SOX21-AS1 activated by STAT6 promotes pancreatic cancer progression via up-regulation of SOX21

Yu, Dandan; Zhao, Zhentang; Wang, Li; Qiao, Shan; Yang, Zhen; Wen, Quan; Zhu, Guoqiang

doi:10.1186/s12967-022-03521-5

Cited by 12 publications

(6 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, a marked decrease in the expression of SOX21-AS1 gene was visible after Se-E2 treatment. SOX21-AS1 is highly expressed in various human cancers and may promote epithelo-mesenchymal transition and drug resistance in cancer, thus interfering with SOX21-AS1 may lead to increased sensitivity to chemotherapeutics and decreased metastasis formation [ 46 , 47 ]. Other genes that are associated with poor prognosis and tumor progression, such as ODC1 , ERN1, and ETS2 , were also downregulated primarily in the samples treated with Se-E2, Se-K2 and Se-C3 [ 48 , 49 , 50 ].…”

Section: Resultsmentioning

confidence: 99%

Reversal of Multidrug Resistance by Symmetrical Selenoesters in Colon Adenocarcinoma Cells

et al. 2023

View full text Add to dashboard Cite

Recently, selenium containing derivatives have attracted more attention in medicinal chemistry. In the present work, the anticancer activity of symmetrical selenoesters was investigated by studying the reversal of efflux pump-related and apoptosis resistance in sensitive and resistant human colon adenocarcinoma cells expressing the ABCB1 protein. The combined effect of the compounds with doxorubicin was demonstrated with a checkerboard assay. The ABCB1 inhibitory and the apoptosis-inducing effects of the derivatives were measured with flow cytometry. Whole transcriptome sequencing was carried out on Illumina platform upon the treatment of resistant cells with the most potent derivatives. One ketone and three methyl ester selenoesters showed synergistic or weak synergistic interaction with doxorubicin, respectively. Ketone selenoesters were the most potent ABCB1 inhibitors and apoptosis inducers. Nitrile selenoesters could induce moderate early and late apoptotic processes that could be explained by their ABCB1 modulating properties. The transcriptome analysis revealed that symmetrical selenoesters may influence the redox state of the cells and interfere with metastasis formation. It can be assumed that these symmetrical selenocompounds possess toxic, DNA-damaging effects due to the presence of two selenium atoms in the molecule, which may be augmented by the presence of symmetrical groups.

show abstract

Section: Resultsmentioning

confidence: 99%

Reversal of Multidrug Resistance by Symmetrical Selenoesters in Colon Adenocarcinoma Cells

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Regarding scaffold function, lncRNAs perform as a double-edged sword in regulating malignancy. LncSOX21-AS1 encourages tumor stemness and EMT by attracting USP10, thereby promoting the deubiquitination of SRY-box transcription factor 21 (SOX21) ( Yu et al, 2022 ). LncCF129 enhances the invasion and proliferation of PDAC by promoting the binding of Makorin ring finger protein 1 (MKRN1) to P53, thus leading to its ubiquitination degradation ( Liu et al, 2019 ).…”

Section: E3s and Dubs Regulated By Mi/circ/lncrnamentioning

confidence: 99%

Ubiquitin signaling in pancreatic ductal adenocarcinoma

Lv,

Zhang,

Peng

et al. 2023

Front. Mol. Biosci.

View full text Add to dashboard Cite

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignant tumor of the digestive system, characterized by rapid progression and being prone to metastasis. Few effective treatment options are available for PDAC, and its 5-year survival rate is less than 9%. Many cell biological and signaling events are involved in the development of PDAC, among which protein post-translational modifications (PTMs), such as ubiquitination, play crucial roles. Catalyzed mostly by a three-enzyme cascade, ubiquitination induces changes in protein activity mainly by altering their stability in PDAC. Due to their role in substrate recognition, E3 ubiquitin ligases (E3s) dictate the outcome of the modification. Ubiquitination can be reversed by deubiquitylases (DUBs), which, in return, modified proteins to their native form. Dysregulation of E3s or DUBs that disrupt protein homeostasis is involved in PDAC. Moreover, the ubiquitination system has been exploited to develop therapeutic strategies, such as proteolysis-targeting chimeras (PROTACs). In this review, we summarize recent progress in our understanding of the role of ubiquitination in the development of PDAC and offer perspectives in the design of new therapies against this highly challenging disease.

