs of asthmatic mice. In the lungs of ovalbumin-sensitized mice, SG significantly promoted superoxide dismutase and glutathione expression and attenuated malondialdehyde levels. SG also suppressed levels of Th2 cytokines and chemokines in lung and bronchoalveolar lavage samples. In addition, we confirmed that SG decreased pro-inflammatory cytokine, chemokine, and eotaxin expression in inflammatory BEAS-2B cells. Taken together, our data demonstrate that SG shows potential as an immunomodulator that can improve asthma symptoms by decreasing airway-inflammation-related oxidative stress.

Anti-Inflammatory Effects of the LK5 Herbal Complex on LPS- and IL-4/IL-13-Stimulated HaCaT Cells and a DNCB-Induced Animal Model of Atopic Dermatitis in BALB/c Mice

“…Similarly, S . flavescens relieved scratching behavior in serotonin-induced itching in mice [ 60 , 61 ]. D .…”

Anti-Itching and Anti-Inflammatory Effects of Kushenol F via the Inhibition of TSLP Production

“…S. flavescens and its metabolites have been reported to have anti-inflammatory and anti-cancer effects [32,33]. Recently, kushenol F was suggested as an immunomodulator that can improve asthma symptoms by decreasing airway-inflammation-related oxidative stress [34]. However, the effect of kushenol F, isolated from S. flavescens, on AD has not been investigated.…”

Protective Effects of Herba Houttuyniae Aqueous Extract against OVA-Induced Airway Hyperresponsiveness and Inflammation in Asthmatic Mice

“…Terefore, inhibiting and reducing the infammatory response and infammatory cell infltration in the lungs of asthma patients is the main strategy to prevent and relieve asthma attacks. Natural products exhibit the complex chemical backbone and the rich functionalization, making them unique biological activity and unique properties that cannot be replaced as lead compounds in pharmaceutical research [34][35][36][37]. Many antiasthmatic drugs derived from the herbal medicine, such as ephedrine and glycyrrhizic acid, have been used widely in the clinic for prevention and treatment of airway infammation and asthma [38][39][40][41].…”