Sorting nexin Mdm1/SNX14 regulates nucleolar dynamics at the NVJ after TORC1 inactivation

Sharmin, Tasnuva; Takuma, Tsuneyuki; Morshed, Shamsul; Ushimaru, Takashi

doi:10.1016/j.bbrc.2021.03.033

Cited by 5 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings suggest Mdm1 and Nvj2 play a specific role in neutral lipid synthesis and LD dynamics. Different studies have shown a role of NVJ proteins in regulating nucleolar dynamics [44,45]. Furthermore, it is noteworthy that Cvm1, a yeast protein that forms NVJ and vCLAMP, is required for sphingolipid homeostasis [46].…”

Section: Discussionmentioning

confidence: 99%

Vacuole membrane contact sites regulate liquid‐ordered domain formation during glucose starvation

et al. 2023

View full text Add to dashboard Cite

Liquid‐ordered (Lo) membrane domains have been proposed to play important roles in a wide variety of biological processes, such as protein sorting and cell signaling. However, the mechanisms by which they are formed and maintained remain poorly understood. Lo domains are formed in the vacuolar membrane of yeast in response to glucose starvation. Here, we show that the deletion of proteins that localize to vacuole membrane contact sites (MCSs) caused a marked decrease in the number of cells with Lo domains. In addition to Lo domain formation, autophagy is induced upon glucose starvation. However, the deletion of core autophagy proteins did not inhibit Lo domain formation. Thus, we propose that vacuolar Lo domain formation during glucose restriction is regulated by MCSs but not by autophagy.

show abstract

Section: Discussionmentioning

confidence: 99%

Vacuole membrane contact sites regulate liquid‐ordered domain formation during glucose starvation

et al. 2023

View full text Add to dashboard Cite

show abstract

“…It is likely that Mdm1 participates in FA activation to support LD biogenesis. More recently, it was shown that Mdm1 prompts nucleophagic degradation of nucleolar proteins at the NVJ when TORC1 is inactive, but it was unnecessary for nucleophagic flux [227]. Like Pex30, Mdm1 and many other tethering proteins bring different organelles in close proximity using different lipid-binding specificities, thus forming individual LD sub-populations at distinct MCSs.…”

Section: Mdm1/sortin Nexin 14mentioning

confidence: 99%

Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implications

Rakotonirina-Ricquebourg

Costa

Teixeira

2022

Progress in Lipid Research

View full text Add to dashboard Cite

The yeast VAPs Scs2 and Scs22 are required for NVJ integrity and micronucleophagy

Manik,

Tasnin,

Takuma

et al. 2024

Biochemical and Biophysical Research Communications

View full text Add to dashboard Cite

Sorting nexin Mdm1/SNX14 regulates nucleolar dynamics at the NVJ after TORC1 inactivation

Cited by 5 publications

References 30 publications

Vacuole membrane contact sites regulate liquid‐ordered domain formation during glucose starvation

Vacuole membrane contact sites regulate liquid‐ordered domain formation during glucose starvation

Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implications

The yeast VAPs Scs2 and Scs22 are required for NVJ integrity and micronucleophagy

Contact Info

Product

Resources

About