show abstract

“…Additionally, its role in driving cancer progression has recently attracted substantial attention. Across a spectrum of human tumors, including oral [13], lung [14][15][16], hepatocellular [17], pancreatic [18], endometrial [19], cervical [20][21][22][23][24], and breast cancers [25][26][27], as well as nephroblastoma [28], glioma [29], and osteosarcoma [30,31], SOX21-AS1 experiences aberrant regulatory patterns. Abnormal expression of SOX21-AS1 in tumor patients has been correlated with clinicopathological characteristics and survival outcomes, encompassing aspects like lymph node metastasis, tumor dimensions, clinical stage, and overall survival.…”

Section: Ivyspring International Publishermentioning

confidence: 99%

“…In glioma [29], lncRNA SOX21-AS1 acts as a sponge for miR-144-3p, resulting in the upregulation of PAK7, which induces tumor cell proliferation, migration, and invasion, while inhibiting apoptosis. In pancreatic cancer [18], lncRNA SOX21-AS1 acts as a sponge for miR-576-5p, resulting in the upregulation of SOX21, and promoting cancer progression.…”

Section: Cerna Network Involving Lncrna Sox21-as1 In Tumor Progressionmentioning

confidence: 99%

“…Downstream genes regulated by lncRNA SOX21-AS1 in tumors are shown in Figure 3. In pancreatic cancer, Yu et al [18] found that SOX21-AS1 positively regulated its nearby gene SOX21 at post-transcriptional level to promote tumor progression. LncRNA SOX21-AS1 acts as a molecular sponge, efficiently sponging SOX21 mRNA to enhance its stability and expression, and also recruits USP10, leading to deubiquitination and subsequent stabilization of SOX21 protein.…”

Section: Downstream Genes Regulated By Lncrna Sox21-as1 In Tumorsmentioning

confidence: 99%

See 1 more Smart Citation

SRY-box transcription factor 21 antisense divergent transcript 1: Regulatory roles and clinical significance in neoplastic conditions and Alzheimer's Disease

Lei,

Peng,

Luo

et al. 2023

J. Cancer

View full text Add to dashboard Cite

SRY-box transcription factor 21 antisense divergent transcript 1 (SOX21-AS1) is a multifaceted long non-coding RNA (lncRNA) that plays diverse roles in both neoplastic conditions and Alzheimer's disease. Its aberrant expression intricately regulates a wide spectrum of cellular processes, spanning from epithelial-mesenchymal transition (EMT), apoptosis, migration, metastasis, and stemness to drug resistance. SOX21-AS1 achieves these effects through its involvement in the competitive endogenous RNA (ceRNA) network, modulation of downstream genes, and regulation of critical pathways, including PI3K/AKT, Hippo, Wnt/β-catenin, and ERK signaling. Of significant clinical relevance, SOX21-AS1 expression has shown robust correlations with various clinical-pathological features. Moreover, it has demonstrated promising prognostic and diagnostic potential across a spectrum of tumors, as evidenced by existing literature and TCGA pan-cancer analyses. In Alzheimer's disease, SOX21-AS1 assumes a distinctive role. It influences neuronal viability, apoptosis, and oxidative stress by interacting with miR-107 and miR-132, and affecting the PI3K/AKT and Wnt signaling pathways. This comprehensive review sheds light on the functions of SOX21-AS1 and the regulated mechanisms underpinning its impact on neoplastic conditions and Alzheimer's disease. It underscores the clinical significance of SOX21-AS1 and positions it as a promising therapeutic target in both the oncological and neurodegenerative domains.

show abstract

SOX21-AS1 activated by STAT6 promotes pancreatic cancer progression via up-regulation of SOX21

Cited by 12 publications

References 42 publications

Reversal of Multidrug Resistance by Symmetrical Selenoesters in Colon Adenocarcinoma Cells

Reversal of Multidrug Resistance by Symmetrical Selenoesters in Colon Adenocarcinoma Cells

Ubiquitin signaling in pancreatic ductal adenocarcinoma

SRY-box transcription factor 21 antisense divergent transcript 1: Regulatory roles and clinical significance in neoplastic conditions and Alzheimer's Disease

Contact Info

Product

Resources

About