Soy extracts versus hormone therapy for reduction of menopausal hot flushes

Bolaños-Díaz, Rafael; Zavala-Gonzales, Juan-Carlos; Mezones‐Holguín, Edward; Francia-Romero, José

doi:10.1097/gme.0b013e31820750bc

Cited by 15 publications

(8 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, these compounds bind to the estrogen receptors, and many studies have evaluated their effects and benefits on health and hormone replacement therapy. However, the effectiveness of the phytohormonal therapy is still uncertain (Bolaños-Díaz et al, 2011;Carmignani et al, 2010;Levis et al, 2011;Molla et al, 2011;Szkutnik-Fiedler et al, 2010).…”

Section: Introductionmentioning

confidence: 95%

Soy isoflavones have antimutagenic activity on DNA damage induced by the antileishmanial Glucantime (meglumine antimoniate)

Cantanhêde

Almeida

Soares

et al. 2014

Drug and Chemical Toxicology

View full text Add to dashboard Cite

Isoflavones are phytoestrogens reported to be potent antioxidant agents. In contrast, the antileishmanial meglumine antimoniate has mutagenic activities. This study evaluated the ability of soy isoflavones to reduce DNA damage induced by meglumine antimoniate. Antimutagenic effects (by micronucleus test) were tested using Swiss mice divided into seven groups treated with meglumine antimoniate (425 mg/kg bw pentavalent antimony); cyclophosphamide (50 mg/kg bw); water (negative control); single isoflavones dose (1.6 mg/kg bw), and three groups received one dose of isoflavones via gavage (0.4 mg/kg bw, 0.8 mg/kg bw or 1.6 mg/kg bw) plus meglumine antimoniate via intraperitoneal, simultaneously. To evaluate antigenotoxicity (by Comet assay), each group with 10 animals received the above-mentioned control doses; single dose of isoflavones 0.8 mg/kg bw, and three groups received isoflavones (0.8 mg/kg bw) by gavage along with intraperitoneal meglumine antimoniate, which were treated with isoflavones 24 h before or after receiving meglumine antimoniate (pre-treatment and post-treatment, respectively) or simultaneously. Cells were harvested 24 h after the treatment, and the data were evaluated by ANOVA followed by Tukey's test (p < 0.05). The data from the simultaneous treatment by micronucleus test revealed that isoflavones (0.4 and 0.8 mg/kg) were able to reverse the mutagenic effect of Glucantime. Moreover, all regimes of the treatment with 0.8 mg/kg bw dose were able to reduce the genotoxicity caused by meglumine antimoniate. It is suggested that the protective effect of isoflavones against DNA damage is related to their ability to reduce oxidative stress caused by the trivalent Sb(III) metabolite of meglumine antimoniate.

show abstract

Section: Introductionmentioning

confidence: 95%

Soy isoflavones have antimutagenic activity on DNA damage induced by the antileishmanial Glucantime (meglumine antimoniate)

Cantanhêde

Almeida

Soares

et al. 2014

Drug and Chemical Toxicology

View full text Add to dashboard Cite

show abstract

“…In an RCT comparing 45 mg of isoflavones twice daily, low-dose HRT (1 mg of estradiol and 0.5 mg of norethisterone acetate), and placebo using the Menopause Rating Scale, both treatments were superior to placebo, but HRT was superior to isoflavones [31]. A meta-analysis of 51 RCTs also found a statistically significant difference between the effects of HRT and soy extracts on hot flashes using indirect comparison [32].…”

