Sorbitol-Plasticized and Neutralized Chitosan Membranes as Skin Substitutes

Abstract

Chitosan is soluble in diluted acid solutions and can easily form films by casting. However, residual acid neutralization should be performed for biomedical applications what may compromise physical and mechanical properties of the films. Thus, plasticizers can be added to improve these properties. The aim of this study was to characterize morphological, barrier and mechanical properties, besides evaluate the in vitro cytotoxicity of sorbitol-plasticized and NaOH-Na 2 CO 3 neutralized chitosan membranes for skin substitute application. Scanning electron microscopy, X-ray diffraction, water vapor permeability and mechanical tests were carried out to characterize the obtained membranes. Moreover, Vero cells were used for in vitro cytotoxicity evaluation. In this paper, we report a non-cytotoxic sorbitol-plasticized chitosan membrane with desirable properties for skin substitution, such as flexibility, water vapor permeability and high percentage of elongation.

Chitosan Associated with the Extract of Unripe Banana Peel for Potential Wound Dressing Application

“…The choice of dressing depends on several factors, such as the cause, size, depth, location, and degree of exudation and level of contamination of the wound [6]. An ideal dressing should protect the wound from further trauma and against contamination, ensure a moist environment by absorbing or remove excess exudate, and be flexible, biodegradable, and cost-effective [6,8]. Currently, there are hundreds of products, devices, and dressing materials on the market to aid in wound management.…”

“…Chitosan based dressings have mostly been investigated to due to chitosan's favorable properties suitable for wound healing, such as intrinsic antimicrobial properties and hemostatic activity, besides being biodegradable, biocompatible, bioadherent, and nontoxic [4,8,9]. Chitosan is derived from chitin, which can be found as the primary structural polymer in the exoskeleton of crustacean [9].…”

Heterogeneous method of chitosan film preparation: Effect of multifunctional acid on film properties

“…Therefore, even if the thickness of neutralized films matched that of neat films, their WVP values would likely exceed the average value of 10.70 × 10 −11 g (m −1 ·s −1 ·Pa −1 ). Increase in WVP of chitosan films after neutralization has previously been reported, whether neutralized with a similar procedure as the one used here, or by spraying the film with NaOH …”

Biomateriais de quitosana/gelatina com resina de jatobá: influência do grau de acetilação da quitosana e da inclusão da resina

“…Geralmente a quitina é obtida a partir de resíduos da indústria pesqueira, e portanto, seu uso pode ainda ser considerado uma forma de redução do impacto ambiental causado por seu acúmulo. 16,18 Para o mercado mundial de quitosana, que em 2015 se estima ter movimentado 2,8 bilhões de dólares, se prevê um cenário favorável de crescimento nos faturamentos. A empresa de pesquisa de mercado e consultoria de gestão Esta previsão de crescimento no faturamento do mercado mundial de quitosana de quase 300% em apenas 9 anos está relacionado, sobretudo, às expectativas de aumento nos rendimentos com a aplicação de quitosana na área de tratamento de águas, em virtude da rápida industrialização e urbanização das nações do BRIC (Brasil, Rússia, Índia e China), e nas áreas biomédica e farmacêutica, para as quais também se projetam grandes expansões de mercado.…”

“…Também é encontrada em paredes celulares de fungos e em moluscos, chegando ao posto de segundo polissacarídeo mais abundante na natureza, menos abundante apenas que a celulose. 18 Justamente por ser um polímero de origem natural, suas características e, consequentemente, de seu derivado quitosana, são influenciadas por sua fonte, sazonalidade e local de coleta.…”