Source localization of middle latency auditory evoked magnetic fields

Yamada, Takashi; Ueno, S.; Iramina, Keiji; Masuda, Kouji

doi:10.1016/0006-8993(95)01075-0

Cited by 57 publications

(30 citation statements)

References 17 publications

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“…In contrast P50 amplitudes were larger in MCI than controls at both stimulus rates. The differences between the recovery functions of P50 and N100 in MCI may be due to different generator sites in auditory cortex (Liegeois-Chauvel et al, 1994;Onitsuka et al, 2000;Reite et al, 1988;Yoshiura et al, 1995) and/or to changes in connectivity specific to the N100 generator (Chao and Knight, 1998). There were no significant group effects for the P200 component, a result consistent with previous studies (Golob et al, 2001(Golob et al, , 2002.…”

Section: Rate Effects Of Long-latency Evoked Potentialssupporting

confidence: 88%

“…P50 amplitude increases in MCI are not specific to the use of an auditory discrimination task as P50 amplitudes are also increased relative to controls when passively listening to tones (Golob et al, 2001). P50 is thought to reflect neural activity in primary/secondary auditory cortex (Liegeois-Chauvel et al, 1994;Reite et al, 1988;Yoshiura et al, 1995) and the definition of large P50 amplitudes in MCI compared to controls may reflect group differences at auditory sensory cortex. It is well known that the amplitude of sensory cortical potentials is affected by rate of stimulation (Picton et al, 1974).…”

Section: Introductionmentioning

confidence: 98%

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Auditory brain-stem, middle- and long-latency evoked potentials in mild cognitive impairment

Irimajiri

Golob

Starr

2005

Clinical Neurophysiology

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Objective: Mild cognitive impairment (MCI) is a selective episodic memory deficit in the elderly with a high risk of Alzheimer's disease. The amplitudes of a long-latency auditory evoked potential (P50) are larger in MCI compared to age-matched controls. We tested whether increased P50 amplitudes in MCI were accompanied by changes of middle-latency potentials occurring around 50 ms and/or auditory brainstem potentials. Methods: Auditory evoked potentials were recorded from age-matched controls (nZ16) and MCI (nZ17) in a passive listening paradigm at two stimulus presentation rates (2/s, 1/1.5 s). A subset of subjects also received stimuli at a rate of 1/3 s. Results: Relative to controls, MCI subjects had larger long-latency P50 amplitudes at all stimulus rates. Significant group differences in N100 amplitude were dependent on stimulus rate. Amplitudes of the middle-latency components (Pa, Nb, P1 peaking at approximately 30, 40, and 50 ms, respectively) did not differ between groups, but a slow wave between 30 and 49 ms on which the middle-latency components arose was significantly increased in MCI. ABR Wave V latency and amplitude did not differ significantly between groups. Conclusions: The increase of long-latency P50 amplitudes in MCI reflects changes of a middle-latency slow wave, but not of transient middle-latency components. There was no evidence of group difference at the brain-stem level. Significance: Increased slow wave occurring as early as 50 ms may reflect neurophysiological consequences of neuropathology in MCI.

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Section: Rate Effects Of Long-latency Evoked Potentialssupporting

confidence: 88%

Section: Introductionmentioning

confidence: 98%

Auditory brain-stem, middle- and long-latency evoked potentials in mild cognitive impairment

Irimajiri

Golob

Starr

2005

Clinical Neurophysiology

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“…The P50 component has been shown to be generated by neurons located in primary/secondary auditory cortex (Reite et al, 1988;Woldorff et al, 1993;Liegeois-Chauvel et al, 1994;Yoshiura et al, 1995). Although pathological changes may be present within auditory cortex in MCI, neuropathological studies of Alzheimer's disease have shown that primary and secondary auditory cortices are typically spared until late in the disease process (Arnold et al, 1991).…”

Section: P50 and P300 Abnormalities In Mild Cognitive Impairmentmentioning

confidence: 99%

Auditory event-related potentials during target detection are abnormal in mild cognitive impairment

Golob

Johnson

Starr

2002

Clinical Neurophysiology

135

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Objective: To define brain activity and behavioral changes in mild cognitive impairment (MCI), an isolated memory deficit in the elderly that is a major risk factor for Alzheimer's disease.Methods: Brain potentials and reaction time were examined in elderly controls (n ¼ 12) and MCI (n ¼ 15) using a target detection paradigm. Subjects listened to a sequence of tones and responded to high-pitched target tones (P ¼ 0:20) that were randomly mixed with low-pitched tones (P ¼ 0:80

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“…We succeeded in detecting auditory brainstem magnetic fields , middle latency auditory-evoked magnetic fields [Yoshiura et al, 1994[Yoshiura et al, , 1995, and extremely low frequency magnetic fields associated with short-term memory processes [Yoshida et al, 1995;Nakagawa et al, 1996Nakagawa et al, , 2004Nakagawa and Ueno, 1999;Gjini et al, 2005].…”

Section: Magnetoencephalography (Meg)mentioning

confidence: 99%

Studies on magnetism and bioelectromagnetics for 45 years: From magnetic analog memory to human brain stimulation and imaging

Ueno

2011

Bioelectromagnetics

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Forty-five years of studies on magnetism and bioelectromagnetics, in our laboratory, are presented. This article is prepared for the d'Arsonval Award Lecture. After a short introduction of our early work on magnetic analog memory, we review and discuss the following topics: (1) Magnetic nerve stimulation and localized transcranial magnetic stimulation (TMS) of the human brain by figure-eight coils; (2) Measurements of weak magnetic fields generated from the brain by superconducting quantum interference device (SQUID) systems, called magnetoencephalography (MEG), and its application in functional brain studies; (3) New methods of magnetic resonance imaging (MRI) for the imaging of impedance of the brain, called impedance MRI, and the imaging of neuronal current activities in the brain, called current MRI; (4) Cancer therapy and other medical treatments by pulsed magnetic fields; (5) Effects of static magnetic fields and magnetic control of cell orientation and cell growth; and (6) Effects of radio frequency magnetic fields and control of iron ion release and uptake from and into ferritins, iron cage proteins. These bioelectromagnetic studies have opened new horizons in magnetism and medicine, in particular for brain research and treatment of ailments such as depression, Parkinson's, and Alzheimer's diseases.

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Source localization of middle latency auditory evoked magnetic fields

Cited by 57 publications

References 17 publications

Auditory brain-stem, middle- and long-latency evoked potentials in mild cognitive impairment

Auditory brain-stem, middle- and long-latency evoked potentials in mild cognitive impairment

Auditory event-related potentials during target detection are abnormal in mild cognitive impairment

Studies on magnetism and bioelectromagnetics for 45 years: From magnetic analog memory to human brain stimulation and imaging

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