Sorbitol in the accessory glands of the diabetic male rat

Abstract

Diabetes was induced in rats by i.v. injection of streptozotocin (60 mg/kg body weight). Diabetes was accompanied by infertility and atrophy of the male accessory glands. Blood glucose rose above 500 mg% (post-prandial) and blood testosterone decreased to 14% of the level found in normoglycemic rats. Diabetes was followed by increased levels of sorbitol in the male accessory glands, prostate, seminal vesicle and coagulating gland, and in the eyes and sciatic nerves. Insulin treatment of the diabetic rats prevented sorbitol accumulation in the above tissues. AY-22, 284, and inhibitor of aldose reductase given in the food (1 g/kg body weight/day) for 3 weeks, did not prevent sorbitol accumulation in the organs mentioned. The changes in sorbitol metabolism in the diabetic rat and their possible involvement in male fertility are discussed.

Localization and Physiological Implication of Aldose Reductase and Sorbitol Dehydrogenase in Reproductive Tracts and Spermatozoa of Male Rats

“…Under hyperglycemic conditions, dysfunction occurs in the male reproductive tract, including testis (Sexton and Jarow, 1997), and abnormal sorbitol accumulation has been demonstrated in accessory glands (Paz et al, 1980). A stage-specific increase in apoptotic cell death of germ cells is observed in seminiferous tubules in animals with diabetes (Sainio-Pollanen et al, 1997).…”