Sovremennye aspekty transplantatsii ostrovkov podzheludochnoy zhelezy pri sakharnom diabete

Дедов, И И; Балаболкин, М. И.; Klebanova, Elena Michailovna

doi:10.14341/2072-0351-5607

Cited by 2 publications

(1 citation statement)

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“…It is likely that this was due to the limited techniques of islet isolation available at the time, low islet yield, and severe immunosupression. Shapiro et al [62] developed the Edmonton protocol that reduced the alloimmune response and improved the survival rate of transplanted islets [62][63][64]. Ow-ing to this protocol, the need for exogenous insulin was eliminated following islet transplantation.…”

Section: Transplantation Of Donor Islets Of Langerhansmentioning

confidence: 99%

Stem Cells in the Treatment of InsulinDependent Diabetes Mellitus

et al. 2016

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Diabetes affects over 350 million people worldwide, with the figure projected to rise to nearly 500 million over the next 20 years, according to the World Health Organization. Insulin-dependent diabetes mellitus (type 1 diabetes) is an endocrine disorder caused by an autoimmune reaction that destroys insulin-producing -cells in the pancreas, which leads to insulin deficiency. Administration of exogenous insulin remains at the moment the treatment mainstay. This approach helps to regulate blood glucose levels and significantly increases the life expectancy of patients. However, type 1 diabetes is accompanied by long-term complications associated with the systemic nature of the disease and metabolic abnormalities having a profound impact on health. Of greater impact would be a therapeutic approach which would overcome these limitations by better control of blood glucose levels and prevention of acute and chronic complications. The current efforts in the field of regenerative medicine are aimed at finding such an approach. In this review, we discuss the time-honored technique of donor islets of Langerhans transplantation. We also focus on the use of pluripotent stem and committed cells and cellular reprogramming. The molecular mechanisms of pancreatic differentiation are highlighted. Much attention is devoted to the methods of grafts delivery and to the materials used during its creation.

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Section: Transplantation Of Donor Islets Of Langerhansmentioning

confidence: 99%

Stem Cells in the Treatment of InsulinDependent Diabetes Mellitus

et al. 2016

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Immunohystochemical study of the largest islets of human pancreas in aging and diabetes mellitus: perspectives for the transplantation

et al. 2013

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Aim. To study the distribution and cellular architecture of the largest human pancreatic islets (with a diameter of more than 200 micron) in aging and diabetes mellitus types 1 and 2. Materials and methods. Antibodies to insulin, glucagon, somastatin and nturon-specific enolase were applied. The autopsy samples of the pancreatic tissue of patients with diabetes mellitus type 1 (DMT1) and type 2 (DMT2) and 2 age groups (up to 50 years old (control) and after 50 (aging control)), not suffering from diseases of the pancreas and carbohydrate metabolism malfunction were investigated. Results. The number of islets with diameter more than 200 mkm compared to control group increased both in aging and diabetes groups. Their number reaches in some cases 15% (and higher in DM) of the total number of islets. These islets compared to the other are rich-vascularized. It was shown that glucagon and somatostatin-containing cells are found both on the periphery of the large islets, and inside them only in the immediate proximity of the capillaries. Insulin-containing cells form clusters, surrounded by the capillaries and the ?- and ?-cells, while the inner part of such clusters has no direct contact with the capillaries. In the large islets the number of glucagon-containing cells is often increased, and insulin-containing cells show signs of degradation. Conclusion. The largest of the pancreatic islets may be useless for the transplantation, because of the high content of glucagon-containing cells, the rich vascularization and, in some cases, the limited functionality of ?-cells.

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Sovremennye aspekty transplantatsii ostrovkov podzheludochnoy zhelezy pri sakharnom diabete

Cited by 2 publications

References 1 publication

Stem Cells in the Treatment of InsulinDependent Diabetes Mellitus

Stem Cells in the Treatment of InsulinDependent Diabetes Mellitus

Immunohystochemical study of the largest islets of human pancreas in aging and diabetes mellitus: perspectives for the transplantation

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