Source of Subretinal Fluid on the Basis of Ascorbate Analyses

Heuven, W. A. J. Van; Lam, Kwok-Wai; Ray, G. Stewart

doi:10.1001/archopht.1982.01030030984017

Cited by 10 publications

(2 citation statements)

References 7 publications

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“…It has been demonstrated that in RD, aqueous bulk flow in the anterior chamber is reduced because of the presence of "misdirected" flow of the aqueous humor, which is diverted from the posterior chamber toward the vitreous cavity, through the retinal hole, and across the retinal pigment epithelium. [20][21][22] It is generally accepted that aqueous proteins exit the eye by aqueous bulk flow. 23,24 Therefore, a decrease in the flow rate consequently leads to an increase in aqueous flare intensity.…”

Section: Discussionmentioning

confidence: 47%

Time Course of Changes in Aqueous Flare Intensity After Vitrectomy for Rhegmatogenous Retinal Detachment

Hoshi¹,

Okamoto²,

Hasegawa³

et al. 2012

Retina

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Section: Discussionmentioning

confidence: 47%

Time Course of Changes in Aqueous Flare Intensity After Vitrectomy for Rhegmatogenous Retinal Detachment

Hoshi¹,

Okamoto²,

Hasegawa³

et al. 2012

Retina

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“…19 Aqueous humour may also contribute to the formation of subretinal fluid, because of a flow of aqueous through the retinal hole. 20 No studies have reported on cGMP levels in normal human aqueous humour. In normal rabbit eyes cGMP levels in aqueous humour were 10 times lower than in vitreous humour.…”

Section: Discussionmentioning

confidence: 99%

Decreased levels of cGMP in vitreous and subretinal fluid from eyes with retinal detachment

Heij

2003

British Journal of Ophthalmology

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Background: Cyclic guanosine monophosphate (cGMP) is produced in different retinal cells, including photoreceptor cells, wherein cGMP mediates photo-transduction. CGMP is degraded by phosphodiesterases (PDE). The aim was to investigate whether retinal detachment alters intraocular cGMP levels in human eyes. Methods: cGMP and PDE were determined in vitreous fluid from 50 eyes with a retinal detachment (group I) and in 20 control samples (group II) of vitreous fluid from eyes without retinal detachment. Group III consisted of subretinal fluid samples from 70 eyes with retinal detachment. Results: cGMP in vitreous fluid from eyes with retinal detachment (6.5 (SD 1.7) nM) was decreased compared to controls (67.1 (10.0) nM) (p,0.0001). In subretinal fluid, the mean level of cGMP was 2.4 (0.2) nM. No PDE could be detected in any of the intraocular fluid samples of patients nor controls. A decrease in the mean level of cGMP in subretinal fluid of eyes with retinal detachment correlated with a longer duration of detachment (r = 20.45, p = 0.007). Conclusions: Retinal detachment was found to be associated with a decrease in vitreous cGMP concentration. In subretinal fluid, a low cGMP level correlated inversely with the duration of the detachment.

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Experimental Retinal Detachment

Pederson¹,

Cantrill²

1984

Arch Ophthalmol

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Source of Subretinal Fluid on the Basis of Ascorbate Analyses

Cited by 10 publications

References 7 publications

Time Course of Changes in Aqueous Flare Intensity After Vitrectomy for Rhegmatogenous Retinal Detachment

Time Course of Changes in Aqueous Flare Intensity After Vitrectomy for Rhegmatogenous Retinal Detachment

Decreased levels of cGMP in vitreous and subretinal fluid from eyes with retinal detachment

Experimental Retinal Detachment

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