Sorafenib-loaded hydroxyethyl starch-TG100-115 micelles for the treatment of liver cancer based on synergistic treatment

Li, Guofei; Zhao, Limei

doi:10.1080/10717544.2019.1642418

Cited by 20 publications

(10 citation statements)

References 27 publications

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“…The synthesis of the TC‒mPEG‒PLGA copolymer was accomplished by reacting the carboxyl moiety of mPEG in DDC with the amino group of TC. The TC‒mPEG‒PLGA copolymer was an amphiphilic compound, wherein mPEG acted as hydrophilic groups, while PLGA served as hydrophobic groups ( Li and Zhao, 2019 ). The TC‒mPEG‒PLGA self-assembled into micelles in water on account of the hydrophobic segments segregating from water to form an inner core and the hydrophilic segments orientating outward to contact with water.…”

Section: Resultsmentioning

confidence: 99%

Tetracycline-grafted mPEG-PLGA micelles for bone-targeting and osteoporotic improvement

et al. 2022

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Aim: We aimed to create a nano drug delivery system with tetracycline (TC)-grafted methoxy poly-(ethylene-glycol)‒poly-(D, L-lactic-co-glycolic acid) (mPEG‒PLGA) micelles (TC‒mPEG‒PLGA) with TC and mPEG‒PLGA for potential bone targeting. Prospectively, TC‒mPEG‒PLGA aims to deliver bioactive compounds, such as astragaloside IV (AS), for osteoporotic therapy.Methods: Preparation and evaluation of TC‒mPEG‒PLGA were accomplished via nano-properties, cytotoxicity, uptake by MC3T3-E1 cells, ability of hydroxyapatite targeting and potential bone targeting in vivo, as well as pharmacodynamics in a rat model.Results: The measured particle size of AS-loaded TC‒mPEG‒PLGA micelles was an average of 52.16 ± 2.44 nm, which exhibited a sustained release effect compared to that by free AS. The TC‒mPEG‒PLGA demonstrated low cytotoxicity and was easily taken by MC3T3-E1 cells. Through assaying of bone targeting in vitro and in vivo, we observed that TC‒mPEG‒PLGA could effectively increase AS accumulation in bone. A pharmacodynamics study in mice suggested potentially increased bone mineral density by AS-loaded TC‒mPEG‒PLGA in ovariectomized rats compared to that by free AS.Conclusion: The nano drug delivery system (TC‒mPEG‒PLGA) could target bone in vitro and in vivo, wherein it may be used as a novel delivery method for the enhancement of therapeutic effects of drugs with osteoporotic activity.

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Section: Resultsmentioning

confidence: 99%

Tetracycline-grafted mPEG-PLGA micelles for bone-targeting and osteoporotic improvement

et al. 2022

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“…Phosphoinositide 3-kinase gamma (PI3Kγ) regulates the immunosuppressive properties of TAMs. PI3Kγ inhibitors, such as TG100-115, can induce the expression of MHC-II and proinflammatory cytokines, skewing macrophages to the M1 phenotype while reducing immunosuppressive molecules and inhibiting tumor progression [170].…”

Section: Remodeling M2 Tams To M1 Tamsmentioning

confidence: 99%

Tumor‐associated macrophages in liver cancer: From mechanisms to therapy

Kun

Cai

Zhu

et al. 2022

Cancer Communications

165

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Multidimensional analyses have demonstrated the presence of a unique tumor microenvironment (TME) in liver cancer. Tumor‐associated macrophages (TAMs) are among the most abundant immune cells infiltrating the TME and are present at all stages of liver cancer progression, and targeting TAMs has become one of the most favored immunotherapy strategies. In addition, macrophages and liver cancer cells have distinct origins. At the early stage of liver cancer, macrophages can provide a niche for the maintenance of liver cancer stem cells. In contrast, cancer stem cells (CSCs) or poorly differentiated tumor cells are key factors modulating macrophage activation. In the present review, we first propose the origin connection between precursor macrophages and liver cancer cells. Macrophages undergo dynamic phenotypic transition during carcinogenesis. In this course of such transition, it is critical to determine the appropriate timing for therapy and block specific markers to suppress pro‐tumoral TAMs. The present review provides a more detailed discussion of transition trends of such surface markers than previous reviews. Complex crosstalk occurs between TAMs and liver cancer cells. TAMs play indispensable roles in tumor progression, angiogenesis, and autophagy due to their heterogeneity and robust plasticity. In addition, macrophages in the TME interact with other immune cells by directing cell‐to‐cell contact or secreting various effector molecules. Similarly, tumor cells combined with other immune cells can drive macrophage recruitment and polarization. Despite the latest achievements and the advancements in treatment strategies following TAMs studies, comprehensive discussions on the communication between macrophages and cancer cells or immune cells in liver cancer are currently lacking. In this review, we discussed the interactions between TAMs and liver cancer cells (from cell origin to maturation), the latest therapeutic strategies (including chimeric antigen receptor macrophages), and critical clinical trials for hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA) to provide a rationale for further clinical investigation of TAMs as a potential target for treating patients with liver cancer.

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“…After 95 h, cumulative Cur release has higher at pH = 5.5 (23%) than at pH = 7.4 (8%). In a similar study, PEG 5000 and TG100-115, which is an exclusive PI3Kc inhibitor, were conjugated on hydroxyethyl starch in order to obtain sorafenid-loaded micelles by a dialysis method [ 97 ]. The drug release was investigated as a function of pH (5.5, 6.8, and 7.4), and it appeared that the higher release rate was observed at low pH value.…”

Section: Micellar Drug Delivery Systems Based On Polysaccharidesmentioning

confidence: 99%

Micellar Drug Delivery Systems Based on Natural Biopolymers

Atanase

2021

Polymers

160

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The broad diversity of structures and the presence of numerous functional groups available for chemical modifications represent an enormous advantage for the development of safe, non-toxic, and cost-effective micellar drug delivery systems (DDS) based on natural biopolymers, such as polysaccharides, proteins, and peptides. Different drug-loading methods are used for the preparation of these micellar systems, but it appeared that dialysis is generally recommended, as it avoids the formation of large micellar aggregates. Moreover, the preparation method has an important influence on micellar size, morphology, and drug loading efficiency. The small size allows the passive accumulation of these micellar systems via the permeability and retention effect. Natural biopolymer-based micellar DDS are high-value biomaterials characterized by good compatibility, biodegradability, long blood circulation time, non-toxicity, non-immunogenicity, and high drug loading, and they are biodegraded to non-toxic products that are easily assimilated by the human body. Even if some recent studies reported better antitumoral effects for the micellar DDS based on polysaccharides than for commercial formulations, their clinical use is not yet generalized. This review is focused on the studies from the last decade concerning the preparation as well as the colloidal and biological characterization of micellar DDS based on natural biopolymers.

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Sorafenib-loaded hydroxyethyl starch-TG100-115 micelles for the treatment of liver cancer based on synergistic treatment

Cited by 20 publications

References 27 publications

Tetracycline-grafted mPEG-PLGA micelles for bone-targeting and osteoporotic improvement

Tetracycline-grafted mPEG-PLGA micelles for bone-targeting and osteoporotic improvement

Tumor‐associated macrophages in liver cancer: From mechanisms to therapy

Micellar Drug Delivery Systems Based on Natural Biopolymers

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