Background: Cyanide is among the most harmful substances on Earth and it is harmful to humans and most aquatic life even at low concentrations. Free, total cyanide levels and other physicochemical parameters were determined in fish, cassava, cocoyam, dam and borehole water samples collected from Kenyasi, Ghana. A total of sixteen (16) that the variation in free cyanide levels was significant (p < 0.05) in the fish, cassava, cocoyam, dam and borehole water samples. Moreover, the hazard index results via ingestion and dermal contact with children are >1, including fish ingestion by an adult. This signifies adverse non-carcinogenic risk. The persistent intake of cassava and cocoyam can probably induce adverse health effects. Conclusions: From the results, it can be concluded that fish, cassava and water samples at Dam 4, Dam 7 and BH1 were not safe for consumption since they recorded values higher than the set limits. Therefore, people are advised not to feed on the cassava product, fish and consume water samples located close to Dam 4, Dam 7 and BH1.