Sound localization: effects of unilateral lesions in central auditory system.

Jenkins, William M.; Masterton, R.B.

doi:10.1152/jn.1982.47.6.987

Cited by 325 publications

(209 citation statements)

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“…These findings are further corroborated by results obtained in animal models [14,18]. However, unlike in animal models [53], the dominant role of the righthemispheric auditory areas in sound localization in humans has been highlighted in measurements of the human brain [17,21,32,33,54], and in studies on patients with righthemispheric lesions [8,9,53].…”

Section: Introductionsupporting

confidence: 67%

Spatial processing in human auditory cortex: The effects of 3D, ITD, and ILD stimulation techniques

Palomäki

Tiitinen

Mäkinen

et al. 2005

Cognitive Brain Research

100

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Here, the perception of auditory spatial information as indexed by behavioral measures is linked to brain dynamics as reflected by the N1m response recorded with whole-head magnetoencephalography (MEG). Broadband noise stimuli with realistic spatial cues corresponding to eight direction angles in the horizontal plane were constructed via custom-made, individualized binaural recordings (BAR) and generic head-related transfer functions (HRTF). For comparison purposes, stimuli with impoverished acoustical cues were created via interaural time and level differences (ITDs and ILDs) and their combinations. MEG recordings in ten subjects revealed that the amplitude and the latency of the N1m exhibits directional tuning to sound location, with the amplitude of the right-hemispheric N1m being particularly sensitive to the amount of spatial cues in the stimuli. The BAR, HRTF, and combined ITD + ILD stimuli resulted both in a larger dynamic range and in a more systematic distribution of the N1m amplitude across stimulus angle than did the ITD or ILD stimuli alone. Further, the righthemispheric source loci of the N1m responses for the BAR and HRTF stimuli were anterior to those for the ITD and ILD stimuli. In behavioral tests, we measured the ability of the subjects to localize BAR and HRTF stimuli in terms of azimuthal error and front-back confusions. We found that behavioral performance correlated positively with the amplitude of the N1m. Thus, the activity taking place already in the auditory cortex predicts behavioral sound detection of spatial stimuli, and the amount of spatial cues embedded in the signal are reflected in the activity of this brain area. D

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Section: Introductionsupporting

confidence: 67%

Spatial processing in human auditory cortex: The effects of 3D, ITD, and ILD stimulation techniques

Palomäki

Tiitinen

Mäkinen

et al. 2005

Cognitive Brain Research

100

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“…In adult cats and ferrets, unilateral destruction of the inferior colliculus severely disrupts sound localization with the effects most apparent in the spatial field contralateral to the side of the lesion (Jenkins and Masterton, 1982;Kelly and Kavanagh, 1994). Comparable data are not available for adult rats, but one might expect severe deficits after unilateral IC lesions considering the deficits in sound localization produced by unilateral damage of binaural structures with direct projections to the IC, viz., the superior olivary complex and the dorsal nucleus of the lateral lemniscus (Ito et al, 1996;Kelly et al, 1996;van Adel and Kelly, 1998).…”

Section: Methodsmentioning

confidence: 99%

Anatomical plasticity in brainstem auditory nuclei following unilateral ablation of the inferior colliculus in neonatal rats

et al. 2008

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Anatomical plasticity of projections from brainstem auditory structures to the inferior colliculus (IC) was examined in albino rats to determine the effects of unilateral destruction of the IC during early development. The IC in the right hemisphere was destroyed by aspiration on postnatal day 3. Upon reaching adulthood, the rats were examined by retrograde tract tracing methods with fluoro-gold (FG) and [

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“…Although lesions that include auditory cortex can impair sound localization in both animals and humans (Sanchez-Longo and Forster, 1958;Jenkins and Masterton, 1982;Thompson and Cortez, 1983;Hefner and Heffner, 1986;Zatorre and Penhune, 2001;Smith et al, 2004;King et al, 2007), human neuroimaging studies have had mixed success at identifying differential patterns of activation as a function of sound location. For monaural sounds, activation is stronger in the contralateral than in the ipsilateral primary auditory cortex (Woldorff et al, 1999;Petkov et al, 2004;Krumbholz et al, 2005a), but no contralateral preference has been found for more realistic binaural stimuli (Woldorff et al, 1999;Brunetti et al, 2005;Krumbholz et al, 2005b;Zimmer and Macaluso, 2005;Zimmer et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

A Rate Code for Sound Azimuth in Monkey Auditory Cortex: Implications for Human Neuroimaging Studies

Werner-Reiss

2008

J. Neurosci.

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Is sound location represented in the auditory cortex of humans and monkeys? Human neuroimaging experiments have had only mixed success at demonstrating sound location sensitivity in primary auditory cortex. This is in apparent conflict with studies in monkeys and other animals, in which single-unit recording studies have found stronger evidence for spatial sensitivity. Does this apparent discrepancy reflect a difference between humans and animals, or does it reflect differences in the sensitivity of the methods used for assessing the representation of sound location? The sensitivity of imaging methods such as functional magnetic resonance imaging depends on the following two key aspects of the underlying neuronal population: (1) what kind of spatial sensitivity individual neurons exhibit and (2) whether neurons with similar response preferences are clustered within the brain.To address this question, we conducted a single-unit recording study in monkeys. We investigated the nature of spatial sensitivity in individual auditory cortical neurons to determine whether they have receptive fields (place code) or monotonic (rate code) sensitivity to sound azimuth. Second, we tested how strongly the population of neurons favors contralateral locations. We report here that the majority of neurons show predominantly monotonic azimuthal sensitivity, forming a rate code for sound azimuth, but that at the population level the degree of contralaterality is modest. This suggests that the weakness of the evidence for spatial sensitivity in human neuroimaging studies of auditory cortex may be attributable to limited lateralization at the population level, despite what may be considerable spatial sensitivity in individual neurons.

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Sound localization: effects of unilateral lesions in central auditory system.

Cited by 325 publications

References 0 publications

Spatial processing in human auditory cortex: The effects of 3D, ITD, and ILD stimulation techniques

Spatial processing in human auditory cortex: The effects of 3D, ITD, and ILD stimulation techniques

Anatomical plasticity in brainstem auditory nuclei following unilateral ablation of the inferior colliculus in neonatal rats

A Rate Code for Sound Azimuth in Monkey Auditory Cortex: Implications for Human Neuroimaging Studies

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