SOX10 expression in mammary invasive ductal carcinomas and benign breast tissue

Chiu, Kenrry; Ionescu, Diana N.; Hayes, Malcolm

doi:10.1007/s00428-019-02557-1

Cited by 21 publications

(28 citation statements)

References 32 publications

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“…The high expression rate in BLBCs notwithstanding, SOX10 was also expressed in some 5NP and non-TNBC cases. [20][21][22][23] In the current series, SOX10 was expressed in 22.8% of 5NP cases, whereas, for the non-TNBCs, SOX10 was expressed in 1.7% of luminal A cases, 3.9% of luminal B cases, and 1.3% of HER2-OE cases. As some BLBCs do not express basal CK, 38 this may indicate that some 5NP IBCs may possess basal-like differentiation without expression of EGFR and/or CK5/6.…”

Section: Discussioncontrasting

confidence: 45%

“…The expression rate was higher than those in previous studies using whole tissue sections (63% of 43 cases, and 60% of 10 cases). 3,23 SOX10 seemed to show a consistently higher detection rate than GCDFP15 and MGB in TNBCs, 15,30 but a variably higher or lower detection rate than GATA3.…”

Section: Discussionmentioning

confidence: 84%

“…Thus, caution needs to be exercised when IHC for SOX10 in a small tumour tissue area is interpreted. However, in most of the TNBCs, IHC for SOX10 was still consistently easy to recognise, 22,23,44 as the expression is mostly diffuse and shows areas of moderate to strong intensity. For an internal control, SOX10 expression was found not only in the myoepithelial cells, but also some luminal cells of benign lobules, as previously reported.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have reported expression of Sry-related high-mobility-group/HMG box 10 (SOX10) in IBCs. [19][20][21][22][23][24] SOX10, a member of the SOX family, is essential in neural crest-derived cell survival and differentiation. 3,22,25 SOX10 is useful for identifying melanomas and nerve sheath tumours.…”

Section: Introductionmentioning

confidence: 99%

“…28 SOX10 expression was specifically found in mammary cells showing high levels of stem cell property or progenitor activity, 29 and SOX10 is preferentially expressed in TNBCs. [21][22][23][24]29 However, most of those studies included relatively small numbers of samples, and studies on the correlation of SOX10 expression with other biomarkers in TNBCs yielded conflicting results. 3,15,30 There was a tendency for SOX10 to be expressed in basallike breast cancers (BLBCs).…”

Section: Introductionmentioning

confidence: 99%

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Sry‐related high‐mobility‐group/HMG box 10 (SOX10) as a sensitive marker for triple‐negative breast cancer

Jamidi¹,

Aphivatanasiri

et al. 2020

Histopathology

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Sry-related high-mobility-group/HMG box 10 (SOX10) as a sensitive marker for triple-negative breast cancer Aims: Confirmation of a breast origin for triple-negative breast cancer (TNBC) is sometimes problematic. The traditional breast markers GATA-binding protein 3 (GATA3), mammaglobin (MGB) and gross cystic disease fluid protein 15 (GCDFP15) have shown limitations in identifying TNBC. Here, we aimed to examine the diagnostic potential of the newly proposed TNBC marker, Sry-related high-mobility-group/HMG box 10 (SOX10). Methods and results: We analysed and compared SOX10 expression with GATA3, MGB and GCDFP15 expression in a test cohort of 1838 invasive breast cancers (IBCs) by using tissue microarrays. The findings from the test cohort were further examined with a validation cohort of 42 TNBCs in whole sections. The overall expression rates of SOX10, GATA3, MGB and GCDFP15 were 6.9%, 83.1%, 47.0%, and 34.8%, respectively. Among the TNBCs within this cohort, the expression rates of SOX10, GATA3, MGB and GCDFP15 were 31.3%, 34.5%, 27.9%, and 25.2%, respectively. SOX10 was strongly associated with TNBC (P < 0.001), whereas all other traditional markers were associated with non-TNBC (P < 0.001 for all). In addition, SOX10 was more correlated to basal-like breast cancer (BLBC) (P = 0.001) than five-marker-negative subtype among the TNBCs. A high expression rate of SOX10 (81%) was confirmed in the validation cohort. Additionally, SOX10 expression was inversely correlated with GATA3 and GCDFP15 expression, so they may complement each other in TNBC detection. The SOX10-GATA3 combination yielded a sensitivity of 60.3% for TNBC detection in the test cohort. Conclusion: SOX10 is a reliable marker for identifying TNBC, and complements GATA3. The SOX10-GATA3 combination may be used as a sensitive TNBC marker.

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Section: Discussioncontrasting

confidence: 45%

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sry‐related high‐mobility‐group/HMG box 10 (SOX10) as a sensitive marker for triple‐negative breast cancer

Jamidi¹,

Aphivatanasiri

et al. 2020

Histopathology

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The Histopathology of Melanocytic Nevi and Malignant Melanoma

Willsmore¹,

Robson²

2021

Melanoma in Clinical Practice

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TRPS1 expression in cytokeratin 5 expressing triple negative breast cancers, its value as a marker of breast origin

et al. 2023

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The lack of oestrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 expression in breast cancer (BC) is the basis for the categorization of the tumour as triple negative breast carcinoma (TNBC). The majority of TNBCs are aggressive tumours with common metastases and decreased expression of markers that could help in identifying the metastatic lesion as of mammary origin. Breast markers, such as gross cystic disease fluid protein-15 (GCDPF-15), GATA binding protein 3 (GATA3), mammaglobin (MGB) and SOX10, are not uniquely specific to BC. Our aim was to evaluate trichorhinophalangeal syndrome type 1 (TRPS1) protein as a breast marker in a series of cytokeratin-5-expressing TNBC, mostly corresponding to basal-like TNBCs, previously characterized for the expression of other breast markers. One hundred seventeen TNBCs in tissue microarrays were immunostained for TRPS1. The cut-off for positivity was ≥ 10%. The reproducibility of this classification was also assessed. TRPS1 positivity was detected in 92/117 (79%) cases, and this exceeded the expression of previously tested markers like SOX10 82 (70%), GATA3 11 (9%), MGB 10 (9%) and GCDFP-15 7 (6%). Of the 25 TRPS1-negative cases, 11 were positive with SOX10, whereas 5 to 6 dual negatives displayed positivity for the other makers. The evaluation showed substantial agreement. Of the five markers compared, TRPS1 seems the most sensitive marker for the mammary origin of CK5-expressing TNBCs. Cases that are negative are most often labelled with SOX10, and the remainder may still demonstrate positivity for any of the 3 other markers. TRPS1 has a place in breast marker panels.

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SOX10 expression in mammary invasive ductal carcinomas and benign breast tissue

Cited by 21 publications

References 32 publications

Sry‐related high‐mobility‐group/HMG box 10 (SOX10) as a sensitive marker for triple‐negative breast cancer

Sry‐related high‐mobility‐group/HMG box 10 (SOX10) as a sensitive marker for triple‐negative breast cancer

The Histopathology of Melanocytic Nevi and Malignant Melanoma

TRPS1 expression in cytokeratin 5 expressing triple negative breast cancers, its value as a marker of breast origin

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