SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network

Li, Xuefei; Xu, Yingxi; Chen, Yanan; Chen, Si; Jia, Xianpei; Sun, Tongchao; Liu, Yanhua; Li, Xiru; Xiang, Rong; Li, Na

doi:10.1016/j.canlet.2013.03.027

Cited by 169 publications

(135 citation statements)

References 38 publications

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“…Wnt signaling substantially could impact NSCLC tumorigenesis, prognosis, and resistance to therapy [29]. Recently, Li et al reported that SOX2 could promote tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/b-catenin signal network [30]. Here, we found that SOX2 was overexpressed in NSCLC samples and associated with tumor size and metastasis.…”

Section: Discussionsupporting

confidence: 55%

Downregulation of miR‐638 promotes invasion and proliferation by regulating SOX2 and induces EMT in NSCLC

Xia

Liu

et al. 2014

FEBS Letters

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Edited by Tamas DalmayKeywords: miR-638 SRY (sex determining region Y)-box 2 Proliferation Invasion Epithelial-to-mesenchymal transition Non-small-cell lung cancer a b s t r a c t Aberrant expression of microRNAs has been shown to regulate the biological processes of lung cancer cells. However, the role of miR-638 in the development of NSCLC is still unclear. In this study, low miR-638 and high SOX2 were shown to be associated with tumor size and metastasis of NSCLC patients. Downregulated miR-638 could promote cell invasion and proliferation, while high miR-638 expression reversed the effect. Furthermore, miR-638 could regulate SOX2 by directly binding to its 3 0 -UTR. Silencing of SOX2 by siRNA partially abolished the enhancement of cell invasion and proliferation induced by downregulated miR-638. Aberrant miR-638 expression could modulate the expression levels of markers of epithelial-to-mesenchymal transition. Our results indicate that miR-638 may play a pivotal role in the development of NSCLC.

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Section: Discussionsupporting

confidence: 55%

Downregulation of miR‐638 promotes invasion and proliferation by regulating SOX2 and induces EMT in NSCLC

Xia

Liu

et al. 2014

FEBS Letters

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“…Additionally, the promotion effect of SOX2 on tumor cell metastasis was observed in vitro and in the tumor bearing mice in vivo. SOX2 also promoted the EMT process in the tumor cells in breast cancer by regulating the WNT/β-catenin signal pathway (94,95). A previous study on lung cancer indicated that the overexpression of SOX2 was also positively associated with the tumor-node-metastasis stage and lymph node metastasis (96).…”

Section: Association Between Sox2 and Lymph Node Metastasismentioning

confidence: 93%

Expression of SOX2 in oral squamous cell carcinoma and the association with lymph node metastasis

Ren

Zhang

2016

Oncology Letters

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Abstract. Oral squamous cell carcinomas (OSCCs) are a growing problem in the world. The various existing treatments have not markedly improved the survival rate of patients with OSCC during the past three decades. Novel treatment strategies are required. Sex determining region Y-box 2 (SOX2) is a transcription factor that is involved in the maintenance of embryonic stem cell pluripotency and in multiple developmental processes. SOX2 expression was indicated to act as a prognostic factor in various types of tumors, including breast, colorectal, gastric and lung cancer and glioblastoma, and as a link between malignancy and stemness. Cancer stem cells (CSCs) may be responsible for the genesis, growth and metastatic spread of tumors. The poor survival outcomes for OSCC patients may be attributable to a poor selection of target cells for treatment, as current oral cancer therapies are generally aimed at the global mass of tumor. Therefore, the consideration that novel approaches to oral cancer may be targeted using SOX2 and CSCs appears reasonable. In order to better understand the oncogenic roles and the corresponding signal transduction pathways of the SOX2 protein, the present study emphasizes the role of SOX2 in OSCC, including the proteins associated with OSCC, and reviews the literature regarding the role of SOX2 in lymph node metastasis. The aim of the present study is to provide a reference for future studies that engage in research on the aforementioned subject.

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“…Örneğin, özefajiyal skuamöz hücreli karsinomda AKT sinyal yolağını kullanarak büyümeyi ve hepatosellüler kanserde invazyonu uyarırken, akciğer kanserinde MAP4K4-sürvivin sinyal yolağı üzerinden hücreleri apoptoza götürmüştür (36)(37)(38). Ayrıca Sox2, WNT/β-catenin sinyal ağını düzenleyerek epitelyal-mezenşimal geçişi uyarmış ve metastaza neden olmuştur (39). Sox2'nin pozitif, Oct3/4'nin negatif ifadesinin insan gastrik kanseriyle bağlantılı olabileceği öne sürülmüştür (40).…”

Section: Sox2'nin Tümör Başlamasında Ve Gelişiminde Rolüunclassified

Kanserde yeni bir hedef haline gelen çok yönlü Sox2 geni

Turaçlı¹,

Ekmekçi²

2016

Ege Tıp Dergisi

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ÖzSox2 proteini, farklılaşmamış erken embriyo kök hücrelerinin ve çeşitli yetişkin kök hücrelerinin gelişimi ve devamlılığının düzenlenmesinde rol oynayan bir transkripsiyon faktörüdür. Sox2, diğer pluripotensi faktörleri gibi posttranskripsiyonel ve post-translasyonel değişimlere uğramakta, böylece DNA'ya bağlanma aktivitesi değişebilmektedir. Sox2, kanser hücrelerinin çoğalması, invazyon, göç ve metastazında, tümör hücre ve kök hücre statüsünün devamında, hücresel programlama, apoptoz ve kemodirenç gelişimi gibi pek çok kanser aşamasında yer almaktadır. Bazı farklı bulgulara karşın çoğunlukla Sox2'nin kanser hücrelerinde anti-apoptotik bir faktör olarak çalıştığı konusunda uzlaşma vardır. Bu derlemede, Sox2'nin kök hücre devamlılığı, farklılaşması ve sinyal iletimindeki rollerini, bunun yanında gen çoğalmasıyla onkojenik özelliği kazanmasını ve moleküler hedef olarak kullanılma potansiyelini de kapsayan çok yönlü özelliklerini kısaca tartışacağız.Anahtar Sözcükler: Sox2, kanser. Abstract Sox2 protein is a transcription factor which is important for the maintenance and regulation of the permanence of undifferentiated embryonic and adult stem cells. Like the other pluripotency factors, Sox2 can be regulated by posttranscriptional and post-translational modifications which affect its binding ability to DNA. Sox2 involves in many cellular events in the initiation and progression of tumorigenesis such as proliferation of cancer cells, invasion

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SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network

Cited by 169 publications

References 38 publications

Downregulation of miR‐638 promotes invasion and proliferation by regulating SOX2 and induces EMT in NSCLC

Downregulation of miR‐638 promotes invasion and proliferation by regulating SOX2 and induces EMT in NSCLC

Expression of SOX2 in oral squamous cell carcinoma and the association with lymph node metastasis

Kanserde yeni bir hedef haline gelen çok yönlü Sox2 geni

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