Soy Food Intake and Breast Cancer Survival

Shu, Xiao Ou; Zheng, Ying; Cai, Hui; Gu, Kai; Chen, Zhi; Zheng, Wei; Lü, Wei

doi:10.1001/jama.2009.1783

Cited by 390 publications

(337 citation statements)

References 33 publications

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“…Regarding to the associations between soy food intake after cancer diagnosis and survival (mortality or recurrence), the results were not the same based on available cohort studies (Guha et al, 2009;Shu et al, 2009;Kang et al, 2010;Caan et al, 2011;Nechuta et al, 2012;Zhang et al, 2012). One meta-analysis of four prospective cohort studies (Boyapati et al, 2005;Fink et al, 2007;Guha et al, 2009;Shu et al, 2009) showed that soy isoflavones intake was inversely associated with risk of breast cancer recurrence (Dong et al, 2011). However, two (Boyapati et al, 2005;Fink et al, 2007) of them investigated whether soy intake prior to cancer diagnosis might be associated with breast cancer survival, and the rest (Guha et al, 2009;Shu et al, 2009) evaluated whether soy intake after cancer diagnosis might be associated with breast cancer survival.…”

Section: Introductionmentioning

confidence: 96%

“…And another study conducted by Fink et al (Fink et al, 2007) reported that reduced hazard ratios [hazard ratio (95% confidence interval)] for all-cause mortality were observed among premenopausal and postmenopausal women for the highest quintile of intake prior to cancer diagnosis, compared with the lowest, for isoflavones [0.52 (0.33-0.82)]. Regarding to the associations between soy food intake after cancer diagnosis and survival (mortality or recurrence), the results were not the same based on available cohort studies (Guha et al, 2009;Shu et al, 2009;Kang et al, 2010;Caan et al, 2011;Nechuta et al, 2012;Zhang et al, 2012). One meta-analysis of four prospective cohort studies (Boyapati et al, 2005;Fink et al, 2007;Guha et al, 2009;Shu et al, 2009) showed that soy isoflavones intake was inversely associated with risk of breast cancer recurrence (Dong et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Post-diagnosis Soy Food Intake and Breast Cancer Survival: A Meta-analysis of Cohort Studies

Chi

Wu²,

Zeng³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background and Objectives: Data on associations between soy food intake after cancer diagnosis with breast cancer survival are conflicting, so we conducted this meta-analysis for more accurate evaluation. Methods: Comprehensive searches were conducted to find cohort studies of the relationship between soy food intake after cancer diagnosis and breast cancer survival. Data were analyzed with comprehensive meta-analysis software.

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Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Post-diagnosis Soy Food Intake and Breast Cancer Survival: A Meta-analysis of Cohort Studies

Chi

Wu²,

Zeng³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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show abstract

“…The role of phytoestrogens on breast cancer recurrence rates and overall survival is less well studied. Early results show inverse associations between phytoestrogen intake and breast cancer recurrence [8] and mortality [9]. Biomarkers of phytoestrogen metabolism are associated with improved survival [10].…”

Section: Introductionmentioning

confidence: 99%

The DietCompLyf study: A prospective cohort study of breast cancer survival and phytoestrogen consumption

et al. 2013

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DietCompLyf is a multi-centre prospective study designed to investigate associations between phytoestrogensnaturally occurring plant compounds with oestrogenic properties -and other diet and lifestyle factors with breast cancer recurrence and survival. 3159 women with grade I-III breast cancer were recruited 9-15 months postdiagnosis from 56 UK hospitals. Detailed information on clinico-pathological, diet, lifestyle and quality of life is collected annually up to 5 years. Biological samples have also been collected as a resource for subsequent evaluation. The characteristics of the patients and associations between pre-diagnosis intake of phytoestrogens (isoflavones and lignans; assessed using the EPIC-Norfolk UK 130 question food frequency questionnaire) and breast cancer (i) risk factors and (ii) prognostic factors are described for 1797 women who had complete data for all covariates and phytoestrogens of interest. Isoflavone intakes were higher in the patients who were younger at diagnosis, in the non-smokers, those who had breast-fed and those who took supplements. Lignan intakes were higher in patients with a higher age at diagnosis, in ex-smokers, those who had breast-fed, who took supplements, had a lower BMI at diagnosis, lower age at menarche and were nulliparous. No significant associations between pre-diagnosis phytoestrogen intake and factors associated with improved breast cancer prognosis were observed. The potential for further exploration of the relationship between phytoestrogens and breast cancer recurrence and survival, and for the establishment of evidence to improve dietary and lifestyle advice offered to patients following breast cancer diagnosis using DietCompLyf data is discussed.

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“…Contrary to these expectations, trends for a reduced risk of cancer recurrence were observed in the United States, with increasing quintiles of isoflavones intake (at levels comparable to those in Asian populations) among postmenopausal women and tamoxifen users (Guha et al, 2009). Similarly, a Chinese study reported an inverse association between soy food intake and total mortality or cancer occurrence among breast cancer survivors, with a daily isoflavone intake of 62.7 mg and more, regardless of ER status in the breast cancers or tamoxifen use (Shu et al, 2009). Even though these studies are somewhat reassuring, experts believe that the literature is still missing data on the use of isolated isoflavones and supplements as well as the longterm safety of isoflavone supplements and soy extracts in breast tissue, especially among breast cancer patients and survivors (Andres et al, 2011).…”

Section: Phytoestrogensmentioning

confidence: 91%