Ethiopia has been reflecting the environmental sustainability interests. However, questions have been raised regarding its effectiveness. Thus, this paper addresses one of the environmental sustainability issues specifically Borkena river pollution. Furthermore, it addresses the causes and effects of Borkena river pollution on environmental sustainability. By employing an exploratory approach, formative analysis and conclusions are made. As a result, Borkena River is found highly depleted due to wastes from households, institutions and industries. Mountainous farming, lack of environmental protection measures, alien weed, informal settlement, poor waste management system and inappropriate utilization of river resources are the major causes of Borkena River pollution. As a result, the river pollution affects the environmental sustainability in the area of natural resources, biodiversity and human ecology at large. Thus, the research outlines the following directions to be implemented for protecting Borkena River from pollution and maintaining environmental sustainability. Among these, (1) revisiting the rivers depletion and the extent of environmental pollution on a broader scale, (2) policy revision should be considered in responding river pollution and environmental sustainability measures, (3) expanding best environmental protection practices in Borkena river side, and (4) reconsidering river rehabilitation through realizing its economic benefits for the local community.