SOX9 and IL1A as the Potential Gene Biomarkers of the Oral Cancer

Li, Tianke; Cheng, Dongmei; Guo, Jie; Chen, He; Zhang, Suxin; Bao, Yang

doi:10.2174/1386207325666220628091041

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…IL10 contributes to oncogenic inactivation of tumor suppressor genes [41]. IL1A gene may be a potential therapeutic target in oral cancer, and patients with high IL1A expression have poor overall survival [42]. CCL20 increases the sensitivity of the chemotherapeutic agents lenalidomide and elotuzumab [43].…”

Section: Discussionmentioning

confidence: 99%

Single-cell RNA sequencing reveals osteosarcoma microenvironment differences between chemotherapy and without chemotherapy

Wang,

Wu,

Yao

et al. 2023

Preprint

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Background: Osteosarcoma(OS) is considered to be the most common primary bone tumor in adolescents. Currently, the main treatment for osteosarcoma is a combined neoadjuvant chemotherapy-surgery-adjuvant chemotherapy model. Unfortunately, this effective treatment regimen appears to have entered a bottleneck over the past 10 years, and the key mechanisms and mysteries triggered by osteosarcoma before and after chemotherapy have not been elucidated. This study aims to investigate the effects of osteosarcoma microenvironment between chemotherapy and without chemotherapy. Methods: We obtained data on 8 osteosarcoma cases that had undergone single-cell sequencing from a public database, including 4 cases each with and without chemotherapy. The single-cell expression profile of the degenerated nucleus pulposus was constructed by software analysis for cell filtering, data normalization, cell subcluster analysis, and cell type identification procedures, and marker genes for cell subclusters were obtained. The effects of different cell subclusters on the immune microenvironment of osteosarcoma with and without chemotherapy were further investigated by gene function analysis and pseudo time analysis. Results: The 8 osteosarcoma cases contained a total of about 100,000 single cells, and after quality control screening, a total of 80,552 cells were obtained and 8 major cell types were identified for subsequent analysis. The osteoblastic OS cells had the highest proportion of the eight major cell types, followed by the myeloid cells, osteoclasts, the proliferative OS cells, T and NK cells, endothelial cells, macrophages, and osteoblasts. Moreover, compared with the non-chemotherapy group, the heterogeneity exhibited by the chemotherapy group was also mainly reflected in several cell clusters with a high proportion. Conclusion: Revealed that oxidative phosphorylation, epithelial-mesenchymal transition, and angiogenesis are closely associated with anti-osteosarcoma deterioration, metastasis, and chemoresistance. In addition, hypoxia related genes (RGS5, CYGB, C1qtnf3) upregulated in chemotherapy have been found to be closely related to proliferation, migration, invasion and angiogenesis of osteosarcoma cells. MMP9 and MMP13 can indirectly promote tumor angiogenesis, and down-regulation of MMP9 and MMP13 may be one of the markers of prognosis in osteosarcoma patients. Downregulation of MHCI may lead to immune escape of tumor cells. Heat shock proteins (HSP) are involved in the activation and inhibition of osteosarcoma-associated pathways. These results present a deeper single-cell atlas of the tumor microenvironment for osteosarcoma and provide potential therapeutic targets for future treatment of osteosarcoma.

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Section: Discussionmentioning

confidence: 99%

Single-cell RNA sequencing reveals osteosarcoma microenvironment differences between chemotherapy and without chemotherapy

Wang,

Wu,

Yao

et al. 2023

Preprint

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“… 11 Thus, the up-regulation of IL-1α is a prognostic biomarker of cancer. 12 IL-1β is a critical mediator of chronic inflammation and is related to various cancers. Upon stimulation by IL-1β, dysfunctional oral keratinocytes (DOKs) and oral squamous cell carcinoma (OSCC) cells secrete high levels of IL-6 and IL-8.…”

Section: Role Of Inflammation-related Mediators In the Progression Of...mentioning

confidence: 99%

The Role of Inflammation-Associated Factors in Head and Neck Squamous Cell Carcinoma

Li,

Zeng,

Liu

et al. 2023

JIR

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Head and neck squamous cell carcinoma (HNSCC), which originates in the head or neck tissues, is characterized by high rates of recurrence and metastasis. Inflammation is important in HNSCC prognosis. Inflammatory cells and their secreted factors contribute to the various stages of HNSCC development through multiple mechanisms. In this review, the mechanisms through which inflammatory factors, signaling pathways, and cells contribute to the initiation and progression of HNSCC have been discussed in detail. Furthermore, the diagnostic and therapeutic potential of targeting inflammation in HNSCC has been discussed to gain new insights into improving patient prognosis.

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“…These strategies were adopted in a few studies dedicated to HNSCC. Some authors relied on them to identify network signature useful for monitoring disease progression [ 35 , 36 , 37 ], while a few others aimed to identify potential therapeutic targets [ 38 , 39 ]. In our work, we investigated a cohort of 523 tissues from subjects affected by HNSCC at different stages.…”

Section: Introductionmentioning

confidence: 99%

Differentially Expressed Genes, miRNAs and Network Models: A Strategy to Shed Light on Molecular Interactions Driving HNSCC Tumorigenesis

Arfin,

Kumar,

Lomagno

et al. 2023

Cancers

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Head and neck squamous cell carcinoma (HNSCC) is among the most common cancer worldwide, accounting for hundreds thousands deaths annually. Unfortunately, most patients are diagnosed in an advanced stage and only a percentage respond favorably to therapies. To help fill this gap, we hereby propose a retrospective in silico study to shed light on gene–miRNA interactions driving the development of HNSCC. Moreover, to identify topological biomarkers as a source for designing new drugs. To achieve this, gene and miRNA profiles from patients and controls are holistically reevaluated using protein–protein interaction (PPI) and bipartite miRNA–target networks. Cytoskeletal remodeling, extracellular matrix (ECM), immune system, proteolysis, and energy metabolism have emerged as major functional modules involved in the pathogenesis of HNSCC. Of note, the landscape of our findings depicts a concerted molecular action in activating genes promoting cell cycle and proliferation, and inactivating those suppressive. In this scenario, genes, including VEGFA, EMP1, PPL, KRAS, MET, TP53, MMPs and HOXs, and miRNAs, including mir-6728 and mir-99a, emerge as key players in the molecular interactions driving HNSCC tumorigenesis. Despite the heterogeneity characterizing these HNSCC subtypes, and the limitations of a study pointing to relationships that could be context dependent, the overlap with previously published studies is encouraging. Hence, it supports further investigation for key molecules, both those already and not correlated to HNSCC.

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SOX9 and IL1A as the Potential Gene Biomarkers of the Oral Cancer

Cited by 5 publications

References 37 publications

Single-cell RNA sequencing reveals osteosarcoma microenvironment differences between chemotherapy and without chemotherapy

Single-cell RNA sequencing reveals osteosarcoma microenvironment differences between chemotherapy and without chemotherapy

The Role of Inflammation-Associated Factors in Head and Neck Squamous Cell Carcinoma

Differentially Expressed Genes, miRNAs and Network Models: A Strategy to Shed Light on Molecular Interactions Driving HNSCC Tumorigenesis

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