Sources of frequency following responses (FFR) in man

Sohmer, Haim; Pratt, H; Kinarti, R

doi:10.1016/0013-4694(77)90282-6

Cited by 141 publications

(76 citation statements)

References 14 publications

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“…7), and thus explain the larger influence on these two dipole solutions. in humans which suggest the IC as the FFR's primary origin (e.g., Sohmer et al, 1977). Our results are also consistent with dipole analyses of the ASSR evoked by modulated tones, which for high modulation rates (comparable to those used here), are generated by brainstem sources (Herdman et al, 2002;Kiren et al, 1994).…”

Section: Source Dipoles Underlying the Scalp-recorded Ffrsupporting

confidence: 92%

“…Together with our new findings, these studies support the growing body of evidence which suggests that onset and sustained portions of the human brainstem response are generated by distinct portions of the auditory system (Worthington and Peters, 1980) and originate from separate neuroanatomical populations along the pathway (e.g., Krizman et al, 2010;Parthasarathy and Bartlett, 2012;Picton et al, 1978;Ross et al, 2002). This proposition is also consist with observations in humans, that ABR wave V is generated primarily by the lateral lemniscus (Møller and Jannetta, 1982) while the FFR arises from the colliculi (Sohmer et al, 1977).…”

Section: Dissociation Between the Onset Abr Response And Sustained Ffrsupporting

confidence: 51%

“…This premise is based primarily on indirect/converging evidence from its response properties: the short latency of the FFR (~6e8 ms) is too early to reflect contribution from cortical generators (Galbraith et al, 2000); the FFR contains phase-locked activity (e.g., >1000 Hz) well beyond the upper limit of phase-locking in cortex (i.e.,~100 Hz) (Aiken and Picton, 2008;Akhoun et al, 2008a;Wallace et al, 2000); and there is a high correspondence between far-field FFRs and near-field intracranial potentials recorded directly from the IC (Smith et al, 1975). More definitive evidence for the FFR's neural generators stems from lesion data which demonstrates that focal ablation of the IC in cats (Davis and Britt, 1984;Smith et al, 1975) and humans (Sohmer et al, 1977) abolishes the scalp-recorded FFR. However, we are aware of no study to date which has attempted to localize the human FFR elicited by speech using noninvasive methodologies and in neurological normal listeners.…”

Section: Introductionmentioning

confidence: 90%

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Multichannel recordings of the human brainstem frequency-following response: Scalp topography, source generators, and distinctions from the transient ABR

2015

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Section: Source Dipoles Underlying the Scalp-recorded Ffrsupporting

confidence: 92%

Section: Dissociation Between the Onset Abr Response And Sustained Ffrsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 90%

See 1 more Smart Citation

Multichannel recordings of the human brainstem frequency-following response: Scalp topography, source generators, and distinctions from the transient ABR

2015

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“…Following this onset response is the sustained FFR that represents a neural population that phase locks to the periodic aspects of the syllable (Worden & Marsh, 1968). This sustained response contains transient peaks synchronized to the fundamental and harmonic frequency components of the stimulus (Wilson & Dobie, 1987;Dobie & Wilson, 1984;Sohmer, Pratt, & Kinarti, 1977). A less commonly discussed attribute of neural response to acoustical stimuli is the offset response.…”

Section: Relationships Between Backward Masking and Speech Perceptionmentioning

confidence: 99%

Auditory Brainstem Correlates of Perceptual Timing Deficits

Johnson

Nicol²,

Zecker

et al. 2007

Journal of Cognitive Neuroscience

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Abstract& Children with language-based learning problems often exhibit pronounced speech perception difficulties. Specifically, these children have increased difficulty separating brief sounds occurring in rapid succession (temporal resolution). The purpose of this study was to better understand the consequences of auditory temporal resolution deficits from the perspective of the neural encoding of speech. The findings provide evidence that sensory processes relevant to cognition take place at much earlier levels than traditionally believed. Thresholds from a psychophysical backward masking task were used to divide children into groups with good and poor temporal resolution. Speech-evoked brainstem responses were analyzed across groups to measure the neural integrity of stimulus-time mechanisms. Results suggest that children with poor temporal resolution do not have an overall neural processing deficit, but rather a deficit specific to the encoding of certain acoustic cues in speech. Speech understanding relies on the ability to attach meaning to rapidly fluctuating changes of both the temporal and spectral information found in consonants and vowels.

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“…There is convincing evidence that the FFR is generated in the auditory brainstem, because cooling the inferior colliculus in cats abolishes the FFR recorded from the scalp, whereas the response is still present caudally at the superior olivary complex (Smith et al, 1975). Also, in patients with lesions in the inferior colliculus, no FFR could be recorded from the scalp (Sohmer et al, 1977). However, whether the human auditory brainstem is able to detect novel auditory stimuli remains to be proved.…”

Section: Introductionmentioning

confidence: 99%

Novelty Detection in the Human Auditory Brainstem

Slabu¹,

Grimm²,

Escera³

2012

J. Neurosci.

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Auditory deviance detection has been associated with a human auditory-evoked potential (AEP), the mismatch negativity, generated in the auditory cortex 100 -200 ms from sound change onset. Yet, single-unit recordings in animals suggest much earlier (ϳ20 -40 ms), and anatomically lower (i.e., thalamus and midbrain) deviance detection. In humans, recordings of the scalp middle-latency AEPs have confirmed early (ϳ30 -40 ms) deviance detection. However, involvement of the human auditory brainstem in deviance detection has not yet been demonstrated. Here we recorded the auditory brainstem frequency-following response (FFR) to consonant-vowel stimuli (/ba/, /wa/) in young adults, with stimuli arranged in oddball and reversed oddball blocks (deviant probability, p ϭ 0.2), allowing for the comparison of FFRs to the same physical stimuli presented in different contextual roles. Whereas no effect was observed for the /wa/ syllable, we found for the /ba/ syllable a reduction in the brainstem FFR to deviant stimuli compared with standard ones and to similar stimuli arranged in a control block, with five equiprobable, rarely occurring sounds. These findings demonstrate that the human auditory brainstem is able to encode regularities in the recent auditory past to detect novel events, and confirm the multiple anatomical and temporal scales of human deviance detection.

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Sources of frequency following responses (FFR) in man

Cited by 141 publications

References 14 publications

Multichannel recordings of the human brainstem frequency-following response: Scalp topography, source generators, and distinctions from the transient ABR

Multichannel recordings of the human brainstem frequency-following response: Scalp topography, source generators, and distinctions from the transient ABR

Auditory Brainstem Correlates of Perceptual Timing Deficits

Novelty Detection in the Human Auditory Brainstem

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