South African plants and male reproductive healthcare: Conception and contraception

Abdillahi, H.S.; Staden, J. Van

doi:10.1016/j.jep.2012.06.047

Cited by 46 publications

(20 citation statements)

References 30 publications

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“…The seed of fluted pumpkin serves as good sources of fat, oil, protein, vitamins, and minerals (Ifon, ; Okoli & Mgbeogba, ) with diverse health‐promoting properties (Caili, Huan, & Quanhong, ). They are used in traditional medicine to improve libido, enhance sexual performance, and improve fertility in men (Abdillahi & van Staden, ; Erhabor, Idu, & Udo, ; Jiofack et al, ). Diet supplemented with fluted pumpkin seed has been shown to inhibit the induction of andropause in experimental animals (Ejike & Ezeanyika, ).…”

Section: Introductionmentioning

confidence: 99%

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Fluted pumpkin ( Telfairia occidentalis ) seed modulates some markers of erectile function in isolated rat’s corpus cavernosum: Influence of polyphenol and amino acid constituents

et al. 2019

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Pumpkin seeds are often used in traditional medicine in the management of erectile dysfunction. However, there is insufficient information about the possible biochemical rationale behind this practice. Hence, this study investigated the influence of fluted pumpkin seed on critical enzymes involved in erectile function in isolated rats’ corpus cavernosum in vitro. The phenolics and amino acid contents of fluted pumpkin seed were determined using HPLC‐DAD and GC‐PFPD analyses respectively. The aqueous extract of the fluted pumpkin seed significantly (p < .05) scavenged free radicals and inhibited PDE‐5, arginase, AChE, and ACE in rats’ corpus cavernosum in a concentration‐dependent pattern. Quercitrin and luteolin were the most dominant phenolics, while arginine, aspartate, and cysteine were the most aboundant amino acid constituents. The positive modulatory effect of the fluted pumpkin seed on these critical markers of erectile function could be attributed to its polyphenolics and amino acid constituents. Practical applications This study brought to limelight the medicinal importance of fluted pumpkin seed in erectile functions. Therefore, this seed could be used as a functional food ingredient in the management of erectile dysfunctions and also in improving erectile functions in men. In addition, the dominant phenolics and amino acid constituents of this seed might be an effective nutraceutical in enhancing erections in men.

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Section: Introductionmentioning

confidence: 99%

“…They are used in traditional medicine to improve libido, enhance sexual performance, and improve fertility in men (Abdillahi & van Staden, 2012;Erhabor, Idu, & Udo, 2013;Jiofack et al, 2010). Diet supplemented with fluted pumpkin seed has been shown to inhibit the induction of andropause in experimental animals (Ejike & Ezeanyika, 2012).…”

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confidence: 99%

Fluted pumpkin ( Telfairia occidentalis ) seed modulates some markers of erectile function in isolated rat’s corpus cavernosum: Influence of polyphenol and amino acid constituents

et al. 2019

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“…These findings may well suggest that the root bark extract has greater acute toxicity than the whole root extract following oral Administration (Mongalo et al, 2015). Out of the 61 plant species, used traditionally to treat male sexual disorders, only S. longepedunculata is also traditionally used as a contraceptive (Abdillahi and Van Staden, 2012), they are also used for contraceptive purposes and abortion (Maroyi, 2013;Mustapha, 2013a;Mustapha, 2013b). These reports are pointers that this plant has toxic potentials.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 61 plants species from 36 families were found to be used traditionally to treat male sexual disorders, of the 61 plant species, only S. longepedunculata is also traditionally used as a contraceptive. The common methods of application are decoctions and/or infusions in water, beer or milk taken orally (Abdillahi and Van Staden, 2012). Erectile dysfunction (ED) is a neurovascular event and entails the inability to sustain an erection during coitus as well as a decreased libido.…”

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confidence: 99%

Effect of Securidaca longepedunculata root-bark methanol extract on testicular morphometry of New Zealand rabbits

