Source of Copper May Have Regressive Effects on Serum Cholesterol and Urea Nitrogen Among Male Fattening Lambs

Abstract

An experiment was conducted to determine the effect of dietary copper (Cu) on mineral profile, hematological parameters, and lipid metabolism in lambs. Eighteen Zandi male lambs (approximately 3 months of age; 17.53±1.6 kg of body weight) were housed in individual pens and were assigned randomly to one of three treatments. Treatments consisted of (1) control (no supplemental Cu), (2) 10 mg Cu/kg dry matter (DM) from copper sulfate (CuS), and (3) 10 mg Cu/kg DM from Cu proteinate (CuP). The Cu concentration was 8.2 mg/kg DM in the basal diet. Blood was sampled from the jugular vein at the beginning of the study (enrollment, before feeding Cu supplement) and at days 25, 50, and 70 of experiment. The amounts of total serum glucose, urea nitrogen, calcium, phosphorus, iron, copper, zinc, and lipids and hematological parameters were measured. Average daily gain and feed efficiency were improved (P<0.05) with Cu supplementation and were better for the lambs fed diet supplemented with CuP. The concentrations of serum Ca, P, and Zn were not affected by source of Cu in the diet. However, Fe concentration was lower (P<0.01) in the Cu-supplemented groups. Experimental treatment had no significant effects on the hematological parameters. The serum glucose concentration was not affected by treatments. However, the urea nitrogen concentrations were significantly affected (P<0.05) by added Cu and was lower for CuP group as compared to the lambs in the CuS and control groups. Addition of Cu had no influence (P>0.05) on the serum triglyceride concentration, but lambs fed with CuP supplement had lower (P<0.05) serum cholesterol than the CuS and control animals. These results indicated that CuP supplemented at 10 mg/kg DM improved gain and enhanced the efficiency of nitrogen in male lambs.

Productive Peformance, Nutrients Digestibility and Some Serum Metabolic Indices as Affected by Dieatary Supplementation of Copper and Zinc in Egyptian Buffalo Calves

“…In the current study, although serum glucose concentrations were not significantly different among calves fed Cu, Zn and Cu plus Zn supplemented rations vs. control (Table 4), their levels were maintained within the normal physiological ranges reviewed in bovine (Hussein et al, 2013). The results are in keeping with some studies working on cattle (Sobhanirad and Naserian, 2012) and sheep (Hosienpour et al, 2014 andJafarpour et al, 2015). Data illustrated in Table (4) showed a decrease (P<0.05) in serum cholesterol concentrations concomitant with an increase in serum HDL with no significant changes in serum triglycerides for calves fed Cu-supplemented ration vs. control.…”

“…The decrease in serum cholesterol concentrations with dietary supplemental Cu was also detected in young Holstein bulls (Fagari-Nobijari et al, 2013). Similar responses of these lipid parameters were also noticed with dietary supplemental Cu in male fattening lambs diet (Hosienpour et al, 2014) and finishing steers (Engle et al, 2000). These results may be emphasized that dietary supplemental Cu, at physiological concentrations, can alter plasma lipid metabolism in ruminants (Engle, 2011).…”

“…Also, the tendency of Cu to improve TDNI, FCR, FC-DCP and FC-TDN may be interacted in the positive effect of supplemental Cu on ADG. Similar effects of supplemental Cu on ADG were detected in dairy calves (Heiderpour et al, 2008), bulls (Netto et al, 2014) and male lambs (Hosienpour et al, 2014). In young Holstein bulls, supplemental Cu (30 mg/kg DM) improved their growth performance and decreases the prevalence of lameness (Fagari-Nobijari et al, 2013).…”

Effect of Organic or Inorganic Mineral Premix in the Diet on Laying Performance of Aged Laying Hens and Eggshell Quality

“…The leukocyte count has been used as a measure of immune function in birds [ 32 ]. Hosienpour et al [ 33 ] reported that the supplementation of organic minerals did not affect the hematological parameters of lamb. In contrast, previous research reported that supplementation of organic trace minerals increased RBV parameters and hematological response in animals [ 34 , 35 ].…”

Effects of inorganic and nano copper supplementation on haematology, blood biochemical and plasma mineral status in growing cattle

“…Cu level was observed maximum in 10 ppm nano Cu supplemented heifers followed by nanoCu 5 and inCu 10 groups. Similarly, increase in plasma Cu concentration in goats (Mondal et al 2017, Shen et al 2020, lambs (Hosienpour et al 2014) and growing heifers (Vaswani et al 2018) was reported on supplementation of Cu (irrespective of organic or inorganic form). On the contrary, a study on dairy cows reported no effect on plasma Cu levels by supplementation of different Cu sources (Sinclair et al 2013).…”