Soy isoflavones and immunity

Sakai, Tohru; Kogiso, Mari

doi:10.2152/jmi.55.167

Cited by 147 publications

(112 citation statements)

References 37 publications

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“…In contrast, two reports did not confirm the extensive immune abnormalities described previously and reported that a number of parameters related to immune cell populations were within the normal range in soy-fed infants [20,21]. Phytoestrogen and some of their metabolites may affect allergic responses via the enhancement of IL-4 production in T cells [22]. The functions of T cells and NK cells were altered after oral exposure to genistein at physiologically relevant concentrations in experimental animals.…”

Section: Discussionmentioning

confidence: 77%

Influence of Dietary Soy Phytoestrogens on Cytokine Production and Immunoglobulin in Ovariectomized Rats

2016

IJACEBS

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Abstract-This study was designed to examine the relationship between soy phytoestrogens supplementation in ovariectomized rats and pro-inflammatory cytokines Interleukin 1 alpha (IL-1α), Interleukin 2 (IL-2), Interleukin 4 (IL-4) and immunoglobulin. Twenty four female rats were ovariectomized then divided equally into 3 groups; control group, was fed on casein based diet, low soy phytoestrogens group was fed a diet contained 7% soy and high soy phytoestrogens group received a diet of 26% soy for 28 days. At the end of experiment, rats were weighed then blood samples were collected on EDTA for total leukocyte count (TLC). Serum samples were taken for interleukins assay, lysozyme activity and immunoglobulin. Animals were sacrificed and thymus and spleen were weighed. The body weight gain was significantly declined in ovariectomized rats fed high soy diet at the first 3 weeks of the experiment. Rats fed high soy diet showed significant reduction in thymic weight compared to control ones. IL-1α and IL-2 were significantly suppressed in rats fed high soy diet compared to control rats. However, IL-4 was significantly stimulated in rats fed high soy diet compared to control rats. Both IgM and IgG levels were significantly increased in rats fed high soy diet compared to control rats. There was a significant decrease in lysozyme activity in rats fed high soy diet compared to rats fed low soy diet. TLC was significantly increased in rats fed high and low soy diets. In conclusion, soy supplementation altered selected immunological parameters of ovariectomized female rats.

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Section: Discussionmentioning

confidence: 77%

Influence of Dietary Soy Phytoestrogens on Cytokine Production and Immunoglobulin in Ovariectomized Rats

2016

IJACEBS

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“…In support, the present data showed increased NO level in OVX rats fed SbO or SO supplemented diets. This observation may be attributed to the fact that phytoestrogens in the diet may have a role in modulating hormone related disease based on their ability to elicit estrogenic activity (Sakai and Kogiso 2008). Estrogen increases the production of NO by enhancing endothelial NO synthase activity (Sasaki et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Role of phytoestrogenic oils in alleviating osteoporosis associated with ovariectomy in rats

2012

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The objective of this study was to elucidate the effect of soybean oil (SbO) and sesame oil (SO) supplemented diets on bone biomarkers changes in OVX (ovariectomized) rats. The current data exhibited significant decrease in BMD (bone mineral density), accompanied with marked depletion in the level of Ca, P and Mg in both serum and bone of OVX rats. Also, serum estrogen, total protein, HDL-C (high density lipoprotein cholesterol), bone NO levels were decreased in OVX rats. However, a significant increase in the level of serum TL (total lipids), TC (total cholesterol), TG (triglycerides), LDL-C (low density lipoprotein cholesterol), VLDL-C (very low density lipoprotein cholesterol), urine minerals (Ca, P, Mg), as well as serum, bone and urine ALP (alkaline phosphatase) and ACP (acid phosphatase) activity were recorded in OVX rats. Further changes were also detected by the increased level of urine hydroxyproline, serum parathyroid hormone and osteocalcin, as well as urea and creatinine level in both serum and urine. On the other hand, when OVX rats were fed on SbO (soy bean oil) (15 % w/w) or SO (sesame oil) (10 % w/w) supplemented diets, the data recorded a significant improvement in all the above mentioned parameters. So, it can be concluded that consumption of SbO or SO supplemented diets might be considered as a functional food for retarding risks of osteoporosis associated with estrogen deficiency in OVX states.

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“…As one of the most important legumes species, soybean contains about 40% highly nutritious protein with all essential amino acids, rich in magnesium, phospholipids, vitamins and minerals [2][3] and also contains secondary metabolites such as isoflavones [4], saponins, phyticacid, oligosaccharides [4] and phytoestrogens [5] which are beneficial to health. In addition to its nutritional values, soybean is also used as important nitrogen (N 2 )-fixing crop throughout the world for the restoration and maintenance of soil fertility in a sustainable way and consequently the improvement of crop yields [6][7] Demand for soybean in Indonesia continues to increase, along with increasing public knowledge of the benefits of soy as a functional food.…”

Section: Introductionmentioning

confidence: 99%

Physiological characters of soybean cultivars with application of nitrogen sources under dry land conditions

Hasanah

Nisa

Hapsoh

et al. 2018

IOP Conf. Ser.: Earth Environ. Sci.

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Abstract. The objective of this study was to evaluate the influence of nutrient N management on physiological characteristics of three different soybean cultivars under dry land conditions. The study was conducted under dry lands of Desa Sambirejo (Langkat Regency) in the dry season. The study was conducted with a Randomize Block Design with two factors and three replication. The research was used a randomized block design with 2 factors and 3 replications. The first factor was soybean cultivars (Anjasmoro, Wilis, Sinabung). The second factor was N source, with Urea (50 kg/ha), Bradyrhizobium sp., farmyard manure (10 ton/ha), a combination of Bradyrhizobium sp. + farmyard manure (5 ton/ha) and a control with no N. The parameter observed in this study was the content of root N, shoot Nitrogen, shoot Phosphor, shoot Potassium and total of chlorophyll content. The results suggest that Anjasmoro and Sinabung cultivars had higher physiological characteristics (root N, shoot P and shoot K) compared to Wilis. Nitrogen source of Urea gave a higher physiological characteristics (content of root N, shoot Phosphor and shoot Potassium) compared to different treatment of N source in this study. The interaction between Anjasmoro cultivar and Urea gave the highest of content of shoot Phosphor and shoot Potassium, otherwise the interaction between Sinabung cultivar and Bradyrhizobium sp. gave the highest of content of shoot Nitrogen.

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Soy isoflavones and immunity

Cited by 147 publications

References 37 publications

Influence of Dietary Soy Phytoestrogens on Cytokine Production and Immunoglobulin in Ovariectomized Rats

Influence of Dietary Soy Phytoestrogens on Cytokine Production and Immunoglobulin in Ovariectomized Rats

Role of phytoestrogenic oils in alleviating osteoporosis associated with ovariectomy in rats

Physiological characters of soybean cultivars with application of nitrogen sources under dry land conditions

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