Chika¹,

Luka²,

Azubuike³

2017

J. Vet. Med. Anim. Health

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The aim of this work was to determine the effect of the root-bark extract of Securidaca longepedunculata in the improvement of fertility in buck rabbits as envisioned by morphometric indices of the testes. Testicular morphometry of New Zealand rabbits was studied following treatment with different doses of the extract. The extract was administered per os in three doses of 0, 50 and 100 mg/kg body weight to three treatment groups of rabbits A, B, and C respectively for 29 days in a completely randomized designed (CRD). Eighteen mature buck rabbits between the ages of 18 and 24 months and with initial body weight (1.1 to 1.9 kg) were used. Each group comprised of three rabbits replicated twice. After the period of treatment, rabbits were weighed and sacrificed. Mean absolute paired testes weight, testes length and testes width were obtained and expressed relative to body weight at sacrifice. The results showed a significant difference in the mean relative paired testes weight, testes length and testes width between groups (p<0.05). The treated group given 50 mg/kg body weight of the extract had the highest mean absolute and relative paired testes weight of 3.325 ± 0.1349 a g and 0.2098 ± 0.0139 a % with mean absolute and relative testes length of 2.4522 ± 0.0250 a cm and 0.1538 ± 0.0040 a %. While the group given 100 mg/kg body weight of the extract had the lowest values of 2.634 ± 0.2762 b g and 0.1565 ± 0.0124 b % with mean absolute and relative paired testes length of 2.1600 ± 0.0807 b cm and 0.1299 ± 0.0039 b % respectively. It was concluded that administration of the extract at 50 mg/kg body weight yielded higher testicular parameters of buck rabbits. It was recommended that the use of the extract in bucks should be done with caution in relation to dose and length of treatment and that a detailed research should be carried out to evaluate the semen quality of bucks treated with 50 mg/kg the extract.

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“…et al (2011) a total of 123 plants were reported to exhibit aphrodisiac properties. In South Africa, Abdillahi and Van Staden (2012) reported about twenty five plants used for male reproductive ailments, the majority of which are used as aphrodisiacs and to treat impotency. Gelfand et al (1985) listed over fifty plants used by Zimbabwean males in treating sexual dysfunction.…”

Section: Introductionmentioning

confidence: 99%

A comparative study on the aphrodisiac activity of food plants <i>Mondia whitei, Chenopodium album,Ccucurbita pepo</i> and <i>Sclerocarya birrea</i> extracts in male wistar rats

Sewani-Rusike¹,

Iputo²,

Ndebia³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

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Background: Any substance that increases erectile function, sexual performance and enjoyment is considered an aphrodisiac. The aim of this study was to compare the effects of food plants Mondia whitei, Chenopodium album, Cucurbita pepo and Sclerocarya birrea extracts at a fixed dose of 200mg/kg body weight on sexual behavior, sperm parameters and testosterone levels in adult male rats. These are food plants also traditionally used as aphrodisiacs in South Africa, Zimbabwe and other parts of Africa. Materials and methods: Sexual behavior parameters assessed in this study included an arousal component (mount latency and intromission latency); sexual potency (mount frequency and intromission frequency), erection (copulatory efficiency) and ejaculations. All treatments were administered orally daily for 28 days. Sexual behavior parameters were quantified 2 hours after a single dose, at 14 days and at 28 days of treatment. Results: The order of efficacy in stimulating sexual behavior in male rats was M. whitei >S. birrea > C. pepo ≥ C. album. Although there was no change in number of ejaculations and sperm count (P>0.05) for all treatment groups compared to controls, all treatments increased (P<0.05) sperm motility. M. whitei and C. pepo treatments resulted in increased (P<0.05) serum testosterone levels. Conclusion: Therefore, this study demonstrates varying aphrodisiac activities of food plants used traditionally as aphrodisiacs.

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South African plants and male reproductive healthcare: Conception and contraception

Cited by 46 publications

References 30 publications

Fluted pumpkin ( Telfairia occidentalis ) seed modulates some markers of erectile function in isolated rat’s corpus cavernosum: Influence of polyphenol and amino acid constituents

Fluted pumpkin ( Telfairia occidentalis ) seed modulates some markers of erectile function in isolated rat’s corpus cavernosum: Influence of polyphenol and amino acid constituents

Effect of Securidaca longepedunculata root-bark methanol extract on testicular morphometry of New Zealand rabbits

A comparative study on the aphrodisiac activity of food plants <i>Mondia whitei, Chenopodium album,Ccucurbita pepo</i> and <i>Sclerocarya birrea</i> extracts in male wistar rats

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