Section: Effects Of Isoflavones On Menopausal Syndromes and Othersmentioning

confidence: 99%

Isoflavone Supplements for Menopausal Women: A Systematic Review

2019

View full text Add to dashboard Cite

Isoflavones have gained popularity as an alternative treatment for menopausal symptoms for people who cannot or are unwilling to take hormone replacement therapy. However, there is still no consensus on the effects of isoflavones despite over two decades of vigorous research. This systematic review aims to summarize the current literature on isoflavone supplements, focusing on the active ingredients daidzein, genistein, and S-equol, and provide a framework to guide future research. We performed a literature search in Ovid Medline using the search terms “isoflavone” and “menopause”, which yielded 95 abstracts and 68 full-text articles. We found that isoflavones reduce hot flashes even accounting for placebo effect, attenuate lumbar spine bone mineral density (BMD) loss, show beneficial effects on systolic blood pressure during early menopause, and improve glycemic control in vitro. There are currently no conclusive benefits of isoflavones on urogenital symptoms and cognition. Due to the lack of standardized research protocols including isoflavone component and dosage, outcomes, and trial duration, it is difficult to reach a conclusion at this point in time. Despite these limitations, the evidence thus far favors the use of isoflavones due to their safety profile and benefit to overall health.

show abstract

“…Soya absorpsiyonu antibiyotik kullanımı, alkol alımı ve bağırsak rahatsızlıklarından etkilenir 43 . 2011'de yapılan bir çalışmada soya kullananlarda sıcak basması plasebo grubuna göre anlamlı derecede azalmıştır 44 . Kuzey Amerika Menopoz Derneği vazomotor belirtiler için günde 50 mg Soya izoflavonu tavsiye etmektedir.…”

Section: Glycine Soja (Soya)unclassified

Menopozda Bitkisel Tedavi Kullanımı

Gün¹,

Demırcı²

2015

Arşiv Kaynak Tarama Dergisi

View full text Add to dashboard Cite

The digest has been prepared to review available clinical evidence on herbs used in treatment of menopause symptoms. Effectives of Humulus lupulus, Vitex agnus-castus, Dioskorea vilosa, Linum usitatissimum, Pinus pinaster, Turpgillere ait sebzeler, Cimicifuga racemosa L., Angelica sinensis, Oenothera biennis L., Hypericum perforatum L., Panax ginseng, Ginkgo biloba, Glycine soja, Trifolium pratense and Piper methysticum herbs were assessed for treatment of menopausal symptoms, in the studies. It was concluded that herbs used as alternative supplementary treatment for menopause symptoms have a limited effect, thus herb studies to contribute to available literature which constitute evidence are needed in order to assess effectiveness of herbal treatments for menopausal symptoms. Key words: Menopause, herbal treatment ÖZET Derleme menopoz belirtilerinin tedavisinde kullanılan bitkilere ilişkin mevcut klinik kanıtları gözden geçirmek amacıyla hazırlanmıştır. Menopozal belirtilerin tedavisi için çalışmalarda Humulus lupulus, Vitex agnus-castus, Dioskorea vilosa, Linum usitatissimum, Pinus pinaster, Turpgillere ait sebzeler, Cimicifuga racemosa L., Angelica sinensis, Oenothera biennis L., Hypericum perforatum L., Panax ginseng, Ginkgo biloba, Glycine soja, Trifolium pratense ve Piper methysticum bitkilerinin etkinlikleri değerlendirilmiştir. Sonuç olarak menopoz belirtilerinde tamamlayıcı alternatif tedavi olarak kullanılan bitkilerin sınırlı bir yere sahip olduğu, bundan dolayı menopozal belirtilerde bitkisel tedavilerin etkinliğini değerlendirmek için mevcut literatüre katkıda bulunacak kanıt düzeyi yüksek çalışmalara ihtiyaç duyulduğu söylenebilir. Anahtar kelimeler: Menopoz, bitkisel tedavi Arşiv Kaynak Tarama Dergisi . Archives Medical Review Journal 2015;24(4):520-530.

show abstract

Soy extracts versus hormone therapy for reduction of menopausal hot flushes

Cited by 15 publications

References 22 publications

Soy isoflavones have antimutagenic activity on DNA damage induced by the antileishmanial Glucantime (meglumine antimoniate)

Soy isoflavones have antimutagenic activity on DNA damage induced by the antileishmanial Glucantime (meglumine antimoniate)

Isoflavone Supplements for Menopausal Women: A Systematic Review

Menopozda Bitkisel Tedavi Kullanımı

Contact Info

Product

Resources

About